Results 191 to 200 of about 176,389 (357)

Advances in the Protective Effects and Mechanisms of β‐Aminoisobutyric Acid in Maintaining Multi‐Organ Homeostasis

Medicine Bulletin, EarlyView.
ABSTRACT β‐Aminoisobutyric acid (BAIBA) is an exercise‐responsive myokine/metabolite released by skeletal muscle and has attracted increasing interest as a potential exercise mimetic and therapeutic candidate in preclinical research. BAIBA acts locally in skeletal muscle and can also reach distal organs through the circulation, contributing to the ...
Hao‐Zhe Wang, Wen‐Bi He, Fei‐Peng Chen, Jiong‐Xing Huang, Lin Zhu, Xiao‐Guang Liu   +5 more
wiley   +1 more source

Perspectives of gastroenterologists on the evolving epidemiology and management of non-alcoholic fatty liver disease in Pakistan: a qualitative study. [PDF]

BMJ Open
Khan ME, Ullah M, Khan MU, Bibi A, Tariq N, Mahnoor A, Rasool M, Nasir M, Sohaib RA, Ahmed W, Ali M, Nasir M, Nawaz U, Hurairah MA.   +13 more
europepmc   +1 more source

Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice

Obesity, EarlyView.
ABSTRACT Objective High‐fat diet represses Ceacam1 transcription via a PPARα‐mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE‐RXRα in Ceacam1 promoter prevents diet‐induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.
Raziyeh Abdolahipour, Saja S. Khuder, William M. Philbrick, Agnes O. Portuphy, Getachew D. Belew, Hatem G. Fallouh, Harrison T. Muturi, Boyeon Kim, Jason K. Kim, Sonia M. Najjar   +9 more
wiley   +1 more source

Awareness of Non-alcoholic Fatty Liver Disease in Makkah, Saudi Arabia: A Cross-Sectional Study. [PDF]

Cureus
Ergesous KA, Albugami RM, Aljaafari MA, Alotaibi LA, Alshuqayfi BM, El Moursy Ali AS.   +5 more
europepmc   +1 more source

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Atherogenic index of plasma as a simple marker for NAFLD risk stratification in community-dwelling older adults: a cross-sectional study with incremental predictive value assessment. [PDF]

Front Endocrinol (Lausanne)
Xiao M, Xiao C, Zhang J, Ji Y, Zhuang J, Chen Y, Yuan Z, Chen S.   +7 more
europepmc   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Joint associations of lipoprotein(a) and systemic inflammatory indices with FibroTouch-derived hepatic steatosis and liver stiffness in Chinese adults. [PDF]

Front Immunol
Huang D, Sun Z, Shen X, Yu T, Liu S, Zhang Y, Li W, Zhang W, Wang R.   +8 more
europepmc   +1 more source

Cordycepin Alleviates Non Alcoholic Fatty Liver Disease Progression by Stabilizing GCH1 to Inhibit Ferroptosis

Phytotherapy Research, EarlyView.
COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han, Jian Sheng, Hongyan Pei, Wenyan Li, Shasha Wu, Yi Yang, Chenxi Cao, Zhiling Tang   +7 more
wiley   +1 more source

Liver Stiffness Measurement is Useful in Predicting Type 2 Diabetes Mellitus Among Nonalcohol Fatty Liver Disease Patients

Diabetes, Metabolic Syndrome and Obesity
Yuping Ding,1,2 Guiqiang Wang,3,4 Quanjun Deng,1,2 Mei Yang,1,2 Jinghua Li,5 Zuoyu Wang,1,2 Haiyan Niu,1,2 Shihai Xia1,2 1Department of Gastroenterology and Hepatology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin ...
Ding Y, Wang G, Deng Q, Yang M, Li J, Wang Z, Niu H, Xia S   +7 more
doaj