Results 31 to 40 of about 32,498 (288)

Two Competing Approaches in the Mu‘tazilite View of the Human Being: The Traditions of Abū al-Hudhayl and al-Naẓẓām [PDF]

open access: yesNazariyat: Journal for the History of Islamic Philosophy and Sciences, 2018
The aim of this article is to illustrate the two human conceptions introduced in the Basran School of Muʿtazila with their reflections on the fields like theoretical physics, epistemology, and ethics.
Yunus Cengiz
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Perspectives on Drug Addiction in Islamic History and Theology

open access: yesReligions, 2014
How does Islam view substance addiction? What happens to the soul of the person suffering from addictive disorder? What happens to his relationship with God? These are some of the questions that this article tries to answer.
Mansur Ali
doaj   +1 more source

On Their Own Ground: Strategies of Resistance for Sunni Muslim Women [PDF]

open access: yes, 2007
Drawing from work in feminist moral philosophy, Tobin argues that the most common methodology used in practical ethics is a questionable methodology for addressing practical problems across diverse cultural contexts because the kind of impartiality it ...
Tobin, Theresa
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

TAZKIYAT AL-NAFS: KAJIAN TENTANG TAZKIYAT AL-NAFS SEBAGAI PENDEKATAN DIRI KEPADA ALLAH

open access: yesJurnal Yaqzhan: Analisis Filsafat, Agama dan Kemanusiaan, 2017
iwa yang dalam bahasa Arab dikenal dengan istilah nafs. Nafs merupakan bagian yang sangat penting dalam diri manusia. Apabila nafs manusia bersih maka ia bisa dekat dengan tuhannya.
Ahmad Asmuni
doaj  

Nefis Nazariyesi Çerçevesinde Fahreddin er-Râzî’nin Ahlâk Düşüncesi

open access: yesCumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2014
Kelâm, felsefe, tefsir ve usûl-i fıkıh alanlarındaki çalışmalarıyla tanınan Eş’arî âlimi Fahreddin er-Râzî, eserlerinde genellikle akıl ve vahiy arasındaki uyum ve irtibata işaret etmektedir.
Asiye Aykıt
doaj   +1 more source

The Term “Nafs” in The Qur’ān

open access: yesKader, 2023
The definition, nature, characteristics, and identification of the nafs are among the most fundamental problems in both metaphysics and theology. The manner in which the subject of the nafs is addressed even provides the opportunity to scrutinize the ...
Tuğba Günal
doaj   +1 more source

Partial Dissociation and Hydration Quantitatively Explain the Properties of Aqueous Electrolyte Solutions and hence Empirical Activity Concepts are Unnecessary [PDF]

open access: yes, 2011
The author shows that Arrhenius's theory of partial electrolytic dissociation was immaturely displaced about eight decades ago by the empirical concept of ionic activities and the assumption of complete dissociation of electrolytes at all ...
Raji Heyrovska
core   +1 more source

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