Results 41 to 50 of about 32,498 (288)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

PEMIKIRAN PARA FILOSOF MUSLIM TENTANG JIWA

An-Nida', 2014
Tulisan ini memaparkan pemikiran beberapa filosof muslim tentang jiwa. Banyak pemikiran dalam memahami keesaan Allah yang diangkat oleh berbagai aliran dalam Islam, tetapi setelah dicermati maka semuanya mengerucut pada dua kelompok saja, yaitu pemikiran
Afrizal M
doaj   +1 more source

Konsep Tazkiyatun Nafs Menurut Sa‘Id Hawwa (1935 -1989 M) [PDF]

, 2012
Tazkiyatun nafs baik konsep maupun seputar permasalahan yang terkait dengannya selalu hangat dibicarakan oleh banyak ulama maupun pemikir sesuai dengan masa, konteks dan komunitas dari masing-masing mereka.
Manik, Junaidi
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Active tectonics of Gülpınar-Tuzla area (Biga Peninsula, NW Turkey): the source of 6 February-24 March 2017 earthquake cluster

Bulletin of the Mineral Research and Exploration, 2021
The variation in the motion sense of Anatolian platelet in Aegean Sea resulted in a strike-slip tectonic regime and related neotectonic domain, the central to northern Aegean neotectonic province, which also includes both western Marmara Sea and ...
Şule Gürboğa, Ali Koçyiğit
doaj   +1 more source

Soulmates in The Quran and Prophetic Tradition [PDF]

, 2017
Just like letters that go together in a word, there are soulmates who came in the symbolic “Be.” Spiritual partnership found in soulmates are far from foreign to Islam: to the contrary The Quran and Prophetic Tradition are replete with them. The need for
Miller, Maryam
core  

Understanding and Optimizing Li Substitution in P2‐Type Sodium Layered Oxides for Sodium‐Ion Batteries

Advanced Functional Materials, EarlyView.
This work explores Li‐substituted P2 layered oxides for Na‐ion batteries by crystallographic and electrochemical studies. The effect of lithium on superstructure orderings, on phase transitions during synthesis and electrochemical cycling and on the interplay of O‐ versus TM‐redox is revealed via various advanced techniques, including semi‐simultaneous 
Mingfeng Xu, Giovanni Gammaitoni, Michael Häfner, Eduardo Villalobos‐Portillo, Carlo Marini, Matteo Bianchini   +5 more
wiley   +1 more source

HALVETİYYE GELENEĞİNDE ETVÂR-I SEBA/NEFSİN MERTEBELERİ

Türk Kültürü ve Hacı Bektaş Velî Araştırma Dergisi, 2018
The nafs and its intentional reclamation in mystical thought is a matter of considerable importance. Almost every religious sect’s student aims to discipline his nafs. Therefore, the sects are divided as sensual and spiritual sects.
İsa Çelik, Birol Yıldırım
doaj  

PRINSIP-PRINSIP TAZKIYAH AL-NAFS DALAM ISLAM DAN HUBUNGANNYA DENGAN KESEHATAN MENTAL

An-Nida', 2012
Tazkiyah al-nafs according to language meaning means Soul cleanliness, self cleanlines. Tazkiyah al-nafs is one of methodes in soul develoving and human akhlak education.
Masyhuri Masyhuri
doaj   +1 more source