Results 141 to 150 of about 835,919 (230)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

A dual‐responsive fluorescent probe for imaging viscosity and polarity in nonalcoholic fatty liver disease

Smart Molecules, EarlyView.
We developed a BODIPY‐based fluorescent probe with dual responsiveness to viscosity and polarity, enabling sensitive and precise imaging of non‐alcoholic fatty liver disease. Abstract Viscosity and polarity are critical physiological parameters implicated in the onset and progression of nonalcoholic fatty liver disease (NAFLD).
Di Zhao, Zhizhong Wang, Ke Xu, Yuntai Liu, Di Wu, Ting Jiang, Haonan Gao, Chengmei Xiao, Debin Zheng, Kai Wang, Wenhao Zhai   +10 more
wiley   +1 more source

Carcinogenesis resistance in the longest-lived rodent, the naked mole-rat. [PDF]

Cancer Sci, 2022
Yamamura Y, Kawamura Y, Oka K, Miura K.
europepmc   +1 more source

Nature's Ambiguous Sex: The Body as a Feminist Resource in German Naturism Around 1900

Gender &History, EarlyView.
ABSTRACT While gender relations around 1900 were generally marked by sharp dichotomies grounded in nature and the body, the case of naturism appears paradoxical. An influential movement in Germany, it promoted a reform of the body according to natural principles.
Johannes Bosch
wiley   +1 more source

Genome assembly and annotation of the naked mole rat Heterocephalus glaber reared in Japan. [PDF]

Sci Data
Toga K, Oka K, Tanaka H, Itoh T, Toyoda A, Bono H, Miura K.   +6 more
europepmc   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

The Everlasting Ovary: Decoding the Mechanisms of Lifelong Oogenesis in the Naked Mole-Rat. [PDF]

Results Probl Cell Differ
Barreñada O, Pearson AC, Brieño-Enríquez MA.   +2 more
europepmc   +1 more source

Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization. [PDF]

Front Immunol, 2023
Gorshkova EA, Gubernatorova EO, Dvorianinova EM, Yurakova TR, Marey MV, Averina OA, Holtze S, Hildebrandt TB, Dmitriev AA, Drutskaya MS, Vyssokikh MY, Nedospasov SA.   +11 more
europepmc   +1 more source

Inhibin βB Mediates Oligotrophic Adaptation via Regulating Muscle Satellite Cell Proliferation and Differentiation in Schizopygopsis younghusbandi

Integrative Zoology, EarlyView.
① Nutrient deficiency upregulates inhibin βB, activating SMAD signaling to promote p21. Increased p21 inhibits mcm2/mcm4/mcm5 and cyclin E2, inducing G1‐phase arrest, slowing growth, and reducing energy consumption. ② Inhibin βB also upregulates pdgf‐c, which induces α‐SMA, leading to muscle satellite cell fibrosis.
Weiqiang Li, He Gao, Chaowei Zhou, Luo Lei, Junting Li, Chao Ma, Zitu Ma, Mengwei Yao, Kexin Ma, Yunpeng Xiang, Yan Zhou, Yongrui Lu, Da Ji, Minghong Wei, Luohao Xu, Zhaofang Han, Haiping Liu   +16 more
wiley   +1 more source

Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold. [PDF]

Proc Natl Acad Sci U S A
Mikhalchenko A, Corrigan JK, He Y, Peterfi Z, Yim SH, Lee SG, Deng Z, Amoroso VG, Gorbunova V, Seluanov A, Park TJ, Banks AS, Gladyshev VN.   +12 more
europepmc   +1 more source