Results 1 to 10 of about 2,358 (202)
Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor [PDF]
Frontiers in Psychiatry, 2022 Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate ...
Mark A. Smith +16 more
doaj +2 more sources
Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors [PDF]
BMC Neuroscience, 2002 BACKGROUND: The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic kidney cells expressing only δ opioid receptors.
Clark, J David +3 more
core +4 more sources
Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest [PDF]
ChemistryOpen, Volume 8, Issue 7, Page 879-887, July 2019., 2019 Who is in charge? In solutions, naloxone exists in four differently charged forms. Its overall lipophilicity profile indicated by the broad black line is the sum of the contributions of its four forms. Although the non‐charged form of naloxone is less lipophilic than naltrexone, its relative concentration at physiological pH is higher.
Károly Mazák +2 more
wiley +2 more sources
Pharmacological profiles of opioid ligands at kappa opioid receptors [PDF]
BMC Pharmacology, 2006 BACKGROUND: The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse κ-opioid receptors.
Pamela J Shaw
exaly +3 more sources
Activity of opioid ligands in cells expressing cloned mu opioid receptors [PDF]
BMC Pharmacology, 2003 BACKGROUND: The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a cell system expressing only mu opioid receptors.
David Clark, J +3 more
exaly +3 more sources
Opioid-Induced Immunomodulation: Consequences for the Experimental Coxsackievirus B3-Induced Myocarditis Model [PDF]
Biology (Basel), 2020 Myocarditis is an inflammatory disorder of the heart predominantly caused by infectious agents. Since more than sixty years, the Coxsackievirus B3 (CVB3)-induced myocarditis mouse model is the experimental model used to investigate viral myocarditis. The
Linthout, Sophie Van, Pappritz, Kathleen
core +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Drug Testing and Analysis, Volume 15, Issue 9, Page 980-986, September 2023., 2023 Hair testing provides valuable and objective information on in utero drug exposure. To obtain a complete picture of the mother's addiction behaviour and of her family background, it is advisable to collect on the day of birth or the day after birth not only hair from the mother, newborn and father but also urine from the mother and newborn. Cocaine and
Anna Bertaso +8 more
wiley +1 more source
The Oxford Catalogue of Opioids: A systematic synthesis of opioid drug names and their pharmacology
British Journal of Clinical Pharmacology, Volume 87, Issue 10, Page 3790-3812, October 2021., 2021 Aim The growing demand for analgesia, coupled with an increasing need to treat opioid dependence and overdose, has escalated the development of novel opioids. We aimed to quantify the number of opioid drugs developed and to catalogue them based on their pharmacology.
Georgia C. Richards +3 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source