BMC Research Notes, 2012 Background Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in ...
Heinälä Pekka +5 more
doaj +1 more source
Unexpected Variation of the Codeine/Morphine Ratio Following Fatal Heroin Overdose [PDF]
, 2014 Postmortem samples from 14 cases of suspected heroin overdose were subjected to a preliminary systematic toxicological analysis in order to highlight the presence of unknown exogenous compounds (e.g., drugs of abuse, alcohol) that may have played a ...
Cippitelli M, Gambaro V, Guerrini K
core +1 more source
Comparison of chemical clustering methods using graph- and fingerprint-based similarity measures [PDF]
, 2003 This paper compares several published methods for clustering chemical structures, using both graph- and fingerprint-based similarity measures. The clusterings from each method were compared to determine the degree of cluster overlap. Each method was also
Blankley, C.J. +2 more
core +1 more source
TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]
, 2019 Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G. +9 more
core +3 more sources
Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]
, 2012 Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas +7 more
core +2 more sources
MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys [PDF]
, 2012 MDAN-21, , a bivalent opioid ligand containing a mu-opioid receptor agonist (derived from oxymorphone) linked to the delta-opioid receptor antagonist (related to naltrindole) by a spacer of 21 atoms, was reported to have potent analgesic properties in ...
Aceto, Mario D. +6 more
core +4 more sources
Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue [PDF]
, 1992 In an experimental model of unilateral pneumonia caused by Klebsiella pneumoniea in rats we investigated whether intravenous administration of liposomes with prolonged blood circulation time resulted in significant localization of liosomes in infected ...
Bakker-Woudenberg, I.A.J.M. (Irma) +3 more
core +1 more source
Effects of Cyclamen trochopteranthum on hepatic drug-metabolizing enzymes [PDF]
, 2011 The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A ...
Arslan Sevki +6 more
core +1 more source
Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in rats. [PDF]
, 2001 Animal and clinical data show that high ratios of the area under the concentration-time curve and the peak concentration in blood to the MIC of fluoroquinolones for a given pathogen are associated with a favorable outcome ...
Allen T. M. +23 more
core +4 more sources
Isolation of Nalorphine Ethereal Sulfate and Nalorphine Glucuronide from Urine of Cat and Rabbit
Experimental Biology and Medicine, 1969 SummaryIsolation of a major metabolite of nalorphine from the urine of the cat was accomplished. This metabolite was nalorphine-3-ethereal sulfate by chemical synthesis of the compound. Evidence is presented to characterize the crystalline metabolite isolated from the urine of the rabbit as nalorphine-3-glucuronide.
J M, Fujimoto +2 more
openaire +2 more sources