Targeting RNA Polymerase I in Ewing Sarcoma Treatment
Cancer Science, EarlyView.Pharmacologic inhibition of RNA polymerase I activity represents a new therapeutic approach for Ewing sarcoma. This is the first time key components of the ribosome biogenesis pathway have been linked to Ewing sarcoma biology.
Alexis Bruce +7 more
wiley +1 more source
Choosing an analytic approach: Key study design considerations in state policy evaluation [PDF]
arXivThis paper reviews and details methods for state policy evaluation to guide selection of a research approach based on evaluation setting and available data. We highlight key design considerations for an analysis, including treatment and control group selection, timing of policy adoption, expected effect heterogeneity, and data considerations.
arxiv
Primary afferent depolarisation of tooth pulp afferents is not affected by naloxone [PDF]
, 1978 James W. Hu +2 more
openalex +1 more source
Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications
Cell Proliferation, EarlyView.ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Jiajia Li +7 more
wiley +1 more source
Readiness and recovery : switching between methadone and buprenorphine/naloxone for the treatment of opioid use disorder : a 90 credit thesis submitted in partial fulfillment of the requirements for the degree of Master of Nursing at Massey University, Wellington, New Zealand [PDF]
, 2016 Opioid substitution treatment is an effective form of treatment for opioid use disorders. Long acting opiates are used as part of treatment with methadone and buprenorphine/naloxone (BUP/NX) most frequently prescribed.
Bishop, Blair Thomas
core
Naloxone-induced aversion to sucrose in morphine-dependent rats [PDF]
, 1975 Joseph W. Ternes
openalex +1 more source
Drug and Alcohol Review, EarlyView.Abstract Introduction Various novel harm reduction services leverage technology to reduce the rising number of drug poisoning deaths, particularly among those who use drugs alone. There is significant variability in terminology and outcome measures in reporting these interventions, complicating efforts to build a comprehensive knowledge base.
William Rioux +16 more
wiley +1 more source
Considering the Potential Benefits of Over-the-Counter Naloxone
Integrated Pharmacy Research and Practice, 2021 Kirk E Evoy,1 Lucas G Hill,2 Corey S Davis3 1University Health, Department of Pharmacy, The University of Texas at Austin College of Pharmacy, San Antonio, TX, USA; 2Pharmacy Practice, The University of Texas at Austin College of Pharmacy, Austin, TX ...
Evoy KE, Hill LG, Davis CS
doaj
Canadian Medical Association Journal, 2018 Tina, Hu, Larry, Nijmeh, Adam, Pyle
openaire +2 more sources
Trends in novel opioid use and detections in exposures and police drug seizures in New South Wales
Drug and Alcohol Review, EarlyView.Abstract Introduction Novel opioids, including non‐medical and non‐opium‐based opioids such as fentanyl analogues and nitazenes, pose a significant risk of harm due to their high potency. There is little published data on novel opioid detections and harms in Australia, yet they are implicated in multiple deaths.
Janette L. Smith +7 more
wiley +1 more source