Results 21 to 30 of about 25,222 (249)

Factors associated with the percentage of individuals who initiate and discontinue naltrexone as a relapse prevention pharmacotherapy in opioid use disorder: A systematic review, meta-analysis and meta-regression. [PDF]

Addiction
Abstract Background and aims Naltrexone is a pharmacotherapeutic option for relapse prevention in opioid use disorder (OUD); however, studies highlight low rates of initiation and high rates of discontinuation as limiting its effectiveness. We aimed to (1) estimate the percentage of individuals with OUD who (having undergone withdrawal and wish to ...
Roberts E, Sanderson E, Santo T, Hickman M, Farrell M, Degenhardt L.   +5 more
europepmc   +2 more sources

Naltrexone, Naloxone, Morphine, and Fentanyl Pharmacologically Chaperone a Mutant μ-Opioid Receptor via an Endoplasmic Reticulum Exit Site-Dependent Pathway. [PDF]

Pharmacol Res Perspect
ABSTRACT Opioid receptor antagonists increase the plasma membrane density of μ‐opioid receptors (MOR) in vivo, thereby inducing “supersensitivity” to opioid agonists. This phenomenon increases the risk of overdose in patients that were being treated with naltrexone (Ntx), a popular MOR antagonist.
Grant SN, Mulcahy MJ, Lester HA.
europepmc   +2 more sources

The effects of Naltrexone among alcohol non-abstainers: results from the COMBINE Study

Frontiers in Psychiatry, 2010
These analyses of the COMBINE Study examined the effects of naltrexone among non-abstainers. Given that one of the most well-established mechanisms of action of naltrexone involves blunting of alcohol reward, it is hypothesized that naltrexone should be ...
Lara Ray, Jennifer L Krull, Lorenzo Leggio   +2 more
doaj   +1 more source

Naltrexone in the treatment of pruritus

, 2006
Naltrexone is a cyclopropyl derivative of oxymorphone which behaves as a competitive antagonist of opioid receptors. Naltrexone is usually used in weaning opioid-dependent patients.
S. Veraldi, F. Celotti, R. Caputo
core   +5 more sources

Exploring genetic predictors of naltrexone treatment response in opioid use disorder

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
Purpose: The present study was aimed to evaluate the effect of the opioid receptors genes and dopamine system genes polymorphisms on the treatment outcomes of opioid dependence with implantable and oral naltrexone in randomized double blinded double ...
Е. A. Blokhina ., E. М. Krupitsky, А. O. Kibitov, V. Ya. Palatkin, T. S. Yaroslavtseva, Е. V. Verbitskaya, E. E. Zvartau   +6 more
doaj   +1 more source

Open Label Trial of Naltrexone Implants: Measuring Blood Serum Levels of Naltrexone

, 2013
The usefulness of oral naltrexone has been limited by compliance. Sub-cutaneous implants would seem to offer a solution to this problem and improve long-term outcomes.
Ross M. Colquhoun
core   +1 more source

Low-dose naltrexone-induced remission in Hailey–Hailey disease maintained in remission with topical combination of ketamine and diphenhydramine

Indian Dermatology Online Journal, 2019
Recent anecdotal evidence suggests that oral low-dose naltrexone (LDN) is effective for Hailey–Hailey disease (HHD) but suffers the limitation of immediate relapse following cessation of the medication.
Sidharth Sonthalia, Mahima Agrawal, Ankur Talwar, Mohamad Goldust   +3 more
doaj   +1 more source

A Case Report of a Dual Diagnosis Patient: Naltrexone for the Treatment of Severe Nitrous Oxide Use Disorder with Associated Neurological and Psychiatric Sequelae

Journal of Scientific Innovation in Medicine, 2023
Background: Nitrous oxide (N2O) is a non-regulated substance with increasing prevalence as a drug of abuse. N2O abuse is associated with both neurological and psychiatric sequelae, including psychotic symptoms.
Paige Juliet Staudenmaier, Veronica Kane, Amulya Iyer, Paul Campion   +3 more
doaj   +1 more source

Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors

Frontiers in Immunology, 2017
The opioid antagonist naltrexone hydrochloride has been suggested to be a potential therapy at low dosage for multiple inflammatory conditions and cancers.
Rachel Cant, Angus G. Dalgleish, Rachel L. Allen   +2 more
doaj   +1 more source

Naltrexone Treatment for Methamphetamine Dependence – Service Evaluation Audit

BJPsych Open
Aims There is an emerging evidence base to support the benefit of naltrexone prescription in methamphetamine dependence. This audit assesses prescribing practice and benefit of naltrexone in a specialist NHS drug service based in West London.
Emma Stimson, Owen Bowden-Jones
doaj   +1 more source