Results 141 to 150 of about 59,458 (179)
Die Pharmazie, 2010 Recent reports have demonstrated that topical and systemic application of naltrexone markedly improves the characteristic signs of diabetic keratopathy; most notably, impaired corneal sensation and delayed wound repair. The aim of this study was to prepare and characterise non-ionic surfactant vesicles (niosomes) for the ocular drug delivery of ...
H, Abdelkader +3 more
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Journal of Pharmaceutical Sciences, 2011
This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and stearyl amine (STA)] and surfactants [poly-24-oxyethylene cholesteryl ether (C24) and sodium cholate (CH)] were investigated as bilayer membrane additives and prepared using four
Hamdy Abdelkader +2 more
exaly +3 more sources
This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and stearyl amine (STA)] and surfactants [poly-24-oxyethylene cholesteryl ether (C24) and sodium cholate (CH)] were investigated as bilayer membrane additives and prepared using four
Hamdy Abdelkader +2 more
exaly +3 more sources
Advances in Therapy, 2010
Morphine sulfate and naltrexone hydrochloride extended release capsules, indicated for chronic moderate-to-severe pain, contain extended-release morphine pellets with a sequestered naltrexone core. If pellets are tampered by crushing, naltrexone is released to reduce morphine-induced effects that appeal to opioid abusers.
Dennis Swearingen, Joseph Stauffer
exaly +3 more sources
Morphine sulfate and naltrexone hydrochloride extended release capsules, indicated for chronic moderate-to-severe pain, contain extended-release morphine pellets with a sequestered naltrexone core. If pellets are tampered by crushing, naltrexone is released to reduce morphine-induced effects that appeal to opioid abusers.
Dennis Swearingen, Joseph Stauffer
exaly +3 more sources
International Journal of Pharmaceutics, 1999
The percolation theory is a statistical theory able to study chaotic or disordered systems that has been applied in the pharmaceutical field since 1987. Through the application of this theory, the design of controlled release inert matrices has been improved.
Josefa Alvarez-Fuentes +2 more
exaly +3 more sources
The percolation theory is a statistical theory able to study chaotic or disordered systems that has been applied in the pharmaceutical field since 1987. Through the application of this theory, the design of controlled release inert matrices has been improved.
Josefa Alvarez-Fuentes +2 more
exaly +3 more sources
Pharmaceutical Research, 2010
Transdermal delivery of drugs is often limited by formidable barrier properties of stratum corneum (SC). Microneedles (MN) enable creation of transient microchannels in the SC and bypass this barrier. Many reports have focused on the great effectiveness of MN in improving percutaneous flux values of a variety of drugs over a large molecular size ...
Audra Stinchcomb, Mikolaj Milewski
exaly +3 more sources
Transdermal delivery of drugs is often limited by formidable barrier properties of stratum corneum (SC). Microneedles (MN) enable creation of transient microchannels in the SC and bypass this barrier. Many reports have focused on the great effectiveness of MN in improving percutaneous flux values of a variety of drugs over a large molecular size ...
Audra Stinchcomb, Mikolaj Milewski
exaly +3 more sources
Journal of Pharmaceutical Sciences, 2007 The crystal structures of the analgesic compounds anhydrous naloxone and naltrexone hydrochloride were determined ab initio from high resolution laboratory X-ray powder diffraction data. Both compounds crystallize in the orthorhombic space group P2(1)2(1)
Kunihisa Sugimoto, Robert Dinnebier
exaly +1 more source
Clonidine Hydrochloride Detoxification from Methadone Treatment-
Advances in Alcohol & Substance Abuse, 1984Treatment outcomes were compared for 2 groups of subjects detoxified from methadone using clonidine. One group of 12 subjects was encouraged to continue in treatment with naltrexone, while the other 12 subjects did not have naltrexone treatment available.
R A, Rawson +3 more
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Genetic Screening of Compounds Used in Drug Abuse Treatment I. Naltrexone Hydrochloride
Drug and Chemical Toxicology, 1978Several compounds used clinically in drug abuse therapy were evaluated for genetic activity in a series of in vitro assays. This initial report describes the results for one of these compounds, Naltrexone. Nalrexone is a relatively nontoxic drug antagonist related to Naloxone which appears to be effective in diminishing the euphoria and dependence upon
D, Brusick +4 more
openaire +2 more sources
The Journal of Clinical Pharmacology, 2012
Although contraindicated, coingestion of alcohol and opioids by patients or drug abusers is a major health concern because of dangerous additive and potentially life‐threatening sedative and respiratory effects. In addition, alcohol has been shown to disrupt the extended‐release characteristics of certain extended‐release opioid formulations, releasing
Franklin K, Johnson +4 more
openaire +2 more sources
Although contraindicated, coingestion of alcohol and opioids by patients or drug abusers is a major health concern because of dangerous additive and potentially life‐threatening sedative and respiratory effects. In addition, alcohol has been shown to disrupt the extended‐release characteristics of certain extended‐release opioid formulations, releasing
Franklin K, Johnson +4 more
openaire +2 more sources
[Pharmacokinetics of naltrexone hydrochloride and naltrexone glucuronide in the dog].
Yao xue xue bao = Acta pharmaceutica Sinica, 1997Pharmacokinetics of naltrexone hydrochloride (NTX) and naltrexone glucuronide was studied in the dog using HPLC-electrochemical detection with naloxone as internal standard. After iv 5 mg or po 10 mg NTX, the plasma concentration-time curves of NTX were found to fit to a two-compartment model and a single compartment with first-order absorption.
H, Li, S F, Zhao, N, Wang, Z H, Ge
openaire +1 more source