Results 161 to 170 of about 4,819 (199)
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[Pharmacokinetics of naltrexone hydrochloride and naltrexone glucuronide in the dog].
Yao xue xue bao = Acta pharmaceutica Sinica, 1997Pharmacokinetics of naltrexone hydrochloride (NTX) and naltrexone glucuronide was studied in the dog using HPLC-electrochemical detection with naloxone as internal standard. After iv 5 mg or po 10 mg NTX, the plasma concentration-time curves of NTX were found to fit to a two-compartment model and a single compartment with first-order absorption.
H, Li, S F, Zhao, N, Wang, Z H, Ge
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The Journal of Clinical Pharmacology, 2012
Although contraindicated, coingestion of alcohol and opioids by patients or drug abusers is a major health concern because of dangerous additive and potentially life‐threatening sedative and respiratory effects. In addition, alcohol has been shown to disrupt the extended‐release characteristics of certain extended‐release opioid formulations, releasing
Franklin K, Johnson +4 more
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Although contraindicated, coingestion of alcohol and opioids by patients or drug abusers is a major health concern because of dangerous additive and potentially life‐threatening sedative and respiratory effects. In addition, alcohol has been shown to disrupt the extended‐release characteristics of certain extended‐release opioid formulations, releasing
Franklin K, Johnson +4 more
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Current Medical Research and Opinion, 2018
To review the effects of naltrexone on withdrawal-related adverse events (AEs) and euphoria-related effects, and the relationship between plasma naltrexone concentrations and withdrawal across EMBEDA (MSN; extended-release morphine sulfate with sequestered naltrexone) studies.Five studies in pain patients and a safety review summarizing AE reports ...
Beatrice, Setnik +3 more
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To review the effects of naltrexone on withdrawal-related adverse events (AEs) and euphoria-related effects, and the relationship between plasma naltrexone concentrations and withdrawal across EMBEDA (MSN; extended-release morphine sulfate with sequestered naltrexone) studies.Five studies in pain patients and a safety review summarizing AE reports ...
Beatrice, Setnik +3 more
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Physicochemical Stability of Compounded Naltrexone Hydrochloride Solutions in PCCA Base SuspendIt.
International journal of pharmaceutical compounding, 2019Naltrexone hydrochloride is an orally active narcotic antagonist used to facilitate rapid transition from methadone maintenance. The dosing schedule of naltrexone hydrochloride in detoxification protocols needs to be flexible to permit precise, customized dose titration for individual patients.
Yashoda V, Pramar +5 more
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Journal of Drug Delivery Science and Technology, 2011
In the last twenty years mesoporous materials (e.g., silica, silicon, and to a lesser extent titanium) have been extensively investigated as possible carriers for controlled drug delivery purposes. The great benefits of these materials are their high surface areas and pore volumes with tunable pore sizes and easily functionalized pore surface ...
H. Abdelkader +4 more
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In the last twenty years mesoporous materials (e.g., silica, silicon, and to a lesser extent titanium) have been extensively investigated as possible carriers for controlled drug delivery purposes. The great benefits of these materials are their high surface areas and pore volumes with tunable pore sizes and easily functionalized pore surface ...
H. Abdelkader +4 more
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Journal of Clinical Psychopharmacology, 1989
The endogenous opioid system plays an important role in the control of feeding behavior. Previous research has shown that antagonism of endogenous opioids will suppress feeding in certain models in both human and infrahuman species. In the current study, 16 normal-weight bulimic women were treated with low-dose naltrexone, the long-acting, orally ...
J E, Mitchell +6 more
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The endogenous opioid system plays an important role in the control of feeding behavior. Previous research has shown that antagonism of endogenous opioids will suppress feeding in certain models in both human and infrahuman species. In the current study, 16 normal-weight bulimic women were treated with low-dose naltrexone, the long-acting, orally ...
J E, Mitchell +6 more
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Pharmaceutical Development and Technology, 2012
Multivesicular liposomes containing naltrexone hydrochloride (DepoNTX) was prepared by using the traditional DepoFoam technology and the key formulation factors on encapsulation efficiency and particle size were investigated. A morphological characterization and in vitro/in vivo release assay was also carried out.
Lijun, Sun +4 more
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Multivesicular liposomes containing naltrexone hydrochloride (DepoNTX) was prepared by using the traditional DepoFoam technology and the key formulation factors on encapsulation efficiency and particle size were investigated. A morphological characterization and in vitro/in vivo release assay was also carried out.
Lijun, Sun +4 more
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Naltrexone hydrochloride (Trexan): a review of serum transaminase elevations at high dosage.
NIDA research monograph, 1986In summary, evidence is presented associating typically asymptomatic and reversible elevations of serum transaminase values with high daily dosages of naltrexone. Statistical significance was found only between placebo and the 300 mg dosage. Subjects aged 40 years and over were significantly more likely to develop this finding than younger subjects ...
D N, Pfohl +6 more
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