Results 51 to 60 of about 15,050 (215)

Review of real-world evidence of dual inhibition of VEGF-A and ANG-2 with faricimab in NAMD and DME

International Journal of Retina and Vitreous
Management of vitreoretinal disorders (e.g., neovascular age-related macular degeneration [nAMD] and diabetic macular edema [DME]) have assumed the standard therapy of lifelong anti-VEGF injections with drugs like aflibercept, brolucizumab, ranibizumab ...
Fernando M Penha, Maliha Masud, Zoha A. Khanani, Mathew J. Thomas, Rodney D Fong, Kyler Smith, Avishay Chand, Majid Khan, G. Gahn, G. Melo, A. Khanani   +10 more
semanticscholar   +1 more source

بررسی آلودگی منابع آبی مجموعه معدنی ذغالسنگ طزره با توجه به خصوصیات ژئوشیمیائی منطقه [PDF]

نشریه مهندسی معدن, 2011
معدن‌کاری ذغال‌سنگ، تعادل ژئوشیمیایی اولیه واحدهای سنگی را بر هم می‌زند و با تغییریافتن شرایط اکسیداسیون  محیط، عناصر موجود در لایه‏های ذغالی و سنگ‌های دربرگیرنده‏ آن‌ها آزاد شده و وارد محیط می‏گردند.
مرتضی رحیمی, بهناز دهرآزما, احمد خدادادی, فرج الله فردوست   +3 more
doaj  

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

Immunity & Ageing, 2020
Background Previously, we and others have reported higher populations of circulating neutrophils in patients with neovascular age-related macular degeneration (nAMD).
Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy, Heping Xu   +7 more
doaj   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Effect of High-Density Lipoprotein Metabolic Pathway Gene Variations and Risk Factors on Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in China. [PDF]

PLoS ONE, 2015
To investigate the effect of genetic variants in the high-density lipoprotein (HDL) metabolic pathway and risk factors on neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in China.A total of 742 Chinese ...
Qingyu Meng, Lvzhen Huang, Yaoyao Sun, Yujing Bai, Bin Wang, Wenzhen Yu, Mingwei Zhao, Xiaoxin Li   +7 more
doaj   +1 more source

Laser‐Induced Ultrafast Magnetic Phase Transition in 2D Van Der Waals Antiferromagnetic Heterostructures

Advanced Science, EarlyView.
In this work, ultrafast laser‐induced spin transfer and spin relaxation dynamics in 2D van der Waals antiferromagnetic CrI3/CrGeTe3 heterostructures are investigated. Laser excitation is demonstrated to induce pronounced interlayer nonequilibrium spin dynamics and ultrafast magnetic moment reconstruction, driving a transition from an antiferromagnetic (
Yang Wu, Fulu Zheng, San‐Dong Guo, Thomas Frauenheim, Zhaobo Zhou, Junjie He   +5 more
wiley   +1 more source

Association of neutrophil-to-lymphocyte ratio and neutrophil activation with treatment response in neovascular AMD

AJO International
Purpose: The neutrophil-to-lymphocyte ratio (NLR) and alterations of activation surface markers on circulating neutrophils have been suggested to be involved in the pathogenesis of age-related macular degeneration (AMD).
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Kathrine Gotfredsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen   +6 more
doaj   +1 more source

Prevention Surpasses Treatment: 5-year Follow-Up, Cost-Utility, and Cost–Benefit of Zeaxanthin Therapy for Neovascular Age-Related Macular Degeneration

Ophthalmology and Therapy, 2023
Introduction Oral administration of zeaxanthin (Zx) 20 mg daily in patients with unilateral neovascular age-related macular degeneration (nAMD) treated with triple therapy (photodynamic therapy/intravitreal bevacizumab/intravitreal dexamethasone) reduced
Gary C. Brown, Melissa M. Brown, Dennis Gierhart, R. Joseph Olk   +3 more
doaj   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Providing a Safe and Effective Intravitreal Treatment Service: Strategies for Service Delivery

Clinical Ophthalmology, 2020
Winfried Amoaku,1 Clare Bailey,2 Louise Downey,3 Richard P Gale,4 Faruque Ghanchi,5 Robin Hamilton,6 Sajjad Mahmood,7 Geeta Menon,8 Jenny Nosek,9 Ian Pearce,10 Yit Yang11 1Academic Ophthalmology, Division of Clinical Neuroscience, University of ...
Amoaku W, Bailey C, Downey L, Gale RP, Ghanchi F, Hamilton R, Mahmood S, Menon G, Nosek J, Pearce I, Yang Y   +10 more
doaj