Results 21 to 30 of about 488 (104)
Utilizing NanoBRET technology to measure BRAF autoinhibition in live cells
, 2023 BRAF is frequently activated via mutation in human cancer and the RASopathy syndromes; however, for BRAF activation to occur, autoinhibitory interactions between the regulatory and catalytic domains must be relieved.
Morrison, D
core +2 more sources
(S)-3-(3-((7-Ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile
Molbank, 2022 The title compound (S)-3-(3-((7-ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile (2) was synthesized in five steps, starting from 4-chloro-7-iodo-9H-pyrimido[4,5-b]indole (3), and was characterized by 1H-NMR, 13C-NMR, MS and HPLC.
Stanislav Andreev +3 more
doaj +1 more source
Frontiers in Endocrinology, 2022 The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and there is
Elizabeth K. M. Johnstone +15 more
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Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators [PDF]
, 2022 G protein-coupled receptors (GPCRs) are widely therapeutically targeted, and recent advances in allosteric modulator development at these receptors offer further potential for exploitation.
Nicholas D. Holliday +7 more
core +1 more source
SGC-CAMKK2-1: A Chemical Probe for CAMKK2
Cells, 2023 The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed.
Carrow Wells +24 more
doaj +1 more source
Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET [PDF]
, 2023 Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis, proliferation and migration of vascular endothelial cells. It is well known that cardiovascular safety liability for a wide range of small molecule tyrosine kinase ...
Kilpatrick, Laura E. +7 more
core +1 more source
RBB4/7 protein-protein interaction with MTA2 and H3 -NanoBRET assay
, 2020 Experimental details for NanoBRET assay measuring protein-protein interaction of RBBP4/7 and MTA2 or histone H3 in cells.
Magdalena szewczyk +1 more
core +1 more source
, 2020 The methods for Open Lab Noteboooks post: "HDAC6 ubiquitin binding domain and ubiquitin/ISG15 interaction cell assay - NanoBRET".
Magdalena Szewczyk (2632948) +1 more
core +1 more source
Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes
Nature Communications, 2023 Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets.
Charles S. Lay +4 more
doaj +1 more source
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Lukas Grätz +5 more
doaj +2 more sources