Results 71 to 80 of about 488 (104)

Fig_Supp_TIFF – Supplemental material for High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms

, 2019
Supplemental material, Fig_Supp_TIFF for High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms by Hyun Yong Jin, Yanyan Tudor, Kaylee Choi, Zhifei Shao ...
Zhifei Shao (449780), Joseph G. McGivern (6332135), Hyun Yong Jin (3797251), Kaylee Choi (8155110), Antony Symons (8155113), Yanyan Tudor (2412958), Brian A. Sparling (2448451)   +6 more
core   +1 more source

Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators

Frontiers in Pharmacology
Targeting the human chemokine receptor (CXCR2) holds significant potential in treating inflammatory diseases and cancer. In this study, we investigate the biased properties of previously reported CXCR2 antagonists (i.e., the MVH compounds).
Brent Van Bosstraeten, Katrijn Boon, Max Van Hoof, Wim Dehaen, Martyna Szpakowska, Andy Chevigné, Dominique Schols, Steven De Jonghe, Tom Van Loy   +8 more
doaj   +1 more source

NanoBRET to probe ligand-receptor and receptor-receptor interactions in living cells [PDF]

Increasing evidence has revealed the role of G protein-coupled receptors (GPCRs) in the regulation of signalling responses via complex cross-talk mechanisms with the receptor tyrosine kinase (RTK) family of transmembrane receptors.
Carvalheira Alcobia, Diana
core   +2 more sources

AI and network biology for rational polypharmacology in signaling drug design: a review

npj Precision Oncology
The complexity of disease-causing signaling networks is indicative of the failure of single-target therapeutics to work, particularly because of feedback, redundancy and activation of compensatory responses.
Xuehao Li, Zhaoqi Wu, Te Fang, Jun Li, Danyang Li, Ximeng Zhang, Ling Liu, Liming Wang   +7 more
doaj   +1 more source

Agonist-specific FPR1 conformational change prevents receptor recycling and promotes targeted protein degradation

Acta Pharmaceutica Sinica B
Recycling of internalized cell surface receptors is critical for membrane transport and receptor-mediated signaling. Formyl peptide receptor 1 (FPR1) plays important roles in host defense and inflammatory tissue injury.
Junlin Wang, Qiwen Liao, Geng Chen, Yixin Chang, Hong Nie, Jiahong Lu, Richard D. Ye   +6 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

USP45-mediated deubiquitination of HIV-1 Tat regulates viral transcription and latency

Frontiers in Microbiology
The HIV-1 Tat protein is regulated by post-translational modifications, particularly ubiquitination, but the full spectrum of deubiquitinating enzymes (DUBs) controlling HIV-1 transcription remains incompletely understood.
Kei Miyakawa, Kei Miyakawa, Kei Miyakawa, Kei Miyakawa, Hiyori Okura, Yasuyoshi Hatayama, Yasuyoshi Hatayama, Mayuko Nishi, Mayuko Nishi, Hirokazu Kimura, Hiroyuki Yamamoto, Hideki Hasegawa, Hideki Hasegawa, Tetsuro Matano, Tetsuro Matano, Akihide Ryo, Akihide Ryo   +16 more
doaj   +1 more source

Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain

Communications Chemistry
Tripartite motif-containing protein 21 (TRIM21), and particularly its PRY-SPRY protein interaction domain, plays a critical role in the immune response by recognizing intracellular antibodies targeting them for degradation.
Yeojin Kim, Aleksandar Lučić, Christopher Lenz, Frederic Farges, Martin P. Schwalm, Krishna Saxena, Thomas Hanke, Peter G. Marples, Jasmin C. Aschenbrenner, Daren Fearon, Frank von Delft, Andreas Krämer, Stefan Knapp   +12 more
doaj   +1 more source

Proximity labeling reveals non-catalytic interactions between DPP9 and ubiquitin signaling complexes

Cellular and Molecular Life Sciences
Dipeptidyl peptidase 9 (DPP9) is an amino-peptidase with roles in immunity, DNA-repair, cell signaling, memory and neonatal survival; its dysregulation is linked to cancer and immune-related disorders.
Valentina Elena Wirtgen, Layla Saied, Samuel Zolg, Marta Campos Alonso, Bettina Mayer, Laura Donzelli, Ulrich Maurer, H. T. Marc Timmers, Klaus-Peter Knobeloch, Oded Kleifeld, Ruth Geiss-Friedlander   +10 more
doaj   +1 more source