Results 71 to 80 of about 1,238 (123)

Discovery of Structurally Distinct Covalent KRAS G12C Inhibitor Scaffolds Through Large-Scale In Silico Screening and Experimental Validation. [PDF]

Cancers (Basel)
Weiss GJ, Loftus JC, Mallery DW, Tran NL.   +3 more
europepmc   +1 more source

Restoring the 14-3-3/CRAF regulatory interaction in Noonan syndrome using molecular glues. [PDF]

Proc Natl Acad Sci U S A
Virta JM, Vickery HR, Konstantinidou M, Crawford MC, Pennings MAM, Ottmann C, Brunsveld L, Arkin MR.   +7 more
europepmc   +1 more source

Cellular Context Influences Kinase Inhibitor Selectivity. [PDF]

J Med Chem
Binder MJ, Bashore FM, Dunn Hoffman KK, Damgaard C, Slater M, Drewry DH, Robers MB, Axtman AD.   +7 more
europepmc   +1 more source

High-throughput assay for measuring target occupancy of covalent compounds: a case study with MK2. [PDF]

RSC Chem Biol
Wong JL, Manuia M, Gao S, Stoehr N, Boersig T, Vuong K, Jiang T, Cao J, Jia Y, King CC, Joslin J, Ofori L, Loren J, Bassi ZI.   +13 more
europepmc   +1 more source

NanoBRET-based detection of ligand-receptor interactions at the neuropeptide FF receptor 1. [PDF]

RSC Adv
Lentschat H, Beck-Sickinger AG.
europepmc   +1 more source

Correction: Discovery of fully synthetic FKBP12-mTOR molecular glues. [PDF]

Chem Sci
Deutscher RCE, Meyners C, Repity ML, Sugiarto WO, Kolos JM, Maciel EVS, Heymann T, Geiger TM, Knapp S, Lermyte F, Hausch F.   +10 more
europepmc   +1 more source

Development of a Chemical Probe to Enable Characterization of the Casein Kinase 1γ Subfamily. [PDF]

J Med Chem
Capener JL, Kramer TW, Bashore FM, Flory E, Li F, Strang BL, Axtman AD.   +6 more
europepmc   +1 more source

Identification and Validation of 3-Cyano-Quinoline Ligands Targeting Integrin-Linked Kinase (ILK). [PDF]

J Med Chem
Greco FA, Abdul Azeez KR, Mitrović M, Sivashanmugam SA, Schwalm MP, Preuss F, Chatterjee D, Morasch V, Mathea S, Hanke T, Müller S, Knapp S.   +11 more
europepmc   +1 more source

Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader. [PDF]

ACS Chem Biol
Azeez KRA, Saraswati H, Mosler T, Hanke T, Ho-Xuan H, Neder N, Sivashanmugam SA, Heinz M, Schwalm MP, Giuliani G, Rathore R, Kazi R, Kumar R, Mitrovic M, Prieto-Garcia C, Bailey HJ, Mathea S, Hummer G, Đikić I, Müller S, Stolz A, Krause DS, Knapp S.   +22 more
europepmc   +1 more source

Evaluating 7‑Aminopyrazolo[4,3‑<i>d</i>]pyrimidines as Human A₁ and A₃ Adenosine Receptor Antagonists. [PDF]

ACS Omega
Georgiou K, Lamprakopoulou M, Buthmann H, Böing S, Pousias A, Dexter A, Chew EXY, Huang X, Michalettou EI, Pearce A, Dotsikas Y, Pouli N, Marakos P, Kolocouris A, Ladds G, Lougiakis N.   +15 more
europepmc   +1 more source