Results 91 to 100 of about 1,298 (145)

Computational Discovery and Optimization of a Potent, Selective, and Drug-Like Scaffold for p38α Inhibition. [PDF]

Drug Des Devel Ther
Nelen J, Goettert MI, Forster M, Breuils L, Villalgordo-Soto JM, Laufer S, Pérez-Sánchez H.   +6 more
europepmc   +1 more source

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera. [PDF]

Nat Commun
Du J, Villemure E, Johnson M, Azumaya C, Gaspar CJ, Marsters S, Lawrence D, Foster S, Rohou A, Cheung TK, Rose CM, Garner T, Ro S, Clark K, Beresini MH, Braun MG, Rudolph J, Hsu P, Ashkenazi A.   +18 more
europepmc   +1 more source

Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues. [PDF]

J Am Chem Soc
Konstantinidou M, Vickery HR, Pennings MAM, Virta JM, Luo SY, Visser EJ, Bannier SD, Srikanth M, Cismoski SZ, Young LC, van den Oetelaar MCM, McCormick F, Ottmann C, Brunsveld L, Arkin MR.   +14 more
europepmc   +1 more source

Family wide screening platform for kinases using NanoBRET or ABPP technology

Family wide screening platform for kinases and one new family using NanoBRET or ABPP technology M24 ...
openaire   +1 more source

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular <i>Brucella</i> infection. [PDF]

mBio
Kang Y-S, Kirby JE.
europepmc   +1 more source

A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation. [PDF]

Nat Commun
Langousis G, Gainza P, Hunkeler M, Kapsitidou D, Donckele EJ, Annunziato S, Wiedmer L, Jones KFM, DeMarco B, Quan C, Bunker RD, Lumb KJ, Fasching B, Castle JC, Townson SA, Bonenfant D.   +15 more
europepmc   +1 more source

Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders. [PDF]

J Med Chem
Webb DT, Jones KL, Macabuag N, Bago R, Betts J, Bhattacharyya S, Clifton S, Tinson RAJ, Achara C, Gilbert S, Howell S, Drewry DH, Rogers R, Jones C, Ferguson KR, Bullock AN, Lindsay DM, Kerr WJ, Esmieu W.   +18 more
europepmc   +1 more source

Split Reporter Systems in Viral Protein-Protein Interactions and Multimerization: Mechanisms and Applications. [PDF]

Cells
Ahmad H, Masood F, Iqbal U, Shaltout M, Yukselten Y, Sutton RE.   +5 more
europepmc   +1 more source

Dissecting the Interaction Domains of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicase DDX3X and Search for Potential Inhibitors. [PDF]

Int J Mol Sci
Lodola C, Pallotta MM, Manetti F, Governa P, Crespan E, Maga G, Secchi M.   +6 more
europepmc   +1 more source