Results 101 to 110 of about 1,298 (145)

Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors. [PDF]

ACS Med Chem Lett
Yap JL, Lovett G, Mason JW, Tucker J, Boe D, Chen A, Coffman KJ, DaSilva J, Dickinson T, Frattini V, Guan Y, Guiraldelli MF, Hou XJ, Jasti J, Kenton NT, Machin-Rivera R, Marroquin L, McClendon CL, McLaughlin M, Pecora A, Robinson MC, Stock IA, Tria GS, Tuttle J, Young JA, Zhang L, Lee AA.   +26 more
europepmc   +1 more source

Bioluminescence-based assays for quantifying endogenous protein interactions in live cells. [PDF]

J Biol Chem
Niles AL, Dibble MRC, Machleidt T, Martino K, Swiatnicki MR, Vu EH, Schwinn MK.   +6 more
europepmc   +1 more source

Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry. [PDF]

Nat Struct Mol Biol
Annunziato S, Quan C, Donckele EJ, Lamberto I, Bunker RD, Zlotosch M, Schwander L, Murthy A, Wiedmer L, Staehly C, Matysik M, Gilberto S, Kapsitidou D, Wible D, De Donatis GM, Trenh P, SriRamaratnam R, Strande V, Lieberherr R, Lyon D, Steiner D, Silva J, Almeida R, Dolgikh E, DeMarco B, Tsai J, Sadok A, Zarayskiy V, Walter M, Tiedt R, Lumb KJ, Bonenfant D, Fasching B, Castle JC, Townson SA, Gainza P, Petzold G.   +36 more
europepmc   +1 more source

Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for <i>COL15A1</i> mRNA Degradation. [PDF]

J Am Chem Soc
Su X, Tong Y, Zanon PRA, Wang J, Tanaka T, Childs-Disney JL, Disney MD.   +6 more
europepmc   +1 more source

Potent Fluorescent Probe for Target-Engagement Studies of Allosteric Pyruvate Kinase Modulators. [PDF]

Angew Chem Int Ed Engl
Nilsson O, Valaka AP, Håversen L, Bogucka A, Köteles I, Brear P, Rutberg M, Gunnarsson A, Hyvönen M, Grøtli M.   +9 more
europepmc   +1 more source

Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent Ribonucleic Acid Modulation. [PDF]

J Am Chem Soc
Li C, Yang X, Shan J, Dickerson KA, Springer NA, Munshi NC, Batey RT, Disney MD.   +7 more
europepmc   +1 more source

Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A₁-Receptor That Maintains Its Orthosteric Binding Site's Availability to Bind Ligands. [PDF]

J Med Chem
Lin CY, Platt S, Goulding J, Briddon SJ, Kindon ND, Harwood CR, Lai CW, Kellam B, Hill SJ.   +8 more
europepmc   +1 more source

Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit. [PDF]

RSC Chem Biol
Hoffmann L, Lenz C, Farges F, Kimani SW, Dopfer J, Keller S, Schwalm MP, Holzmann H, Kraemer A, Dong A, Li F, Chau I, Halabelian L, Gstaiger M, Müller S, Knapp S, Němec V.   +16 more
europepmc   +1 more source

Development of Purine and Pyrrolopyrimidine Scaffolds as Potent, Selective, and Brain Penetrant NUAK1 Inhibitors. [PDF]

ACS Med Chem Lett
Aldred GG, Boffey HK, Willems HMG, Winpenny D, Scott H, Clarke JH, Andrews SP, Skidmore J.   +7 more
europepmc   +1 more source

An AKR1C3-activated kinase inhibitor prodrug. [PDF]

RSC Chem Biol
Li Z, Martinez M, Byun WS, Thathireddy A, Qiu T, Wang Y, Katzengruber L, Chouldjian A, Lu W, Ji W, Che J, Zhang T, Hinshaw SM, Gray NS.   +13 more
europepmc   +1 more source