Results 111 to 120 of about 12,080 (272)

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Electrochemical Valence‐Regulated Biomimetic Nanozymes for Breast Cancer Metabolism Inhibition and Potentiated Catalytic Immunotherapy

Exploration, EarlyView.
MnOx nanozymes face low tumoricidal activity and PD‐L1‐mediated immune attenuation. Electrochemically regulated M‐MnOx with high oxidase activity was TCM‐wrapped into TMO. TMO targets tumors, triggers ICD, activates cGAS‐STING, antagonizes PD‐L1, and suppresses tumor recurrence, providing new insights for Mn‐based nanomaterials.
You Pan, Wei Cai, Meng Suo, Xiangqin Meng, Shengxin Ye, Yuping Tan, Xianqing Wei, Mingpu Yang, Pengyuan Qi, Zihang Yu, Kelong Fan, Shipeng Ning   +11 more
wiley   +1 more source

Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation

Journal of Functional Biomaterials
Selenium nanoparticles (SeNPs) have specific properties that result from their biosynthesis particularities. Chitosan can prevent pathogenic biofilm development.
Naomi Tritean, Luminița Dimitriu, Ștefan-Ovidiu Dima, Marius Ghiurea, Bogdan Trică, Cristian-Andi Nicolae, Ionuț Moraru, Alina Nicolescu, Anisoara Cimpean, Florin Oancea, Diana Constantinescu-Aruxandei   +10 more
doaj   +1 more source

RESVERATROL NANOFORMULATION FOR CANCER CHEMOPREVENTION AND THERAPY

Cancer remains one of the leading causes of morbidity and mortality worldwide, and conventional chemotherapy is often limited by non-specific targeting, systemic toxicity, and poor therapeutic efficacy.
Kathirvel. B, L.V. Vigneshwaran, S. Abinayah, Muskan. K, Adhithya. S, Manikandan. C, Govindraj. C   +6 more
core   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Curcumin-based nanoformulation for the pyroptotic death of mda-mb-231 cells

Curcumin (CU), a diphenolic natural flavonoid, has been considered as a next-generation anticancer agent; however, its efficacy is hindered by poor selectivity and low bioavailability (<3 × 10–8 μM).
Nandi, Sourav Kumar, Mishra, Snehasis, Jana, Pulak, Ghosh, Chandan Kumar, Kundu, Sudip, Sahoo, Panchanan, Dutta, Moisilee, Begum, Roshni, Seikh, Asiful H., Chattopadhyay, Krishnananda   +9 more
core   +2 more sources

Mango Seed Valorization: Sustainable Source of Nutrients, Bioactives, and Value‐Added Applications

Food Chemistry International, EarlyView.
Highlighting mango seed as a valuable yet overlooked by‐product, promoting its utilization and reducing agroindustrial waste. ABSTRACT Mango (Mangifera indica L.) is one of the most widely cultivated tropical fruits, generating large quantities of by‐products during processing, with mango seed representing 20%–25% of the whole fruit weight ...
Priyanka Yadav, Mazia Ahmed, Unaiza Iqbal, Pinki Saini   +3 more
wiley   +1 more source

Development and Evaluation of Isoniazid Loaded Silk Fibroin Microsphere

Ars Pharmaceutica
Aim: Current experimental investigation is dedicated to prepare microspheres with small size and good sphericity by Phase Separation method using Isoniazid (INH) as model drug.
Narinder Singh, Surya Prakash Gautam, Harjaskaran, Amanjot, Lovepreet Singh, Ankit Verma, Shalu Rani   +6 more
doaj   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Emergence and impact of theranostic-nanoformulation of triple therapeutics for combination cancer therapy [PDF]

Cancer remains a major global health threat necessitating the multipronged approaches for its prevention and management. Traditional approaches in the form of chemotherapy, surgery, and radiotherapy are often encountered with poor patient outcomes ...
Rajora Amit Kumar, Rajora Manju, Singh Sukhvir, Zhang Hongbo, Ahire Eknath D., Bhattacharya Jaydeep   +5 more
core   +2 more sources