Results 81 to 90 of about 12,080 (272)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Nanoformulation of Herbal Extracts in Treatment of Neurodegenerative Disorders

Nanoformulation of Herbal Extracts in Treatment of Neurodegenerative ...
Pratik Mungekar, Pranav Ajeet Nerurkar
core   +2 more sources

Nanoengineered-based delivery systems to modulate CD4+ T cell responses in cancer: emerging paradigms in cancer immunotherapy

Frontiers in Pharmacology
BackgroundCD4+ T-cells play a pivotal role in cancer immunology, functioning as both tumor-suppressing and tumor-promoting agents depending on their differentiation and cytokine profiles.
Nekhat Shahreen, Anukrati Agnihotri, Asfi Rizwan, Faizul Hasan, Mohd Danish Ansari, Zarif Mohamed Sofian, Nur Akmarina B. M. Said, Kenneth K. W. To, Syed Mahmood, Syed Mahmood, Syed Mahmood, Syed Mahmood   +11 more
doaj   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Sampling Strategy: An Overlooked Factor Affecting Artificial Intelligence Prediction Accuracy of Peptides’ Physicochemical Properties

Advanced Intelligent Discovery, EarlyView.
This study reveals that sampling strategy (i.e., sampling size and approach) is a foundational prerequisite for building accurate and generalizable AI models in peptide discovery. Reaching a threshold of 7.5% of the total tetrapeptide sequence space was essential to ensure reliable predictions.
Meiru Yan, Ankeer Abuduhebaier, Haojin Zhou, Jiaqi Wang   +3 more
wiley   +1 more source

NANOFORMULATION DEVELOPMENT

The conventional drug delivery system has some limitations due to its less stability and more toxicity Therefore to overcome such problems the nanofomulations are developed. The Nano formulations are intended to improve the drug stability, drug solubility of drug in blood.
Padma Ladda, Sheela Thorat, Shraddha Bhosale, Snehal Name   +3 more
openaire   +2 more sources

Fabrication, Characterization, and Insecticidal Activity Evaluation of Emamectin Benzoate–Sodium Lignosulfonate Nanoformulation with pH-Responsivity

, 2019
By means of high-speed emulsification and ultrasonic dispersing, emamectin benzoate (EB)–sodium lignosulfonate (SL) nanoformulation (EBSLNf) with a particle size of 150–250 nm was developed by the electrostatic self-assembly of SL and EB.
Rui Lu (253432), Jun-An Xiao (1478809), Wei-Guo Li (65196), Hai-Yan Yuan (2058916), Yan-Min Huang (7508288), Jian-Guo Cui (697390), Chun-Fang Gan (7508282), Yang Jiang (46459), Ao Wu (7508285), Dong-Mei Mo (7508279), Xiang-Ying Li (1980199), Qiang Hu (122686)   +11 more
core   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Neuroprotection after transient middle cerebral artery occlusion in male rats using kojic acid nanostructured lipid carriers: A behavioral, biochemical, and histological study on hippocampal CA1 region

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that kojic acid–loaded nanostructured lipid carriers (KA‐NLC) provide significant neuroprotection in a male rat model of middle cerebral artery occlusion (MCAO)–induced stroke. Treatment with KA‐NLCs reduced cerebral edema, improved motor and coordination balance and neurological scores, and enhanced spatial and avoidance memory.
Mobina Gheibi, Erfan Ghadirzadeh, Javid Tebyani, Seyedeh Mohadeseh Moyaedi, Khadijeh Khezri, Majid Saeedi, Ali Siahposht‐Khachaki, Narges Karimi, Melika Pourhossein, Shiva Shadi, Sasan Shafiei, Atena Sharifi‐Razavi   +11 more
wiley   +1 more source

Evaluation of Antioxidant and Anti-Inflammatory Effects of a Nanoformulation Derived from Annurca Apple Callus Extract in an In Vitro Model of Iron Overload-Induced Inflammation

Antioxidants
Ferroptosis, a regulated form of cell death driven by iron accumulation and lipid peroxidation, contributes to oxidative stress-related skin damage. This study evaluates the antioxidant and anti-inflammatory effects of a nanoformulation derived from an ...
Federica Gubitosa, Laura Taramova, Stefanie Ho Yi Chan, Joan Liu, Daniele Fraternale, Vinood B. Patel, Satyanarayana Somavarapu, Lucia Potenza, Mohammed Gulrez Zariwala   +8 more
doaj   +1 more source