Results 71 to 80 of about 12,080 (272)

Bosutinib high density lipoprotein nanoformulation has potent tumour radiosensitisation effects

Journal of Nanobiotechnology, 2023
Disruption of the cell cycle is among the most effective approach to increase tumour cells’ radio-sensitivity. However, the presence of dose-limiting side effects hampers the clinical use of tyrosine kinase inhibitors targeting the cell cycle.
Pouya Dehghankelishadi, Parisa Badiee, Michelle F. Maritz, Nicole Dmochowska, Benjamin Thierry   +4 more
doaj   +1 more source

Biodegradable polymeric nanoformulation based on the antiprotozoal canthin-6-one

, 2011
The efficacy of antiprotozoal agents against intracellular infections is very often limited by an almost negligible access to the cellular level where the pathogens are hidden.
Gerardo Cebrián-Torrejón, José L. Arias, Cebrian-Torrejon, G., Fournet, Alain, Patrick Couvreur, Erwan Poupon, Poupon, E., Arias, J. L., Alain Fournet, Couvreur, P.   +9 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine

Molecules, 2020
The chloroquine family of antimalarials has a long history of use, spanning many decades. Despite this extensive clinical experience, novel applications, including use in autoimmune disorders, infectious disease, and cancer, have only recently been ...
David M. Stevens, Rachael M. Crist, Stephan T. Stern   +2 more
doaj   +1 more source

TEM1-targeting PEGylated PLGA shikonin nanoformulation for immunomodulation and eradication of ovarian cancer.

, 2022
Introduction: Tumor endothelial marker 1 (TEM1) is expressed by tumor vascular endothelial cells in various cancers. Methods: Here, we developed poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) PEGylated with polyethylene glycol (PEG) and ...
Li, C., Barar, J., Omidi, Y., Guo, Y., Sandaltzopoulos, R., Coukos, G., Matthaiou, E.I., Kandalaft, L.E.   +7 more
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

The Anti-Glioblastoma Effects of Novel Liposomal Formulations Loaded with Cannabidiol, Celecoxib, and 2,5-Dimethylcelecoxib

Pharmaceutics
Background/Objectives: Glioblastoma multiforme (GBM) therapy efficacy remains limited due to the poor blood-brain barrier-penetrating power of drugs as well as dysregulated cellular signaling pathways of tumor cells leading to drug resistance. Novel drug
Anna Rybarczyk, Aleksandra Majchrzak-Celińska, Ludwika Piwowarczyk, Violetta Krajka-Kuźniak   +3 more
doaj   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Insecticidal Potential of Aniba canelilla (H.B.K.) Mez Essential Oil Against Aedes aegypti: Larvicidal and Adulticidal Activities, Mechanism of Action, and Formulation Development

Plants
Control of Aedes aegypti, the primary vector of arboviruses such as dengue, Zika, and chikungunya, is increasingly difficult due to resistance to synthetic insecticides and environmental concerns.
Jefferson D. da Cruz, Maíra M. H. Almeida, Maria Athana M. Silva, Jefferson R. A. Silva, Fernando A. Genta, Ana Claudia F. Amaral   +5 more
doaj   +1 more source

Development of Zwitterionic Polypeptide Nanoformulation with High Doxorubicin Loading Content for Targeted Drug Delivery

, 2018
Much attention has been drawn to targeted nanodrug delivery systems due to their high therapeutic efficacy in cancer treatment. In this work, doxorubicin (DOX) was incorporated into a zwitterionic arginyl–glycyl–aspartic acid (RGD)-conjugated polypeptide
Weifeng Lin (2632705), Shengfu Chen (503876), Weifeng Lin, Liangbo Xu, Guanglong Ma, Haofeng Qian (5496767), Guanglong Ma (2632702), Zhefan Yuan (2632708), Elie Sidransky, Elie Sidransky (5496770), Liangbo Xu (5496773), Shengfu Chen, Haofeng Qian, Zhefan Yuan   +13 more
core   +1 more source