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Cross-regulation of the Nanog and Cdx2 promoters [PDF]

Cell Research, 2009
The first cell fate choice in the mammalian embryo, the segregation of the inner cell mass (ICM) and trophectoderm (TE), is regulated by the mutually antagonistic effects of the transcription factors, Oct4 and Cdx2, while the pluripotency factor, Nanog, is essential to specify the epiblast.
Lingyi Chen, Akiko Yabuuchi, Chi-Wei Lu   +2 more
exaly   +3 more sources

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Gene of the month: NANOG

Journal of Clinical Pathology, 2015
NANOG is the human ortholog of the mouse Nanog gene1 and is a member of the homeobox family of DNA binding transcription factors.2 NANOG plays an important role in the maintenance of pluripotency and self-renewal of human embryonic stem cells.3 ,4 Chambers et al 3 were the first researchers who identified this transcription factor and named it ...
Mireia, Mato Prado, Adam E, Frampton, Justin, Stebbing, Jonathan, Krell   +3 more
openaire   +2 more sources

Multiresponsive Supramolecular Nanogated Ensembles

Journal of the American Chemical Society, 2009
A new multiresponsive supramolecular nanogated ensemble has been developed by introducing beta-cyclodextrin (beta-CD) into polymer-grafted mesoporous silica. The cross-linked polymer produced by host-guest interaction between beta-CD and diazo-linker works as a gatekeeper to control the release of trapped molecules from hybrid materials.
Rui, Liu, Ying, Zhang, Pingyun, Feng
openaire   +2 more sources

Designing mega-ASICs in nanogate technologies

Proceedings of the 40th annual Design Automation Conference, 2003
This paper discusses challenges the designer faces in integrating entire system product designs, containing tens or even hundreds of millions of logic gates, into single chip solutions now within reach using circuit densities possible in the latest silicon technologies.
David E. Lackey, Paul S. Zuchowski, Jürgen Koehl   +2 more
openaire   +1 more source

NANOG Changes in Mouse Kidneys with Age

Rejuvenation Research, 2005
NANOG is essential for mouse and human embryonic stem cell (ESC) pluripotency and selfrenewal. It is also expressed in several adult murine tissues as shown by reverse transcriptase–polymerase chain reaction (RT-PCR) analysis. However, human NANOG transcripts have been isolated from adult bone marrow (EST; GenBank accession no. BF893620).
Quan-Jian, Yan, Xiang-Mei, Chen, Yu-Mei, Zhang, Yuansheng, Xie, Suo-Zhu, Shi, Bo, Fu, Quan, Hong, Guo-Shuang, Xu, Xue-Guang, Zhang, Han-Yu, Zhu, Di, Wu, Yang, Lu, Yun-Hui, Zhang   +12 more
openaire   +2 more sources

[Prokaryotic expression of Nanog gene and preparation of anti-Nanog antibody].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2012
To express Nanog fusion protein in Escherichia coli ( E.coli), and to prepare rabbit anti-mouse polyclonal antibodies to the Nanog fusion protein.Mouse Nanog gene was amplified from the pNA992 recombinant plasmid and inserted into pET-32a vector to construct a recombinant expression vector pET-32a-Nanog.
Jun, Li, Xiao-min, Wang, Zhong-ying, Dou, Yong, Li   +3 more
openaire   +1 more source

The Function of Nanog in Pluripotency

2011
The transcription factors Oct4, Sox2 and Nanog form a triumvirate of regulatory proteins governing efficient maintenance of pluripotent cell identity. However, in contrast to Oct4 and Sox2, whose protein levels are relatively constant in undifferentiated mouse ES cells, Nanog levels fluctuate widely.
Nicholas Mullin, Ian Chambers
openaire   +1 more source

Research progress of nanog gene in fish

Molecular Genetics and Genomics
Nanog is a crucial regulatory factor in maintaining the self-renewal and pluripotency of embryonic stem cells. It is involved in various biological processes, such as early embryonic development, cell reprogramming, cell cycle regulation, the proliferation and migration of primordial germ cells.
Miao Yu, Fangyuan Wang, Huihui Gang, Chuanhu Liu   +3 more
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nanoGe Presentation

Proceedings of the International Conference on Electrocatalysis for Energy Applications and Sustainable Chemicals, 2020
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Stereospecific NANOG PEST Stabilization by Pin1

Biochemistry
NANOG protein levels correlate with stem cell pluripotency. NANOG concentrations fluctuate constantly with low NANOG levels leading to spontaneous cell differentiation. Previous literature implicated Pin1, a phosphorylation-dependent prolyl isomerase, as a key player in NANOG stabilization.
Josephine C. Ferreon, Hai Minh Ta, Hyosuk Yun, Kyoung-Jae Choi, My Diem Quan, Phoebe S. Tsoi, Choel Kim, Chul Won Lee, Allan Chris M. Ferreon   +8 more
openaire   +2 more sources