Results 1 to 10 of about 8,090 (181)

Migration, invasion, and metastasis are mediated by P-Rex1 in neuroblastoma [PDF]

Frontiers in Oncology
Neuroblastoma accounts for approximately 15% of pediatric cancer-related deaths despite intensive multimodal therapy. This is due, in part, to high rates of metastatic disease at diagnosis and disease relapse.
Jillian C Jacobson, Jingbo Qiao, Dai H Chung   +2 more
exaly   +6 more sources

P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells

Cells, 2021
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates Rac-type small G proteins in response to the stimulation of a range of receptors, particularly G protein-coupled receptors (GPCRs), to control cytoskeletal dynamics and other Rac ...
Martin J Baker, David C Hornigold, Heidi C E Welch   +2 more
exaly   +5 more sources

P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity [PDF]

Frontiers in Immunology
IntroductionP-Rex1 is a guanine-nucleotide factor for the small GTPase Rac (Rac-GEF) that is known to mediate neutrophil migration and ROS production in response to the activation of GPCRs.
Priota Islam, Julia Y. Chu, Stephen A. Chetwynd, Rachael Walker, Phillip T. Hawkins, Heidi C. E. Welch   +5 more
doaj   +4 more sources

P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity

Cell Reports
Summary: We investigated the roles of Rac guanine-nucleotide exchange factor (Rac-GEF) P-Rex1 in glucose homeostasis using Prex1−/− and catalytically inactive Prex1GD mice. P-Rex1 maintains fasting blood glucose levels and insulin sensitivity through its
Julia Y Chu, Stephen A Chetwynd, Gemma K Kinsella   +2 more
exaly   +4 more sources

P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. [PDF]

PLoS ONE, 2013
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers.
Andrew D Campbell, Samuel Lawn, Lynn C McGarry, Heidi C Welch, Bradford W Ozanne, Jim C Norman   +5 more
doaj   +14 more sources

REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice [PDF]

Nature Communications, 2018
REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 ...
Cristina Gontan, Hegias Mira-Bontenbal, Aristea Magaraki, Catherine Dupont, Tahsin Stefan Barakat, Eveline Rentmeester, Jeroen Demmers, Joost Gribnau   +7 more
doaj   +2 more sources

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

Cell Reports
Summary: The guanine-nucleotide exchange factor (GEF) P-Rex1 mediates G protein-coupled receptor (GPCR) signaling by activating the small GTPase Rac. We show here that P-Rex1 also controls GPCR trafficking.
Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, Angeliki Malliri, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C.E. Welch   +11 more
doaj   +2 more sources

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 [PDF]

eLife
PIP3-dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a guanine-nucleotide exchange factor (GEF) for Rac.
Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John JG Tesmer   +7 more
doaj   +2 more sources

Rlim/Rnf12, Rex1, and X Chromosome Inactivation

Frontiers in Cell and Developmental Biology, 2019
RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
doaj   +2 more sources

P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease

Neurobiology of Disease, 2023
Laforin and Malin are two proteins that are encoded by the genes EPM2A and EPM2B, respectively. Laforin is a glucan phosphatase and Malin is an E3-ubiquitin ligase, and these two proteins function as a complex.
L. Kumarasinghe, M.A. Garcia-Gimeno, J. Ramirez, U. Mayor, J.L. Zugaza, P. Sanz   +5 more
doaj   +3 more sources