Results 31 to 40 of about 8,159 (227)

First insights on the retroelement Rex1 in the cytogenetics of frogs [PDF]

Molecular Cytogenetics, 2015
Bien que certains éléments transposables (ET) aient été trouvés dans les génomes séquencés des espèces de grenouilles, des études détaillées de ces éléments ont fait défaut. Dans ce travail, nous avons étudié l'occurrence de l'élément Rex1, qui est répandu chez les poissons, chez les anoures du genre Physalaemus.
Juliana Damieli Nascimento, Diego Baldo, Luciana Bolsoni Lourenço   +2 more
openaire   +3 more sources

CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation

RNA Biology, 2022
It has recently been shown that CFIm25, a canonical mRNA 3’ processing factor, could play a variety of physiological roles through its molecular function in the regulation of mRNA alternative polyadenylation (APA). Here, we used CRISPR/Cas9-mediated gene
Yi Ran, Shanshan Huang, Junjie Shi, Qiumin Feng, Yanhui Deng, Andy Peng Xiang, Chengguo Yao   +6 more
doaj   +1 more source

Rex1/Zfp42 as an epigenetic regulator for genomic imprinting [PDF]

Human Molecular Genetics, 2011
Zfp42/Rex1 (reduced expression gene 1) is a well-known stem-cell marker that has been duplicated from YY1 in the eutherian lineage. In the current study, we characterized the in vivo roles of Rex1 using a mutant mouse line disrupting its transcription.
Jeong Do, Kim, Hana, Kim, Muhammad B, Ekram, Sungryul, Yu, Christopher, Faulk, Joomyeong, Kim   +5 more
openaire   +2 more sources

Functional Analysis of Rex1 During Preimplantation Development [PDF]

Stem Cells and Development, 2012
Rex1/Zfp42 is a nuclear protein that is highly conserved in mammals, and widely used as an embryonic stem (ES) cell marker. Although Rex1 expression is associated with enhanced pluripotency, loss-of-function models recently described do not exhibit major phenotypes, and ...
Climent, M., Alonso-Martin, S., Perez-Palacios, R., Guallar, D., Benito, A.A., Larraga, A., Fernandez-Juan, M., Sanz, M., De Diego, A., Seisdedos, M.T., Muniesa, P., Schoorlemmer, J.   +11 more
openaire   +3 more sources

A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat

Stem Cell Reports, 2020
Summary: Rat embryonic stem cells (rESCs) are capable of contributing to all differentiated tissues, including the germ line in chimeric animals, and represent a unique, authentic alternative to mouse embryonic stem cells for studying stem cell ...
Stephen Meek, Jun Wei, Taeho Oh, Tom Watson, Jaime Olavarrieta, Linda Sutherland, Daniel F. Carlson, Angela Salzano, Tamir Chandra, Anagha Joshi, Tom Burdon   +10 more
doaj   +1 more source

Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells

Frontiers in Cell and Developmental Biology, 2022
Pluripotent cells are subject to much interest as a source of differentiated cellular material for research models, regenerative medical therapies and novel applications such as lab-cultured meat.
Oliver Brookes, Stephen D. Thorpe, Stephen D. Thorpe, Olga Rigby Evans, Michael C. Keeling, David A. Lee   +5 more
doaj   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways. [PDF]

Adv Sci (Weinh)
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Zhang W, Mao X, He Y, Jia Q, Zhao Y, Dai X, Li X, Sun S, Sheng X, Ding D, Shi Y, Gao Q, Shuai L.   +12 more
europepmc   +2 more sources

P-Rex1 – a multidomain protein that regulates neurite differentiation [PDF]

Journal of Cell Science, 2008
The Rac-GEF P-Rex1 promotes membrane ruffling and cell migration in response to Rac activation, but its role in neuritogenesis is unknown. Rac1 promotes neurite differentiation; Rac3, however, may play an opposing role. Here we report that in nerve growth factor (NGF)-differentiated rat PC12 cells, P-Rex1 localised to the distal tips of developing ...
Joanne E, Waters, Megan V, Astle, Lisa M, Ooms, Demis, Balamatsias, Rajendra, Gurung, Christina A, Mitchell   +5 more
openaire   +2 more sources

Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells [PDF]

BMC Developmental Biology, 2008
Abstract Background Rex1/Zfp42 has been extensively used as a marker for the undifferentiated state of pluripotent stem cells. However, its function in pluripotent stem cells including embryonic stem (ES) cells remained unclear although its involvement in visceral endoderm differentiation in F9 ...
Masui, Shinji, Ohtsuka, Satoshi, Yagi, Rika, Takahashi, Kadue, Ko, Minoru SH, Niwa, Hitoshi   +5 more
openaire   +2 more sources

P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment

Frontiers in Oncology, 2022
Systematic analysis of tumor transcriptomes, combined with deep genome sequencing and detailed clinical assessment of hundreds of patients, constitutes a powerful strategy aimed to identify potential biomarkers and therapeutic targets to guide ...
Yarely Mabell Beltrán-Navarro, Guadalupe Reyes-Cruz, José Vázquez-Prado   +2 more
doaj   +1 more source