Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency [PDF]
Stem Cells, 2013 Abstract Reduced expression 1 (REX1) is a widely used pluripotency marker, but little is known about its roles in pluripotency. Here, we show that REX1 is functionally important in the reacquisition and maintenance of pluripotency.
Mi-Young Son +2 more
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Roles of the Rlim–Rex1 axis during X chromosome inactivation in mice [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2023 In female mice, the gene dosage from X chromosomes is adjusted by a process called X chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) that silences the paternally inherited X chromosome (Xp) is initiated at the 2- to 4-cell stages.
Feng Wang +2 more
exaly +5 more sources
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses [PDF]
Life Science AllianceThe E3 ubiquitin ligase RNF12/RLIM is mutated in intellectual disability and controls developmental gene expression. We show that chromatin targeting of RNF12 is required for substrate ubiquitylation and transcriptional responses, providing insight into ...
Carmen Espejo-Serrano +11 more
doaj +2 more sources
Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils [PDF]
Molecular Pharmacology, 2020 Jennifer N Cash +2 more
exaly +2 more sources
REX1, a Novel Gene Required for DNA Repair [PDF]
Journal of Biological Chemistry, 2003 Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage in most organisms. Using insertional mutagenesis, we isolated a UV-sensitive mutant of Chlamydomonas reinhardtii that is blocked in the excision of cyclobutane pyrimidine dimers. The mutant is also sensitive to the alkylating agent, methyl methanesulphonate. We have
Belgin Cenkci +2 more
openalex +4 more sources
P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity [PDF]
Baker MJ +10 more
europepmc +2 more sources
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis [PDF]
Nature Communications, 2011 Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular pathways that drive melanoblast migration in development are believed to underpin the movement and ultimately the metastasis of melanoma.
Colin R. Lindsay +33 more
+7 more sources
Betaglycan sustains HGF/Met signaling in lung cancer and endothelial cells promoting cell migration and tumor growth [PDF]
HeliyonPersistent HGF/Met signaling drives tumor growth and dissemination. Proteoglycans within the tumor microenvironment might control HGF availability and signaling by affecting its accessibility to Met (HGF receptor), likely defining whether acute or ...
Rodolfo Daniel Cervantes-Villagrana +7 more
doaj +2 more sources
P-Rex1 Regulates Neutrophil Function [PDF]
Current Biology, 2005 Rac GTPases regulate cytoskeletal structure, gene expression, and reactive oxygen species (ROS) production. Rac2-deficient neutrophils cannot chemotax, produce ROS, or degranulate upon G protein-coupled receptor (GPCR) activation. Deficiency in PI3Kgamma, an upstream regulator of Rac, causes a similar phenotype.
Heidi C. E. Welch +12 more
openalex +4 more sources
Differential Sensitivity of P-Rex1 to Isoforms of G Protein βγ Dimers [PDF]
Journal of Biological Chemistry, 2005 P-Rex1 is a specific guanine nucleotide exchange factor (GEF) for Rac, which is present in high abundance in brain and hematopoietic cells. P-Rex1 is dually regulated by phosphatidylinositol (3,4,5)-trisphosphate and the Gbetagamma subunits of heterotrimeric G proteins. We examined which of the multiple G protein alpha and betagamma subunits activate P-
Linnia H. Mayeenuddin +2 more
openalex +4 more sources