P-Rex1 and P-Rex2 RacGEFs and cancer [PDF]
Biochemical Society Transactions, 2017 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger (P-Rex) proteins are RacGEFs that are synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and Gβγ subunits of G-protein-coupled receptors. P-Rex1 and P-Rex2 share similar amino acid sequence homology, domain structure, and catalytic function.
Nuthasuda Srijakotre +5 more
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Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor [PDF]
The Journal of biological chemistry, 2016 Morphology of migrating cells is regulated by Rho GTPases and fine-tuned by protein interactions and phosphorylation. PKA affects cell migration potentially through spatiotemporal interactions with regulators of Rho GTPases. Here we show that the endogenous regulatory (R) subunit of type I PKA interacts with P-Rex1, a Rac guanine nucleotide exchange ...
Lydia Chávez‐Vargas +9 more
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Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]
Письма в Вавиловский журнал генетики и селекции, 2022 The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E. +2 more
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Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis. [PDF]
Biomed Res Int, 2023 Hameed AR +7 more
europepmc +3 more sources
P-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis
Frontiers in Pharmacology, 2021 Pulmonary fibrosis is a kind of interstitial lung disease with progressive pulmonary scar formation, leading to irreversible loss of lung functions. The TGF-β1/Smad signaling pathway plays a key role in fibrogenic processes.
Qing Liang +7 more
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The Influence of Different Anatomical Sites on the Characteristics and Differentiation Capacity of Rabbit Adipose-Derived Mesenchymal Stem Cells. [PDF]
Vet Med IntAdipose tissue possesses great potential for regenerative therapy, making it an important source of mesenchymal stem cells (MSCs). However, studies regarding the characteristics of rabbit adipose‐derived MSCs (Rab‐ADMSCs) obtained from various anatomical areas remain limited. This study aims to investigate the influence of different anatomical sites of
Kuncorojakti S +7 more
europepmc +2 more sources
REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. [PDF]
PLoS ONE, 2010 REX1/ZFP42 is a well-known embryonic stem cell (ESC) marker. However, the role of REX1, itself, is relatively unknown because the function of REX1 has only been reported in the differentiation of ESCs via STAT signaling pathways.
Dilli Ram Bhandari +5 more
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Demarcation of stable subpopulations within the pluripotent hESC compartment. [PDF]
PLoS ONE, 2013 Heterogeneity is a feature of stem cell populations, resulting from innate cellular hierarchies that govern differentiation capability. How heterogeneity impacts human pluripotent stem cell populations is directly relevant to their efficacious use in ...
Sonam Bhatia +3 more
doaj +1 more source
A Rac1-Independent Role for P-Rex1 in Melanoblasts [PDF]
Journal of Investigative Dermatology, 2015 No abstract available.
Lindsay, Colin R. +6 more
openaire +4 more sources