Results 41 to 50 of about 8,159 (227)

Finite size mean-field models [PDF]

, 2006
We characterize the two-site marginals of exchangeable states of a system of quantum spins in terms of a simple positivity condition. This result is used in two applications.
C Vandenplas, de Finetti B, Fukuda M Holevo A S, Hamermesh M, London F, M Fannes, Nielsen M A, Reichl L E   +7 more
core   +2 more sources

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42 [PDF]

Nucleic Acids Research, 2012
Rex1/Zfp42 is a Yy1-related zinc-finger protein whose expression is frequently used to identify pluripotent stem cells. We show that depletion of Rex1 levels notably affected self-renewal of mouse embryonic stem (ES) cells in clonal assays, in the absence of evident differences in expression of marker genes for pluripotency or differentiation.
Diana Guallar, Raquel Pérez-Palacios, María Climent, Ignacio Martínez-Abadía, Ana Larraga, Marta Fernández‐Juan, Carmen G. Vallejo, Pedro Muniesa, Jon Schoorlemmer   +8 more
openalex   +4 more sources

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +2 more sources

Epigenetic regulation of REX1 expression and chromatin binding specificity by HMGNs [PDF]

Nucleic Acids Research, 2019
HMGN proteins localize to chromatin regulatory sites and modulate the cell-type specific transcription profile; however, the molecular mechanism whereby these ubiquitous nucleosome binding proteins affect gene expression is not fully understood. Here, we show that HMGNs regulate the expression of Rex1, one of the most highly transcribed genes in mouse ...
Shaofei, Zhang, Tao, Deng, Wei, Tang, Bing, He, Takashi, Furusawa, Stefan, Ambs, Michael, Bustin   +6 more
openaire   +2 more sources

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite. [PDF]

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This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Miao J, Lucky AB, Ning G, Xia X, Liang X, Siddiqui F, Min H, Wang C, Li X, Zhou ZH, Cui L.   +10 more
europepmc   +2 more sources

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

A model of membrane contraction predicting initiation and completion of bacterial cell division [PDF]

, 2013
Bacterial cell division involves a complex and dynamic sequence of events whereby polymers of the protein FtsZ assemble at the division plane and rearrange to achieve the goal of contracting the cell membrane at the site of cell division, thus dividing ...
Alison Rodger, Anderson, Astumian, Astumian, Beuria, Bi, Bramhill, Bramhill, Caplan, Chen, Chen, Chen, Claire E. Dow, Corbin, Culbertson, David I. Roper, de Boer, Den Blaauwen, Erickson, Erickson, Feucht, Hale, Haney, Huecas, Hugo A. van den Berg, Hörger, Hörger, Lan, Li, Liu, Lu, Lu, Lutkenhaus, Löwe, Margolin, Martos, Mateos-Gil, Maupin, Mingorance, Mukherjee, Mukherjee, Oliva, Osawa, Pacheco-Gómez, Pichoff, Pla, RayChaudhuri, Romberg, Romberg, Rueda, Scheffers, Scheffers, Schmidt, Small, Stricker, Sun, Surovtsev, Surovtsev, Taschner, Turner   +59 more
core   +1 more source

P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer [PDF]

Oncotarget, 2018
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (P-Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding protein widely implicated in actin cytoskeleton reorganization. This Guanine nucleotide Exchange Factor (GEF) is overexpressed in human luminal breast cancer, and its expression associates ...
Barrio-Real, Laura, Lopez-Haber, Cynthia, Casado, Victoria, Goglia, Alexander G., Toettcher, Jared E., Caloca, María J., Kazanietz, Marcelo G.   +6 more
openaire   +3 more sources