Results 61 to 70 of about 8,159 (227)
EFFECTS OF P-REX1 OVEREXPRESSION ON MAMMARY DEVELOPMENT AND CANCER
, 2020 P-Rex1 is a protein which show negligible expression in normal breast tissue but is upregulated in the luminal subtype of breast cancer. This thesis examined the effects of increased P-Rex1 expression in mammary epithelial cells of mice and demonstrated that P-Rex1 can play a causal role in driving mammary tumour development. Furthermore, expression of
Nuthasuda Srijakotre
openalex +2 more sources
Taking U out, with two nucleases?
BMC Bioinformatics, 2006 Background REX1 and REX2 are protein components of the RNA editing complex (the editosome) and function as exouridylylases. The exact roles of REX1 and REX2 in the editosome are unclear and the consequences of the presence of two related proteins are not
Worthey Elizabeth A +2 more
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The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 Rrp6 is a conserved catalytic subunit of the eukaryotic nuclear exosome ribonuclease complex that functions in the productive 3' end maturation of stable RNAs, the degradation of transiently expressed noncoding transcripts and in discard pathways that ...
Monika Feigenbutz +3 more
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Rho Family GTPases and Rho GEFs in Glucose Homeostasis
Cells, 2021 Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF ...
Polly A. Machin +3 more
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Multisite phosphorylation of P-Rex1 by protein kinase C
Oncotarget, 2016 P-Rex proteins are guanine nucleotide exchange factors (GEFs) that act on the Rho/Rac family of GTP binding proteins. The activity of P-Rex proteins is regulated by several extracellular stimuli. In fact, activation of growth factor receptors has been reported to activate a phosphorylation/dephosphorylation cycle of P-Rex1.
Montero, Juan Carlos +3 more
openaire +4 more sources
P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer
Cell Reports, 2016 Autocrine VEGF signaling is critical for sustaining prostate and other cancer stem cells (CSCs), and it is a potential therapeutic target, but we observed that CSCs isolated from prostate tumors are resistant to anti-VEGF (bevacizumab) and anti-VEGFR ...
Hira Lal Goel +6 more
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Journal of Structural Biology: X, 2019 P-Rex family Rho guanine-nucleotide exchange factors are important regulators of cell motility through their activation of a subset of small GTPases. Both P-Rex1 and P-Rex2 have also been implicated in the progression of certain cancers, including breast
Jennifer N. Cash +2 more
doaj +1 more source
Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming [PDF]
, 2014 The detailed mechanism of reprogramming somatic cells into induced pluripotent stem cells (iPSCs) remains largely unknown. Partially reprogrammed iPSCs are informative and useful for understanding the mechanism of reprogramming but remain technically ...
Ayakawa Daisuke +12 more
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Comparative cytogenetics among Leporinus friderici and Leporellus vittatus populations (Characiformes, Anostomidae): focus on repetitive DNA elements [PDF]
Comparative Cytogenetics, 2019 Anostomidae are a neotropical fish family rich in number of species. Cytogenetically, they show a conserved karyotype with 2n = 54 chromosomes, although they present intraspecific/interspecific variations in the number and chromosomal location of ...
Thais Aparecida Dulz +6 more
doaj +3 more sources
LTR-retrotransposons in R. exoculata and other crustaceans [PDF]
, 2013 Transposable elements are major constituents of eukaryote genomes and have a great impact on genome structure and stability. They can contribute to the genetic diversity and evolution of organisms. Knowledge of their distribution among several genomes is
Bonnivard, Eric +5 more
core +1 more source