Results 81 to 90 of about 8,159 (227)

Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity [PDF]

, 2015
Much of development and disease concerns the generation of gene expression differences between related cells sharing similar niches. However, most analyses of gene expression only assess population and time-averaged levels of steady-state transcription ...
Cannon, D, Chubb, JR, Corrigan, AM, McDonel, P, Miermont, A   +4 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

Genome Biology, 2021
Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon, Adrian Janiszewski, Bart Theeuwes, Thomas Lefevre, Juan Song, Greet Bervoets, Lotte Vanheer, Natalie De Geest, Suresh Poovathingal, Ryan Allsop, Jean-Christophe Marine, Florian Rambow, Thierry Voet, Vincent Pasque   +13 more
doaj   +1 more source

YY2 in Mouse Preimplantation Embryos and in Embryonic Stem Cells

Cells, 2021
Yin Yang 2 encodes a mammalian-specific transcription factor (YY2) that shares high homology in the zinc finger region with both YY1 and REX1/ZFP42, encoded by the Yin Yang 1 and Reduced Expression Protein 1/Zinc Finger Protein 42 gene, respectively.
Raquel Pérez-Palacios, María Climent, Javier Santiago-Arcos, Sofía Macías-Redondo, Martin Klar, Pedro Muniesa, Jon Schoorlemmer   +6 more
doaj   +1 more source

Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]

, 2017
Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina, De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Duggal, Galbha, Heindryckx, Björn, Lierman, Sylvie, Menten, Björn, Mestdagh, Pieter, Peelman, Luc, Popovic, Mina, Sutherland, Ella, Taelman, Jasin, Tilleman, Laurentijn, Van der Jeught, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Vandesompele, Jo, Warrier, Sharat   +18 more
core   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

The Phase Structure of Supersymmetric Sp(2N_c) Gauge Theories with an Adjoint [PDF]

, 2009
We study the phase structure of N = 1 supersymmetric Sp(2N_c) gauge theories with 2N_f fundamentals, an adjoint, and vanishing superpotential. Using a-maximization, we derive analytic expressions for the values of N_f below which the first several gauge ...
A.E. Nelson, A.E. Nelson, C. Csáki, D. Kutasov, D. Kutasov, D. Poland, David Poland, H.D. Kim, J. Terning, K.A. Intriligator, M. Schmaltz, N.J. Craig, R. Kitano, S. Kachru, Y. Nomura   +14 more
core   +2 more sources

Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements

BMC Biology, 2018
Background Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-functionalization, also requires the ...
Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloé Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen, Amaury Herpin   +11 more
doaj   +1 more source

Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency [PDF]

, 2014
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts are characterised by their ability to self-renew and their potential to differentiate into many different cell types.
Chong, Yew Mei, Collins, James J., Feng, Bo, Lee, Yun Hwa, Li, Hu, Loh, Yuin Han, Ma, Hui, Ng, Hui Min, Teh, Xiuwen, Wu, Qiang, Yang, Henry   +10 more
core   +2 more sources

A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability [PDF]

, 2016
Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the Striking features of this parasite is its ability to remodel and decrease the deformability of host red blood cells, a ...
Brown, Christopher L., da Silva, Fabio L., Dalton, John P., Dixon, Matthew W. A., Gardiner, Donald L., Jones, Malcolm K., Lovas, Erica, Skinner-Adams, Tina S., Stack, Colin M., Taran, Elena, Teuscher, Franka, Tilley, Leann, Trenholme, Katharine R.   +12 more
core   +1 more source