Results 91 to 100 of about 8,159 (227)
Characterization of a P-Rex1 gene signature in breast cancer cells
Oncotarget, 2016 The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by stimulation of ErbB and other tyrosine-kinase receptors.
Barrio Real, Laura +4 more
openaire +6 more sources
Stem Cells International, 2016 Pluripotent stem cells (PSCs) fall in two states, one highly undifferentiated, the naïve state, and the primed state, characterized by the inability to contribute to germinal lineage. Several reports have demonstrated that these states can be modified by
Luis F. Malaver-Ortega +3 more
doaj +1 more source
EXPRESSION OF PLURIPOTENCY MARKERS IN REPROGRAMMING WITH TRANSPOSON SYSTEM MURINE FIBROBLASTS [PDF]
Biotechnologia Acta, 2013 The search for effective and safe methods to generate induced pluripotent stem cells is especially urgent. In the paper murine embryonic fibro blasts were reprogrammed towards actively proliferating colonies with typical induced pluripotent stem cells ...
S. V. Malysheva +2 more
doaj +1 more source
Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells
Stem Cell Reports, 2016 ZSCAN4 is a DNA-binding protein that functions for telomere elongation and genomic stability. In vivo, it is specifically expressed at the two-cell stage during mouse development. In vitro, it is transiently expressed in mouse embryonic stem cells (ESCs),
Yoko Nakai-Futatsugi, Hitoshi Niwa
doaj +1 more source
CryoSift: an accessible and automated CNN‐driven tool for cryo‐EM 2D class selection
Acta Crystallographica Section F, Volume 81, Issue 12, Page 517-526, December 2025.CryoSift is a CNN‐based tool that assesses the quality of 2D class averages. The incorporation of CryoSift into cryoSPARC workflows enables automated particle‐stack cleaning.Single‐particle cryo‐electron microscopy (cryo‐EM) has become an essential tool in structural biology.
Jan-Hannes Schäfer +8 more
wiley +1 more source
, 2009 In this work, we prove that a positive secure degree of freedom is achievable for a large class of Gaussian channels as long as the channel is not degraded and the channel is fully connected.
He, Xiang, Yener, Aylin
core +2 more sources
Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
Aging Cell, Volume 24, Issue 11, November 2025.Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury‐induced dedifferentiation and OSKM reprogramming, while emphasizing safety challenges and the need for precise spatiotemporal control to enable clinical translation.
Beom‐Ki Jo +4 more
wiley +1 more source
Response to BMP4 signalling during ES cell differentiation defines intermediates of the ectoderm lineage [PDF]
, 2010 The formation and differentiation of multipotent precursors underlies the generation of cell diversity during mammalian development. Recognition and analysis of these transient cell populations has been hampered by technical difficulties in accessing ...
Beddington +50 more
core +2 more sources
MedComm, Volume 6, Issue 10, October 2025.This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin +15 more
wiley +1 more source
, 2011 The medical and bioindustrial applications of pluripotent stem cells rely on our understanding of their biology. Pluripotent stem cell lines derived from embryos in different stages depend on distinct signalling pathways.
Chang, Kuo-Hsuan, Chang, Kuo-Hsuan
core +1 more source