Results 51 to 60 of about 8,159 (227)

P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site

International Journal of Breast Cancer, 2017
Background. Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) has been implicated in cancer growth, metastasis, and response to phosphatidylinositol 3-kinase (PI3K) inhibitor therapy. The aim of this study was to determine
Jonathan D. Marotti, Kristen E. Muller, Laura J. Tafe, Eugene Demidenko, Todd W. Miller   +4 more
doaj   +1 more source

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle

Communications Biology, 2022
PDGF reduces expression of nitric oxide-sensitive soluble guanylyl cyclase (NO-sGC) through PI3K-P-Rex1-Rac1 signaling in vascular smooth muscle cells.
Staffan Hildebrand, Mohamed Ibrahim, Andreas Schlitzer, Lars Maegdefessel, Wilhelm Röll, Alexander Pfeifer   +5 more
doaj   +1 more source

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal [PDF]

, 2013
Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self-renewal are unclear.
Alessia Gagliardi, Ambrosetti DC, Ambrosetti DC, Anastasia Felker, Anastasia I Kousa, Avilion AA, Bailey TL, Bogan AA, Brookes E, Chambers I, Chambers I, Chen X, Chen X, Costa Y, DeLano WL, Dignam JD, Douglas Colby, Engelen E, Favaro R, Festuccia N, Fidalgo M, Florian Halbritter, Gao Z, Genzor CG, Halbritter F, Han JD, Harley VR, Hatano SY, Ho SN, Hooper M, Hutchins AP, Ian Chambers, Jang H, Jason T Weiss, Jauch R, Jepsen K, Jeroen Demmers, Karel Bezstarosti, Kim J, Laemmli UK, Lam CS, Liang J, Ma T, Marson A, Maruyama M, Masui S, McDonel P, Mitsui K, Moretto-Zita M, Mullin NP, Navarro P, Navarro P, Nicholas P Mullin, Noble SM, Pardo M, Parisi S, Perkins DN, Qin J, Raymond A Poot, Rebecca Favaro, Remenyi A, Reynolds N, Rogers MS, Rugg-Gunn PJ, Shi W, Silvia K Nicolis, Simon R Tomlinson, Singh AM, Smith AG, Surface LE, Ura H, van den Berg DL, Wang J, Wang Z, Whyte WA, Wu Q, Yates A, Yuan H, Zappone MV, Zi Ying Tan   +79 more
core   +1 more source

Retroposition and evolution of the DNA-binding motifs of YY1, YY2 and REX1 [PDF]

Nucleic Acids Research, 2007
YY1 is a DNA-binding transcription factor found in both vertebrates and invertebrates. Database searches identified 62 YY1 related sequences from all the available genome sequences ranging from flying insects to human. These sequences are characterized by high levels of sequence conservation, ranging from 66% to 100% similarity, in the zinc finger DNA ...
Kim, Jeong Do, Faulk, Christopher, Kim, Joomyeong   +2 more
openaire   +2 more sources

Impacts of Stress Caused by Copper Sulfate (CuSO4) on the Genome of the Tambaqui (Colossoma macropomum): Quantification of Rex1 and Heterochromatic Profile

Brazilian Archives of Biology and Technology, 2022
The transposable elements are known by their ability to move and integrate into the genome of the host organism. They are classified in retrotransposons class I, which has, as intermediate of the transposition, the RNA and retrotransposons class II ...
Hallana Cristina Menezes da Silva, Leila Braga Ribeiro, Adolfo José da Mota, Eliana Feldberg, Daniele Aparecida Matoso   +4 more
doaj   +1 more source

RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation [PDF]

, 2018
Summary: X-linked intellectual disability (XLID) is a heterogeneous syndrome affecting mainly males. Human genetics has identified >100 XLID genes, although the molecular and developmental mechanisms underpinning this disorder remain unclear.
Brandenburg, Lennart, Branigan, Emma, Bustos, Francisco, Chaugule, Viduth K., Findlay, Greg, Hay, Ronald, Knebel, Axel, Macartney, Thomas, Segarra Fas, Anna, Toth, Rachel, Walden, Helen   +10 more
core   +4 more sources

Xist and Tsix transcription dynamics is regulated by the X-to-autosome ratio and semistable transcriptional states [PDF]

, 2016
In female mammals, X chromosome inactivation (XCI) is a key process in the control of gene dosage compensation between Xlinked genes and autosomes.
Berge, D. (Derk) ten, Gribnau, J.H. (Joost), Grootegoed, J.A. (Anton), Kremers, G.J. (Gert-Jan), Lehmann, J. (Johannes), Loda, A. (Agnese), Loos, F. (Friedemann), Maduro, C.M. (Cheryl)   +7 more
core   +1 more source

Control of Saccharomyces cerevisiae pre-tRNA processing by environmental conditions. [PDF]

, 2016
tRNA is essential for translation and decoding of the proteome. The yeast proteome responds to stress and tRNA biosynthesis contributes in this response by repression of tRNA transcription and alterations of tRNA modification.
Boguta, Magdalena, Foretek, Dominika, Hopper, Anita K., Wu, Jingyan   +3 more
core   +2 more sources

Regulation of P-Rex1 by Phosphatidylinositol (3,4,5)-Trisphosphate and Gβγ Subunits [PDF]

Journal of Biological Chemistry, 2005
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation of P-Rex1 Rac-GEF activity by the lipid second messenger phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) and the Gbetagamma subunits of heterotrimeric G proteins. We show that a P-Rex1 mutant lacking the PH
Kirsti, Hill, Sonja, Krugmann, Simon R, Andrews, W John, Coadwell, Peter, Finan, Heidi C E, Welch, Phillip T, Hawkins, Len R, Stephens   +7 more
openaire   +2 more sources