Results 81 to 90 of about 2,893 (161)

459 Development of small molecules targeting an epigenetic modulator for pediatric neuroblastoma

Journal of Clinical and Translational Science
Objectives/Goals: The bromodomain PHD finger transcription factor (BPTF) is an oncogenic driver of neuroblastoma. Our objective is to pioneer the discovery of the first class of chemical compounds that engage the PHD finger of BPTF and inhibit its ...
Joseph McPherson, William Pomerantz, Molly Sneddon, Anang Shelat, Wenwei Lin, Taosheng Chen, Marcus Fischer, Natalia Tretyakova   +7 more
doaj   +1 more source

A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines

Vaccines
Background/Objectives: The recent COVID-19 pandemic caused by SARS-CoV-2 infection has highlighted the need for protocols for rapid development of efficient screening methods to search for the optimal mRNA vaccine structures against mutable viral agents.
Maria Rubtsova, Yuliana Mokrushina, Dmitry Andreev, Maria Poteshnova, Nikita Shepelev, Mariya Koryagina, Ekaterina Moiseeva, Diana Malabuiok, Yury Prokopenko, Stanislav Terekhov, Aleksander Chernov, Elena Vodovozova, Ivan Smirnov, Olga Dontsova, Alexander Gabibov, Yury Rubtsov   +15 more
doaj   +1 more source

Establishing a nanoluciferase-based assay as a high-throughput screening platform for therapeutics in congenital nephrotic syndrome

Journal of Pharmacological Sciences
Nephrin is crucial for the formation of the glomerular slit diaphragm, which is the final filtration barrier in the kidney. A mutation in the NPHS1 gene that codes for nephrin causes congenital nephrotic syndrome of the Finnish type (CNF). Most missense mutations render nephrin non-functional due to the defective nephrin trafficking to the cell ...
Haruki, Tsuhako, Mary Ann, Suico, Haruka, Kojima, Saki, Takahashi, Shunsuke, Tanigawa, Misato, Kamura, Ryoichi, Sato, Riko, Kato, Aimi, Owaki, Ryuichi, Nishinakamura, Tsuyoshi, Shuto, Hirofumi, Kai   +11 more
openaire   +2 more sources

A human H5N1 influenza virus expressing bioluminescence for evaluating viral infection and identifying therapeutic interventions

iScience
Summary: A multistate outbreak of highly pathogenic avian influenza virus (HPAIV) H5N1 in the United States dairy cattle was first reported on March 2024, followed by a zoonotic cattle-to-human virus transmission to a dairy farm worker in Texas.
Ramya S. Barre, Ruby A. Escobedo, Esteban M. Castro, Michal Gazi, Joshua D. Castro, Anastasija Cupic, Mahmoud Bayoumi, Nathaniel Jackson, Chengin Ye, Aitor Nogales, Roy N. Platt, Ricardo Carrion, Jr., Timothy J.C. Anderson, Adolfo García-Sastre, Ahmed Mostafa, Luis Martinez-Sobrido   +15 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Hesperetin and Naringenin promote glucagon-like peptide-1 secretion from L-cell through activation of TGR5 and alleviated type 2 diabetes. [PDF]

Front Pharmacol
Zhang CY, Wang ZL, Jiang ZJ, Kim H, Liu C, Wang H.   +5 more
europepmc   +1 more source

Co-Translational Incorporation of (<i>R</i>)- and (<i>S</i>)-β²-Hydroxyacids <i>In Vivo</i>: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases. [PDF]

J Am Chem Soc
Soni C, Pressimone M, Nair M, Szalay K, Hall M, Hamlish N, Solivan AC, Schepartz A, Chatterjee A.   +8 more
europepmc   +1 more source

High-throughput assay for measuring target occupancy of covalent compounds: a case study with MK2. [PDF]

RSC Chem Biol
Wong JL, Manuia M, Gao S, Stoehr N, Boersig T, Vuong K, Jiang T, Cao J, Jia Y, King CC, Joslin J, Ofori L, Loren J, Bassi ZI.   +13 more
europepmc   +1 more source

Rapid drug susceptibility testing of Mycobacterium tuberculosis against first-line drugs simultaneously all-in-one plate by using a novel high-sensitive reporter phage combined with the BACTEC MGIT 960 system. [PDF]

Infect Dis Poverty
Ma R, Zhang Y, Zhu M, Zhang M, Qian C, Wu J, Hu Z, Guo M, Fan XY.   +8 more
europepmc   +1 more source