Results 91 to 100 of about 37,057 (264)

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing

, 2021
Harriet D. Gliddon, Dan Frampton, Vanisha Munsamy, Jude Heaney, Thomas Pataillot-Meakin, Eleni Nastouli, Alexander S. Pym, Adrie J C Steyn, Deenan Pillay, Rachel A. McKendry, Harriet D. Gliddon, Dan Frampton, Vanisha Munsamy, Jude Heaney, Thomas Pataillot-Meakin, Eleni Nastouli, Alexander S. Pym, Adrie J C Steyn, Deenan Pillay, Rachel A. McKendry   +19 more
openalex   +1 more source

CLAE: A High‐Fidelity Nanopore Sequencing Strategy for Read‐Level Viral Variant Detection and Environmental RNA Virus Discovery

Advanced Science, EarlyView.
High‐fidelity Nanopore sequencing offers a cost‐effective, portable path to uncovering viral dark matter in complex environments—but suffers from severe read‐length bias, low throughput, and limited accuracy. This study traces these limitations to core biochemical barriers and introduces CLAE, a foundational high‐fidelity platform that enables accurate,
Hannah Yu, Sarah Golconda, Ga‐Eun Lee, Dantong Xue, Guillermo Domínguez‐Huerta, James M. Wainaina, Benjamin Bolduc, Shashanka Murthy, Shihyoung Kim, Seth Faith, Shan‐Lu Liu, Jiyoung Lee, Michael Oglesbee, Matthew B Sullivan, Sanggu Kim   +14 more
wiley   +1 more source

Fast-bonito: A faster deep learning based basecaller for nanopore sequencing

, 2021
Zhimeng Xu, Yuting Mai, Denghui Liu, Wenjun He, Xinyuan Lin, Chi Xu, Lei Zhang, Xin Meng, Joseph Mafofo, Walid Abbas Zaher, Ashish Koshy, Yi Li, Nan Qiao   +12 more
openalex   +1 more source

Medium‐Entropy Engineering Enhances Na⁺/Electron Transport in Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs Cathode for Sodium‐Ion Batteries

Advanced Science, EarlyView.
This study proposes a medium‐entropy strategy to enhance sodium vanadium fluorophosphate cathodes. The designed Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs composite enhances structural stability and charge transport. Entropy‐induced distortion and carbon nanotubes (CNTs) synergistically improve Na⁺/electron kinetics. In situ XRD reveals a reversible dual‐
Ju Yang, Najun Liu, Guanglu Jiang, Huili Peng, Kan Mi, Nana Wang, Zhongchao Bai, Xiaolei Jiang   +7 more
wiley   +1 more source

Benchmarking Ploidy Estimation Methods for Bulk and Single‐Cell Whole Genome Sequencing

Advanced Science, EarlyView.
It comprehensively benchmarks computational tools for ploidy estimation from bulk and single‐cell whole‐genome sequencing data. The results highlight the strengths and limitations of each method under different conditions and identify PURPLE and SeCNV show top performance in bulk and single‐cell settings, respectively.
Yawei Song, Zilv Mei, Qijie Zheng, Qingqing Yuan, Yu Liang, Jiaqi Gao, Lang Zhou, Shuheng Wu, Wei Wu   +8 more
wiley   +1 more source

Comparison of the performance of an amplicon sequencing assay based on Oxford Nanopore technology to real-time PCR assays for detecting bacterial biodefense pathogens

, 2020
Robert A. Player, Kathleen Verratti, Andrea Staab, Christopher Bradburne, Sarah E. Grady, Bruce G. Goodwin, Shanmuga Sozhamannan   +6 more
openalex   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Multiplexed nanopore sequencing of HLA-B locus in Māori and Polynesian samples [PDF]

, 2017
Kim N. T. Ton, Simone L. Cree, Sabine Gronert–Sum, Tony R. Merriman, Lisa K. Stamp, Martin A. Kennedy   +5 more
openalex   +1 more source

Deep Learning‐Powered Nanoplasmonic Biosensing Approach Enables Ultrasensitive Extracellular Vesicles Profiling for Cancer Screening

Advanced Science, EarlyView.
This study presents a Kolmogorov–Arnold network (KAN)‐powered nanoplasmonic biosensing platform for ultrasensitive detection of small extracellular vesicles in serum, enabling highly accurate pancreatic cancer screening. The method achieves an area under the curve (AUC) of 0.99 in a large clinical cohort, offering a robust and interpretable deep ...
Jiaheng Zhu, Yingqi Xiao, Xinyue Huang, Qiang Niu, Lihuang Zeng, Shaowei Lin, Mengqi Jiang, Tianhao Huang, Hanyang Chen, Yinong Xie, Yuan Gao, Wei Chen, Yiming Yan, Jiaqing Shen, Kaibin Chen, Yurong Dai, Zhipeng Zhang, Lijun Zeng, Yahong Chen, Boan Li, Jinfeng Zhu, Bo Li   +21 more
wiley   +1 more source

Producing Photoactivated Room Temperature Phosphorescent Glass from Bamboo

Advanced Science, EarlyView.
Room‐temperature phosphorescent (RTP) glass (B‐glass) is developed from natural bamboo. The as‐prepared B‐glass demonstrates unique photoactivated RTP characteristics and superior mechanical properties, which can serve as a reprogrammable platform for 3D luminescent architectures and multilevel optical data storage.
Shaodi Zhang, Yingxiang Zhai, Jingyi Zhou, Jie Wu, Jian Gan, Boyan Jiang, Yuxiang Huang, Xiaoqi Zhao, Yahui Zhang, Zhijun Chen   +9 more
wiley   +1 more source