Angewandte Chemie International Edition, EarlyView.Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber +21 more
wiley +1 more source
Novel lipid and ascorbyl stearate biomimetic vancomycin-loaded nanostructured lipid carrier therapy for bacterial infections and sepsis. [PDF]
RSC AdvNyandoro VO +6 more
europepmc +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Plant virus‐like particles (VLPs) are promising nanotechnology platforms, but their translation requires purification strategies suitable for large‐scale production. Here, we developed a nuclease‐free downstream process for Physalis mottle virus (PhMV) VLPs expressed in Escherichia coli, combining ammonium sulfate precipitation, low‐pH ...
Sean K. Hsu +3 more
wiley +1 more source
Development and preclinical evaluation of quiniodochlor-loaded nanostructured lipid carrier-chitosan gel for topical antifungal therapy. [PDF]
Discov NanoBiswas UK, Bose A, Naskar S, Jana M.
europepmc +1 more source
Copaifera langsdorffii Oleoresin-Loaded Nanostructured Lipid Carrier Emulgel Improves Cutaneous Healing by Anti-Inflammatory and Re-Epithelialization Mechanisms. [PDF]
Int J Mol Sci, 2023 Gushiken LFS +12 more
europepmc +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Therapeutic massage with nanostructured lipid carrier gel containing quercetin for muscle injury treatment in rats. [PDF]
Braz J Med Biol ResBellé JM +6 more
europepmc +1 more source
Dipeptide-1 modified nanostructured lipid carrier-based hydrogel with enhanced skin retention and topical efficacy of curcumin. [PDF]
RSC Adv, 2023 Yuan M +7 more
europepmc +1 more source
, 2011 Gene therapy is a pharmacological regimen of great interest for the treatment of genetic, neoplastic and infectious diseases. Recently, the use of lipid dispersions as gene delivery systems has attracted wide attention of worldwide formulators due to ...
RAVANI, Laura +6 more
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