Results 201 to 210 of about 1,198,510 (287)

Synthesis and characterization of chitosan-functionalized nanostructured lipid carriers with temozolomide: cytotoxic effects and chromosomal instability in human glioblastoma cells. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Negreiros HA, do Lago JPAD, de Oliveira VA, Silva LRA, de Melo ACL, de Sousa IGB, da Cruz Esteves J, Francisco SEMC, Paiva SL, Rodrigues JPCG, Carvalho LMM, de Souza PHO, Uchôa AFC, Cardoso ALMR, de Alencar Sales WF, da Silva Bastos MH, de Lima Feitoza L, Júnior DD, da Silva FCC, Xavier-Júnior FH, Ferreira PMP, de Castro E Sousa JM.   +21 more
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Engineering Optimized Nanostructured Lipid Carriers for Astaxanthin: A Response Surface Methodology Approach. [PDF]

Int J Nanomedicine
Abdol Wahab NR, Meor Mohd Affandi MMR, Fakurazi S, Alias E, Hassan H.   +4 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Enhanced encapsulation and membrane retention of <i>Teleogryllus mitratus</i> protein via hydrophobic ion-pairing in nanostructured lipid carriers. [PDF]

Int J Pharm X
Inthorn J, Somwongin S, Juntrapirom S, Kanjanakawinkul W, Heinz A, Müllertz A, Rades T, Chaiyana W.   +7 more
europepmc   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Design Evolution of Curcumin-Loaded Nanostructured Lipid Carriers: Formulation Strategies, Functional Modifications, and Mechanistic-Translational Perspectives. [PDF]

Int J Nanomedicine
Nurohman I, Suhandi C, Chaerunisaa AY, Wilar G, Jafar G, Sriwidodo S.   +5 more
europepmc   +1 more source

Smart Carbon Dot Nanomaterials: Emerging Structure, Properties, and Biomedical Insights—A Comprehensive Review

MetalMat, EarlyView.
This review presents recent advances in smart carbon dot (CD) nanomaterials, emphasizing their synthesis, structural design, fluorescence mechanisms, and biomedical applications. CDs, typically below 10 nm, exhibit tunable photoluminescence, excellent stability, and biocompatibility.
Trisita Ghosh, Palash Das, Narayan Chandra Das   +2 more
wiley   +1 more source

Nanostructured Lipid Carriers Containing Acridine Derivatives in the Application of Sonodynamic Therapy for the Treatment of Breast Cancer. [PDF]

ACS Omega
Costa KMN, Sato MR, de Moura RO, McHale AP, Callan JF, Oshiro-Junior JA.   +5 more
europepmc   +1 more source

Applications of nanocarrier‐delivered RNA interference in agricultural biological control (2009–2025)

New Plant Protection, EarlyView.
Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang, Woo‐Jong Hong, Xu Jiang, Ki‐hong Jung, Yuan Hu Xuan   +4 more
wiley   +1 more source