Results 1 to 10 of about 7,667 (145)

Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery [PDF]

Nanoscale Research Letters, 2011
1,3-Dicyclohexylurea (DCU), a potent soluble epoxide hydrolase (sEH) inhibitor has been reported to lower systemic blood pressure in spontaneously hypertensive rats.
Chiang Po-Chang, Ran Yingqing, Chou Kang-Jye, Cui Yong, Wong Harvey   +4 more
doaj   +3 more sources

Preparation, characterization and in vitro evaluation of atorvastatin nanosuspensions. [PDF]

PLoS ONE
Poorly water-soluble drugs present a significant challenge for pharmaceutical development, particularly affecting the pharmacokinetics of orally administered drugs due to their poor dissolution.
Yaman Ahmad Akour, Ahmad Aljaberi, Saja H Hamed, Alaa Altaher, Eman M Migdadi   +4 more
doaj   +2 more sources

A recent solidification approach for nanosuspension: formulation, optimisation and evaluation of canagliflozin immediate release pellets [PDF]

Folia Medica, 2022
Introduction: Canagliflozin is a BCS class IV drug. Nanosuspension is known to enhance the saturation solubility and dissolution rate of poorly soluble drugs owing to the increased surface area of nanosized particles. Aim: In the present
Nisha C. Patel, Hitesh A. Patel
doaj   +3 more sources

Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To enhance the pharmaceutical potential and oral bioavailability of quercetin contents of Allium cepa peel extract by novel nanosuspension technology.
Fatiqa Zafar, Nazish Jahan, Shaukat Ali, Saba Jamil, Riaz Hussain, Saba Aslam   +5 more
doaj   +1 more source

Development of Nanosuspension of Artemisia absinthium Extract as Novel Drug Delivery System to Enhance Its Bioavailability and Hepatoprotective Potential

Journal of Functional Biomaterials, 2023
A nanosuspension of Artemisia absinthium extract was formulated and characterized for the enhancement of bioavailability and better hepatoprotective efficacy. The nanosuspension of A.
Nazish Jahan, Fareeha Kousar, Khalil Ur Rahman, Syeeda Iram Touqeer, Naseem Abbas   +4 more
doaj   +1 more source

Nanosuspension enhances dissolution rate and oral bioavailability of Terminalia arjuna bark extract in vivo and in vitro

Asian Pacific Journal of Tropical Biomedicine, 2020
Objective: To enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract by formulating its nanosuspension. Methods: Nanoprecipitation approach was used for the formulation of nanosuspension using polysorbate-80 as a ...
Fatiqa Zafar, Nazish Jahan, Khalil-Ur-Rahman, Muhammad Rafique Asi, Waseeq-Ul-Islam Zafar   +4 more
doaj   +1 more source

Investigation of pre-clinical pharmacokinetic parameters of atovaquone nanosuspension prepared using a pH-based precipitation method and its pharmacodynamic properties in a novel artemisinin combination

Journal of Global Antimicrobial Resistance, 2020
Objectives: Recently, a growing resistance to antimalarial drugs such as chloroquine, sulfadoxine–pyrimethamine, artemisinin derivatives and mefloquine has been observed. The pharmacokinetic limitation of the current therapy and multi-drug resistance has
Harsha Kathpalia, Siddhesh Juvekar, Krishnapriya Mohanraj, Mrunal Apsingekar, Supriya Shidhaye   +4 more
doaj   +1 more source

Nanotechnology Approach for Exploring the Enhanced Bioactivities and Biochemical Characterization of Freshly Prepared Nigella sativa L. Nanosuspensions and Their Phytochemical Profile

Frontiers in Bioengineering and Biotechnology, 2022
Nigella sativa is one of the most commonly used medicinal plants as it exhibits several pharmacological activities such as antioxidant, antibacterial, anticancer, antidiabetic, and hemolytic.
Tayyab Ali, Fatma Hussain, Muhammad Naeem, Ajmal Khan, Ahmed Al-Harrasi   +4 more
doaj   +1 more source

Fluconazole Nanosuspension Enhances In Vitro Antifungal Activity against Resistant Strains of Candida albicans [PDF]

Pharmaceutical Sciences, 2022
Background: Recently, nanoparticles were widely used in drug delivery. Fluconazole (FLZ) is a lipid-soluble antifungal, which is utilized in treating fungal infections.
Katayoun Morteza-Semnani, Majid Saeedi, Jafar Akbari, Maryam Moazeni, Houman Seraj, Elham Daftarifard, Mahgol Tajbakhsh, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei   +8 more
doaj   +1 more source

Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity

Journal of Chemistry, 2020
Nanosuspensions are widely reported to enhance the solubility of poorly soluble drugs. In addition to enhancement in solubility, improvement of stability and therapeutic efficacy would be an added advantage.
Shadab Md, Nabil A. Alhakamy, Sohail Akhter, Zuhier A. Y. Awan, Hibah M. Aldawsari, Waleed S. Alharbi, Anzarul Haque, Hira Choudhury, Ponnurengam Malliappan Sivakumar   +8 more
doaj   +1 more source