Results 161 to 170 of about 4,959 (213)

Nanosuspension improves tretinoin photostability and delivery to the skin

International Journal of Pharmaceutics, 2013
The aims of this work were to improve cutaneous targeting and photostability of tretinoin by using nanosuspension formulation. Tretinoin is a drug widely used in the topical treatment of various dermatological diseases.
Chiara Sinico, Anna Maria Fadda, Francesco Corrias   +2 more
exaly   +2 more sources

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Paclitaxel nanosuspensions for targeted chemotherapy – nanosuspension preparation, characterization, and use

Pharmaceutical Development and Technology, 2013
The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic. Different particle coatings were employed to assess their impact on cellular uptake in vitro. In vivo work was then performed to demonstrate efficacy in tumor-bearing mouse models.Paclitaxel nanosuspensions were ...
Sarah E, Lee, Shawn F, Bairstow, Jane O, Werling, Mahesh V, Chaubal, Lawrence, Lin, Mary Ann, Murphy, James P, DiOrio, Jerome, Gass, Barrett, Rabinow, Xiaoen, Wang, Yong, Zhang, Zhijian, Yang, Robert M, Hoffman   +12 more
openaire   +2 more sources

Formulation aspects of intravenous nanosuspensions

International Journal of Pharmaceutics, 2020
Intravenous (IV) route is preferred for rapid onset of action, avoiding first pass metabolism and achieving site specific delivery. Development of IV formulations for poorly water soluble drugs poses significant challenges. Formulation approaches like salt formation, co-solvents, surfactants and inclusion complexation using cyclodextrins are used for ...
Dipeekakumari, Patel, Sandeep S, Zode, Arvind K, Bansal   +2 more
openaire   +2 more sources

Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats

Die Pharmazie, 2011
The purpose of the present study was to investigate the pharmacokinetics of hydroxycamptothecin nanosuspensions after intravenous administration in rats. Hydroxycamptothecin injection was studied parallelly. The results showed that AUC0→∞, MRT, t1/2(α) and t1/2(β) of hydroxycamptothecin nanosuspensions was significantly higher, while their total body ...
Lei, Wang, Hai-Ying, Hua, Wei-Jing, Liu, Yong-Xing, Zhao, Zhen-Zhong, Zhang   +4 more
openaire   +2 more sources

Stability of nanosuspensions in drug delivery

Journal of Controlled Release, 2013
Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth.
Yancai Wang, Ying Zheng, Ling Zhang, Qiwei Wang, Dianrui Zhang   +4 more
openaire   +2 more sources

Safety of nanosuspensions in drug delivery

Nanomedicine: Nanotechnology, Biology and Medicine, 2017
Nanosuspension technology is currently undergoing dramatic expansion in pharmaceutical science research and development. However, most of the research efforts generally focus on formulation and potential beneficial description, while the research into potential toxicological effects and implications (i.e., in vivo safety and health effects) is lacking.
Lulu Wang, Juan Du, Yuqi Zhou, Yancai Wang   +3 more
openaire   +2 more sources

Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor

European Journal of Pharmaceutical Sciences, 2012
Purpose: PIK75 is a specific inhibitor of the p110 α isoform of phosphatidylinositol-3-kinase, an enzyme which is upregulated in several human cancers. However its poor water solubility and stability has limited its pre-clinical development.
Sanjay Garg, Meghna Talekar, Jackie Kendall   +2 more
exaly   +2 more sources

Nanosuspensions of hesperetin: preparation and characterization

Die Pharmazie, 2014
Nanosuspensions are a smart formulation principle for dermal applications, as they increase the penetration of poorly soluble substances into the skin. Because microbial stability is a pre-requisite for dermal formulations, water containing formulations need to be preserved.
L, Al Shaal, P R, Mishra, R H, Müller, C M, Keck   +3 more
openaire   +2 more sources

Nanosuspension: Principles, Perspectives and Practices

Current Drug Delivery, 2016
In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose.
Sachin Kumar, Singh, Yogyata, Vaidya, Monica, Gulati, Sibasis, Bhattacharya, Varun, Garg, Narendra Kumar, Pandey   +5 more
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Preparation and Solidification of Redispersible Nanosuspensions

Journal of Pharmaceutical Sciences, 2014
To test the feasibility of preparing redispersible powders from nanosuspensions without further addition of drying protectants, Lovastatin was processed into nanosuspensions and subsequently converted into a powder form using a spray-drying process.
Xin, Zhang, Jian, Guan, Rui, Ni, Luk Chiu, Li, Shirui, Mao   +4 more
openaire   +2 more sources