Results 161 to 170 of about 4,453 (214)
Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials. [PDF]
Sitalaksmi RM +10 more
europepmc +1 more source
Nanosuspension improves tretinoin photostability and delivery to the skin
The aims of this work were to improve cutaneous targeting and photostability of tretinoin by using nanosuspension formulation. Tretinoin is a drug widely used in the topical treatment of various dermatological diseases.
Francesco Lai +2 more
exaly +2 more sources
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In vitro antitumor activity of silybin nanosuspension in PC-3 cells
The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method.
Yancai Wang +2 more
exaly +2 more sources
Evaluation of improved oral bioavailability of ritonavir nanosuspension
The main objective of this study was to evaluate the pharmacokinetics of ritonavir (RTV) nanosuspension in rats in both fed and fasted state in comparison with coarse powder, physical mixture and commercial product (Norvir (R)).
Alptug Karakucuk +2 more
exaly +2 more sources
Pharmaceutical Development and Technology, 2013
The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic. Different particle coatings were employed to assess their impact on cellular uptake in vitro. In vivo work was then performed to demonstrate efficacy in tumor-bearing mouse models.Paclitaxel nanosuspensions were ...
Sarah E, Lee +12 more
openaire +2 more sources
The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic. Different particle coatings were employed to assess their impact on cellular uptake in vitro. In vivo work was then performed to demonstrate efficacy in tumor-bearing mouse models.Paclitaxel nanosuspensions were ...
Sarah E, Lee +12 more
openaire +2 more sources
Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor
Purpose: PIK75 is a specific inhibitor of the p110 α isoform of phosphatidylinositol-3-kinase, an enzyme which is upregulated in several human cancers. However its poor water solubility and stability has limited its pre-clinical development.
Meghna Talekar +2 more
exaly +2 more sources
Formulation aspects of intravenous nanosuspensions
International Journal of Pharmaceutics, 2020Intravenous (IV) route is preferred for rapid onset of action, avoiding first pass metabolism and achieving site specific delivery. Development of IV formulations for poorly water soluble drugs poses significant challenges. Formulation approaches like salt formation, co-solvents, surfactants and inclusion complexation using cyclodextrins are used for ...
Dipeekakumari, Patel +2 more
openaire +2 more sources

