Results 171 to 180 of about 4,453 (214)
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Stability of nanosuspensions in drug delivery
Journal of Controlled Release, 2013Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth.
Yancai Wang +4 more
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Nanosuspension: Principles, Perspectives and Practices
Current Drug Delivery, 2016In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose.
Sachin Kumar, Singh +5 more
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Preparation and Solidification of Redispersible Nanosuspensions
Journal of Pharmaceutical Sciences, 2014To test the feasibility of preparing redispersible powders from nanosuspensions without further addition of drying protectants, Lovastatin was processed into nanosuspensions and subsequently converted into a powder form using a spray-drying process.
Xin, Zhang +4 more
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A mini review of nanosuspensions development
Journal of Drug Targeting, 2011Nanosuspension drug delivery has obtained great success in the preparation of insoluble drugs. The nanosuspension technology can confer a series of special characteristics to the drugs, such as the enhanced dissolution rate and saturation solubility. This mini review first described the differences between the nanocrystals and nanosuspensions.
Yue, Liu +3 more
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Nanosuspensions of hesperetin: preparation and characterization
Die Pharmazie, 2014Nanosuspensions are a smart formulation principle for dermal applications, as they increase the penetration of poorly soluble substances into the skin. Because microbial stability is a pre-requisite for dermal formulations, water containing formulations need to be preserved.
L, Al Shaal +3 more
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Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats
Die Pharmazie, 2011The purpose of the present study was to investigate the pharmacokinetics of hydroxycamptothecin nanosuspensions after intravenous administration in rats. Hydroxycamptothecin injection was studied parallelly. The results showed that AUC0→∞, MRT, t1/2(α) and t1/2(β) of hydroxycamptothecin nanosuspensions was significantly higher, while their total body ...
Lei, Wang +4 more
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Safety of nanosuspensions in drug delivery
Nanomedicine: Nanotechnology, Biology and Medicine, 2017Nanosuspension technology is currently undergoing dramatic expansion in pharmaceutical science research and development. However, most of the research efforts generally focus on formulation and potential beneficial description, while the research into potential toxicological effects and implications (i.e., in vivo safety and health effects) is lacking.
Lulu Wang +3 more
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Nanosuspensions in drug delivery
Nature Reviews Drug Discovery, 2004A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions.
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Waveguides in colloidal nanosuspensions
SPIE Proceedings, 2014We present and discuss a set of experiments based on the application of the nonlinear properties of colloidal nanosuspensions to induce waveguides with a high‐power CW laser beam (wavelength 532nm) and its use for controlling an additional probe beam.
Luis A. López-Peña +5 more
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On the effective viscosity of nanosuspensions
Technical Physics, 2009The effective viscosity of nanosuspensions is simulated using the molecular dynamics method. It is found that viscosity is controlled not only by the volume concentration of nanoparticles, by also by their mass and diameter. The viscosity of even strongly rarefied nanosuspensions (with a low concentration of nanoparticles) cannot be described by the ...
V. Ya. Rudyak +2 more
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