Results 171 to 180 of about 4,959 (213)
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Nanosuspensions in drug delivery
Nature Reviews Drug Discovery, 2004A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions.
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A mini review of nanosuspensions development
Journal of Drug Targeting, 2011Nanosuspension drug delivery has obtained great success in the preparation of insoluble drugs. The nanosuspension technology can confer a series of special characteristics to the drugs, such as the enhanced dissolution rate and saturation solubility. This mini review first described the differences between the nanocrystals and nanosuspensions.
Yue, Liu +3 more
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Waveguides in colloidal nanosuspensions
SPIE Proceedings, 2014We present and discuss a set of experiments based on the application of the nonlinear properties of colloidal nanosuspensions to induce waveguides with a high‐power CW laser beam (wavelength 532nm) and its use for controlling an additional probe beam.
Luis A. López-Peña +5 more
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On the effective viscosity of nanosuspensions
Technical Physics, 2009The effective viscosity of nanosuspensions is simulated using the molecular dynamics method. It is found that viscosity is controlled not only by the volume concentration of nanoparticles, by also by their mass and diameter. The viscosity of even strongly rarefied nanosuspensions (with a low concentration of nanoparticles) cannot be described by the ...
V. Ya. Rudyak +2 more
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2006
A more reliable laser diffractometer analytical procedure was developed to assess with higher accuracy the size of nanocrystals, the prerequisite for a sound formulation development. The screening procedure for optimised nanosuspension formulations was distinctly improved and the mechanism, leading to artefacts in the previous procedures, could be ...
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A more reliable laser diffractometer analytical procedure was developed to assess with higher accuracy the size of nanocrystals, the prerequisite for a sound formulation development. The screening procedure for optimised nanosuspension formulations was distinctly improved and the mechanism, leading to artefacts in the previous procedures, could be ...
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Colloids and Surfaces B: Biointerfaces, 2016
The exploration of a simple and robust approach to produce nanosuspensions is a meaningful attempt for clinical translation. CO2-assisted effervescence was firstly developed to prepare nanosuspensions and was found to be easy for scale-up. Drug nanosuspensions were easily obtained by adding aqueous carbonate to the pre-treated mixture of drug ...
Xiangfei, Han +4 more
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The exploration of a simple and robust approach to produce nanosuspensions is a meaningful attempt for clinical translation. CO2-assisted effervescence was firstly developed to prepare nanosuspensions and was found to be easy for scale-up. Drug nanosuspensions were easily obtained by adding aqueous carbonate to the pre-treated mixture of drug ...
Xiangfei, Han +4 more
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Mechanism of freeze-drying drug nanosuspensions
International Journal of Pharmaceutics, 2012Drug nanoparticles prepared in a liquid medium are commonly freeze-dried for the preparation of an oral dosage in solid dosage form. The freezing rate is known to be a critical parameter for redispersible nanoformulations. However, there has been controversy as to whether a fast or slow freezing rate prevents irreversible aggregation.
Nae-Oh, Chung +2 more
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Amorphous isradipine nanosuspension by the sonoprecipitation method
International Journal of Pharmaceutics, 2014The aims of this study are to increase and explain the mechanism of dissolution enhancement of isradipine using the sonoprecipitation method for stable nanosuspensions. There have been still few of published researches on formulation of isradipine using nanoparticle engineering.
Thao Truong-Dinh, Tran +6 more
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Preparation and cytotoxic activity of hydroxycamptothecin nanosuspensions
International Journal of Pharmaceutics, 2010Hydroxycamptothecin is a promising anticancer agent that possesses the ability to inhibit the growth of a wide range of human tumors. Owing to its poor solubility and instability, the pharmaceutical development and clinical utilization of hydroxycamptothecin have been limited.
Yong-Xing, Zhao +5 more
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Recent Survey on Nanosuspension: A Patent Overview
Recent Patents on Drug Delivery & Formulation, 2015The major goals of designing nanosuspension of nanosize materials are increasing due to their tremendous potential as a drug delivery system with the wide range of applications. Nanosuspension is a unique tool for improving the bioavailability of poorly soluble drugs.
Sahilhusen I, Jethara +4 more
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