Results 181 to 190 of about 7,736 (212)

NANOSUSPENSION

2022
Authors : Prof.
Prof. ANUPAMA DIWAN, SHEKHAR SHARMA
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Formulation aspects of intravenous nanosuspensions

International Journal of Pharmaceutics, 2020
Intravenous (IV) route is preferred for rapid onset of action, avoiding first pass metabolism and achieving site specific delivery. Development of IV formulations for poorly water soluble drugs poses significant challenges. Formulation approaches like salt formation, co-solvents, surfactants and inclusion complexation using cyclodextrins are used for ...
Dipeekakumari, Patel, Sandeep S, Zode, Arvind K, Bansal   +2 more
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Paclitaxel nanosuspensions for targeted chemotherapy – nanosuspension preparation, characterization, and use

Pharmaceutical Development and Technology, 2013
The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic. Different particle coatings were employed to assess their impact on cellular uptake in vitro. In vivo work was then performed to demonstrate efficacy in tumor-bearing mouse models.Paclitaxel nanosuspensions were ...
Sarah E, Lee, Shawn F, Bairstow, Jane O, Werling, Mahesh V, Chaubal, Lawrence, Lin, Mary Ann, Murphy, James P, DiOrio, Jerome, Gass, Barrett, Rabinow, Xiaoen, Wang, Yong, Zhang, Zhijian, Yang, Robert M, Hoffman   +12 more
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Nanosuspension: Principles, Perspectives and Practices

Current Drug Delivery, 2016
In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose.
Sachin Kumar, Singh, Yogyata, Vaidya, Monica, Gulati, Sibasis, Bhattacharya, Varun, Garg, Narendra Kumar, Pandey   +5 more
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Waveguides in colloidal nanosuspensions

SPIE Proceedings, 2014
We present and discuss a set of experiments based on the application of the nonlinear properties of colloidal nanosuspensions to induce waveguides with a high‐power CW laser beam (wavelength 532nm) and its use for controlling an additional probe beam.
Luis A. López-Peña, Yadira Salazar-Romero, Roland A. Terborg, Juan Hernández-Cordero, Juan P. Torres, K. Volke-Sepúlveda   +5 more
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Optical beam instabilities in nonlinear nanosuspensions

Optics Letters, 2007
We investigate the modulation instability of plane waves and the transverse instabilities of soliton stripe beams propagating in nonlinear nanosuspensions. We show that in these systems the process of modulational instability depends on the input beam conditions.
El-Ganainy, R., Christodoulides, D. N., Musslimani, Ziad H., Rotschild, C., Segev, M.   +4 more
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Stability of nanosuspensions in drug delivery

Journal of Controlled Release, 2013
Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth.
Yancai Wang, Ying Zheng, Ling Zhang, Qiwei Wang, Dianrui Zhang   +4 more
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Nanosuspensions in drug delivery

Nature Reviews Drug Discovery, 2004
A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions.
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Mechanism of freeze-drying drug nanosuspensions

International Journal of Pharmaceutics, 2012
Drug nanoparticles prepared in a liquid medium are commonly freeze-dried for the preparation of an oral dosage in solid dosage form. The freezing rate is known to be a critical parameter for redispersible nanoformulations. However, there has been controversy as to whether a fast or slow freezing rate prevents irreversible aggregation.
Nae-Oh, Chung, Min Kyung, Lee, Jonghwi, Lee   +2 more
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A mini review of nanosuspensions development

Journal of Drug Targeting, 2011
Nanosuspension drug delivery has obtained great success in the preparation of insoluble drugs. The nanosuspension technology can confer a series of special characteristics to the drugs, such as the enhanced dissolution rate and saturation solubility. This mini review first described the differences between the nanocrystals and nanosuspensions.
Yue, Liu, Pengcheng, Xie, Dianrui, Zhang, Qiang, Zhang   +3 more
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