Results 151 to 160 of about 782 (172)

Maternal loss of 24-hydroxylase causes increased intestinal calcium absorption and hypercalcemia during pregnancy but reduced skeletal resorption during lactation in mice. [PDF]

J Bone Miner Res
Maekawa AS, Bennin D, Hartery SA, Kirby BJ, Poulton IJ, St-Arnaud R, Sims NA, Kovacs CS.   +7 more
europepmc   +1 more source

The Vedotin Antibody-Drug Conjugate Payload Drives Platform-Based Nonclinical Safety and Pharmacokinetic Profiles. [PDF]

Mol Cancer Ther
Neff-LaFord HD, Carratt SA, Carosino C, Everds N, Cardinal KA, Duniho S, Schutten MM, Frantz C, Zuch de Zafra C, Harstad EB.   +9 more
europepmc   +1 more source

Loss of 24-hydroxylated catabolism increases calcitriol and fibroblast growth factor 23 and alters calcium and phosphate metabolism in fetal mice. [PDF]

JBMR Plus
Bennin D, Hartery SA, Kirby BJ, Maekawa AS, St-Arnaud R, Kovacs CS.   +5 more
europepmc   +1 more source

The true cost of phosphate control in chronic kidney disease. [PDF]

Clin Kidney J
Rodelo-Haad C, Rodríguez-Ortiz ME, Garcia-Sáez R, Rivas-Domínguez A, Jurado-Montoya D, Martín-Malo A, Rodríguez M, Pendón-Ruiz de Mier MV, Muñoz-Castañeda JR.   +8 more
europepmc   +1 more source

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Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors

Bioorganic & Medicinal Chemistry Letters, 2022
We previously reported thiophene derivatives as gut-selective (minimally systemic) and potent sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors. However, these derivatives did not suppress phosphate absorption form the intestinal tract in Sprague-Dawley (SD) rats.
Yasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, Fumito Uneuchi, Yuta Asanuma, Chitose Yamaguchi, Hiroshi Ohta, Tsuyoshi Shibata, Tomohiro Abe, Lisa Okumura-Kitajima, Yuki Kosai, Mayumi Endo, Katsumasa Otake, Eiji Munetomo, Teisuke Takahashi, Hiroyuki Kakinuma   +15 more
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NaPi2b expression in a large surgical Non-Small Cell Lung Cancer (NSCLC) cohort

Clinical Lung Cancer, 2022
NaPi2b is a multi-transmembrane sodium-dependent phosphate transporter expressed at normal levels in several organs, including lung. High expression levels have been reported in various tumors including breast, thyroid, ovarian and non-small cell lung cancer.
S Heynemann, H Yu, L Churilov, G Rivalland, K Asadi, R Mosher, F Hirsch, C Rivard, P Mitchell   +8 more
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Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors

Bioorganic & Medicinal Chemistry, 2022
Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the lung and testis has been reported.In this article, we report on our identification of novel indole ...
Yasunobu, Ushiki, Kenichi, Kawabe, Kumiko, Yamamoto-Okada, Fumito, Uneuchi, Yuta, Asanuma, Chitose, Yamaguchi, Hiroshi, Ohta, Tsuyoshi, Shibata, Tomohiro, Abe, Lisa, Okumura-Kitajima, Yuki, Kosai, Mayumi, Endo, Katsumasa, Otake, Eiji, Munetomo, Teisuke, Takahashi, Hiroyuki, Kakinuma   +15 more
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Generation of Monoclonal Antibodies Against Tumor-Associated Antigen MX35/sodium-Dependent Phosphate Transporter NaPi2b

Hybridoma, 2011
Tumor-associated antigen MX35, which is overexpressed in 70-90% of epithelial ovarian cancers, has been recently identified as phosphate transporter NaPi2b. This finding has raised significant interest in understanding NaPi2b function under physiological conditions and its deregulation in human pathologies, such as cancer.
Ivan Gout, Valeriy Filonenko, Vitalina Gryshkova, L. O. Savinska, Dmytro Lituiev, Ramziya Kiyamova, Galina Ovcharenko   +6 more
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Development of Monoclonal Antibodies Specific for the Human Sodium-dependent Phosphate Co-transporter NaPi2b

Hybridoma, 2008
Homeostasis of inorganic phosphate in the human body is maintained by regulated absorption, metabolism, and excretion. Sodium-dependent phosphate transporters (NaPi) mediate the transport of inorganic phosphate (P(i)) in cells in response to dietary phosphate consumption, hormones, and growth factors.
Ivan Gout, Dmytro Lituyev, Sergyy Malyuchik, Vadym Gurtovyy, Galina Ovcharenko, Gerd Ritter, V. S. Usenko, Vitalina Gryshkova, Yuliya Khozhayenko, Valeriy Filonenko, Beatrice W.T. Yin, Lloyd Old, Ramziya Kiyamova   +12 more
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