Results 161 to 170 of about 820 (178)

Generation of Monoclonal Antibodies Against Tumor-Associated Antigen MX35/sodium-Dependent Phosphate Transporter NaPi2b

Hybridoma, 2011
Tumor-associated antigen MX35, which is overexpressed in 70-90% of epithelial ovarian cancers, has been recently identified as phosphate transporter NaPi2b. This finding has raised significant interest in understanding NaPi2b function under physiological conditions and its deregulation in human pathologies, such as cancer.
Vitalina, Gryshkova, Dmytro, Lituiev, Liliya, Savinska, Galina, Ovcharenko, Ivan, Gout, Valeriy, Filonenko, Ramziya, Kiyamova   +6 more
openaire   +2 more sources

RECOGNITION OF SODIUM-DEPENDENT PHOSPHATE TRANSPORTER NAPI2B BY MONOCLONAL ANTIBODIES IN BACTERIAL AND EUKARYOTIC CELLS

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2022
The membrane sodium-dependent phosphate transporter NaPi2b is attractive target for monoclonal antibody therapy. Recognition of the large extracellular domain (ECD) of NaPi2b by monoclonal antibodies L2(20/3) in Western blot analysis depends on the addition of DTT to lysates of eukaryotic cells, but not bacterial cells.
L.F. Bulatova, R.G. Kiyamova
openaire   +1 more source

Abstract 5085: Preclinical development of NaPi2b-PL2202, a novel camptothecin-based antibody-drug conjugate targeting solid tumors expressing NaPi2b

Cancer Research
Abstract NaPi2b, encoded by the SLC34A2 gene, is a multi-transmembrane, sodium-dependent phosphate transporter expressed at high levels in tumors and low levels in normal tissues. Functionally, it is involved in trans-cellular flux of phosphate in the small intestine and in the synthesis of surfactant in lung alveoli.
Elizabeth Horsley, Asma Jabeen, Nicolas Veillard, Karin Havenith, Narinder Janghra, Pedro Alves, Cecile Oblette, Ian Kirby, Paul W. Hogg, Francesca Zammarchi, Lolke de Haan, Patrick van Berkel   +11 more
openaire   +1 more source

Development of Monoclonal Antibodies Specific for the Human Sodium-dependent Phosphate Co-transporter NaPi2b

Hybridoma, 2008
Homeostasis of inorganic phosphate in the human body is maintained by regulated absorption, metabolism, and excretion. Sodium-dependent phosphate transporters (NaPi) mediate the transport of inorganic phosphate (P(i)) in cells in response to dietary phosphate consumption, hormones, and growth factors.
Ramziya, Kiyamova, Vitalina, Gryshkova, Galina, Ovcharenko, Dmytro, Lituyev, Sergyy, Malyuchik, Vasiliy, Usenko, Yuliya, Khozhayenko, Vadym, Gurtovyy, Beatrice, Yin, Gerd, Ritter, Lloyd, Old, Valeriy, Filonenko, Ivan, Gout   +12 more
openaire   +2 more sources

Abstract 1533: ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload

Cancer Research, 2023
Abstract Background: NaPi2b is a multi-pass transmembrane sodium-dependent phosphate transport protein encoded by the gene SLC34A2. NaPi2b is involved in normal phosphate homeostasis and its expression is found in the lung, liver, and small intestine.
Andrea Hernandez Rojas, Jodi Wong, Dunja Urosev, Sam Lawn, Kaylee Wu, Saki Konomura, Manuel Lasalle, Diego A. Alonzo, Luying Yang, Mark Petersen, Lemlem T. Degefie, Araba P. Sagoe-Wagner, Sohyeong Kang, Chi Wing Cheng, Raffaele Colombo, Daya Siddappa, Stuart D. Barnscher, Jamie R. Rich   +17 more
openaire   +1 more source

Abstract A043: NaPi2b expression in a large surgical non-small cell lung cancer cohort

Molecular Cancer Therapeutics, 2019
Abstract Background: NaPi2b (SLC34A2) is a sodium-dependent phosphate transporter expressed in a high proportion of non-small cell lung cancer (NSCLC), especially adenocarcinoma, and ovarian carcinoma cases, as well as other tumour types.
Paul L Mitchell, Hui Yu, Gareth Rivalland, Khashayar Asadi, Rebecca Mosher, Fred Hirsch, Christopher Rivard   +6 more
openaire   +1 more source

In Silico Analysis and Immunohistochemical Characterization of NaPi2b Protein Expression in Ovarian Carcinoma With Monoclonal Antibody Mx35

Applied Immunohistochemistry & Molecular Morphology, 2012
Ovarian adenocarcinoma is frequently detected at the late stage, when therapy efficacy is limited and death occurs in up to 50% of the cases. A potential novel treatment for this disease is a monoclonal antibody that recognizes phosphate transporter sodium-dependent phosphate transporter protein 2b (NaPi2b).To better understand the expression of this ...
Soares, Ibere Cauduro, Simoes, Kleber, Santana de Souza, Jorge Estefano, Okamoto, Oswaldo Keith UNIFESP, Wakamatsu, Alda, Tuma, Maria Carolina, Ritter, Gerd, Ferreira Alves, Venancio Avancini   +7 more
openaire   +3 more sources

Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas.

Cancer immunity, 2008
Mouse monoclonal antibody MX35 was developed against ovarian cancer. The antibody showed homogeneous reactivity with approximately 90% of human ovarian epithelial cancers and with a limited number of normal tissues by immunohistochemistry. Although mAb MX35 has been used in a number of clinical trials in ovarian cancer, it has been difficult to define ...
Beatrice W T, Yin, Ramziya, Kiyamova, Ramon, Chua, Otavia L, Caballero, Ivan, Gout, Vitalina, Gryshkova, Nimesh, Bhaskaran, Serhiy, Souchelnytskyi, Ulf, Hellman, Valeriy, Filonenko, Achim A, Jungbluth, Kunle, Odunsi, Kenneth O, Lloyd, Lloyd J, Old, Gerd, Ritter   +14 more
openaire   +1 more source

Abstract 5907: Pre-clinical evaluation of a novel antibody drug conjugate (ADC) LM-317 targeting NaPi2b

Cancer Research
Abstract Introduction: NaPi2b is a multi-transmembrane type II sodium-dependent phosphate transporters that regulates phosphate homeostasis in normal physiological condition [1]. It is highly expressed in ovarian cancer (OC), non-small-cell lung cancer (NSCLC), and papillary thyroid cancer, with limited expression in normal tissue ...
Wentao Huang, Zhifang Liu, Yifan Li, Heng Pan, Xia Qin, Da Fei, Runsheng Li   +6 more
openaire   +1 more source

Abstract LB138: A novel dual-TOP1i ADC targeting NaPi2b designed for high efficacy and tolerability

Cancer Research
Abstract The Araris site-specific and one-step linker conjugation technology aims at generating stable, safe and highly potent ADCs without the need for antibody engineering prior to payload conjugation. Here we show data on a novel, multi-warhead anti-NaPi2b ADC armed with two different Topoisomerase-1 inhibitors (TOP1i) as payloads ...
Isabella Attinger-Toller, Philipp Probst, Romain Bertrand, Emma Renard, Lia Kallenberger, Ramona Stark, Patrick Maurhofer, Dragan Grabulovski, Bernd Schlereth, Philipp R. Spycher   +9 more
openaire   +1 more source