Results 161 to 170 of about 782 (172)
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Abstract A043: NaPi2b expression in a large surgical non-small cell lung cancer cohort
Molecular Cancer Therapeutics, 2019Abstract Background: NaPi2b (SLC34A2) is a sodium-dependent phosphate transporter expressed in a high proportion of non-small cell lung cancer (NSCLC), especially adenocarcinoma, and ovarian carcinoma cases, as well as other tumour types.
Christopher J. Rivard +6 more
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Cancer Research
Abstract NaPi2b, encoded by the SLC34A2 gene, is a multi-transmembrane, sodium-dependent phosphate transporter expressed at high levels in tumors and low levels in normal tissues. Functionally, it is involved in trans-cellular flux of phosphate in the small intestine and in the synthesis of surfactant in lung alveoli.
Elizabeth Horsley +11 more
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Abstract NaPi2b, encoded by the SLC34A2 gene, is a multi-transmembrane, sodium-dependent phosphate transporter expressed at high levels in tumors and low levels in normal tissues. Functionally, it is involved in trans-cellular flux of phosphate in the small intestine and in the synthesis of surfactant in lung alveoli.
Elizabeth Horsley +11 more
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Applied Immunohistochemistry & Molecular Morphology, 2012
Ovarian adenocarcinoma is frequently detected at the late stage, when therapy efficacy is limited and death occurs in up to 50% of the cases. A potential novel treatment for this disease is a monoclonal antibody that recognizes phosphate transporter sodium-dependent phosphate transporter protein 2b (NaPi2b).To better understand the expression of this ...
Soares, Ibere Cauduro +7 more
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Ovarian adenocarcinoma is frequently detected at the late stage, when therapy efficacy is limited and death occurs in up to 50% of the cases. A potential novel treatment for this disease is a monoclonal antibody that recognizes phosphate transporter sodium-dependent phosphate transporter protein 2b (NaPi2b).To better understand the expression of this ...
Soares, Ibere Cauduro +7 more
openaire +4 more sources
Correlating expression of NaPi2b and FRa in high grade serous ovarian cancer (HGSOC).
Journal of Clinical Oncology, 20235545 Background: Biomarker driven therapies are increasingly being used for gynecologic cancers, with mirvetuximab soravtansine, a Folate Receptor alpha (FRa) targeting antibody drug conjugate (ADC) being a recent FDA approved agent for patients with FRa positive PROC. Uptifitamab rilsodotin (UpRi) is a late-stage, first in class NaPi2b-targeting ADC
Debra L. Richardson +14 more
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BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2022
The membrane sodium-dependent phosphate transporter NaPi2b is attractive target for monoclonal antibody therapy. Recognition of the large extracellular domain (ECD) of NaPi2b by monoclonal antibodies L2(20/3) in Western blot analysis depends on the addition of DTT to lysates of eukaryotic cells, but not bacterial cells.
L.F. Bulatova, R.G. Kiyamova
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The membrane sodium-dependent phosphate transporter NaPi2b is attractive target for monoclonal antibody therapy. Recognition of the large extracellular domain (ECD) of NaPi2b by monoclonal antibodies L2(20/3) in Western blot analysis depends on the addition of DTT to lysates of eukaryotic cells, but not bacterial cells.
L.F. Bulatova, R.G. Kiyamova
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XI Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов, молекулярных биологов и специалистов фундаментальной медицины — 2024 : сб. тез.
In this work, by chemical modification of mutant variants of the NaPi2b transporter with maleimide-containing compounds, we determined the positions of disulfide bonds in the largest extracellular domain, that maintain its conformation necessary for recognition of the MX35 epitope by monoclonal antibodies.
A.V. Kilunov +5 more
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In this work, by chemical modification of mutant variants of the NaPi2b transporter with maleimide-containing compounds, we determined the positions of disulfide bonds in the largest extracellular domain, that maintain its conformation necessary for recognition of the MX35 epitope by monoclonal antibodies.
A.V. Kilunov +5 more
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Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas.
Cancer immunity, 2008Mouse monoclonal antibody MX35 was developed against ovarian cancer. The antibody showed homogeneous reactivity with approximately 90% of human ovarian epithelial cancers and with a limited number of normal tissues by immunohistochemistry. Although mAb MX35 has been used in a number of clinical trials in ovarian cancer, it has been difficult to define ...
Beatrice W T, Yin +14 more
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Cancer Research
Abstract SLC34A2 is overexpressed in 61% of ovarian cancer and 18% of uterine cancer tumors. SLC34A2 overexpression is believed to be driven by the aberrant activity of the essential PAX8 transcription factor in these tumors. Overexpression of SLC34A2, a phosphate importer, sensitizes the cells to the genetic depletion of XPR1, the sole ...
Mansi Babbar +24 more
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Abstract SLC34A2 is overexpressed in 61% of ovarian cancer and 18% of uterine cancer tumors. SLC34A2 overexpression is believed to be driven by the aberrant activity of the essential PAX8 transcription factor in these tumors. Overexpression of SLC34A2, a phosphate importer, sensitizes the cells to the genetic depletion of XPR1, the sole ...
Mansi Babbar +24 more
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Abstract LB138: A novel dual-TOP1i ADC targeting NaPi2b designed for high efficacy and tolerability
Cancer ResearchAbstract The Araris site-specific and one-step linker conjugation technology aims at generating stable, safe and highly potent ADCs without the need for antibody engineering prior to payload conjugation. Here we show data on a novel, multi-warhead anti-NaPi2b ADC armed with two different Topoisomerase-1 inhibitors (TOP1i) as payloads ...
Isabella Attinger-Toller +9 more
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