Results 171 to 178 of about 820 (178)

Abstract 2976: XPR1 and SLC34A2 (NaPi2B)- A tale of targeting the phosphate homeostasis in cancer cells

Cancer Research
Abstract SLC34A2 is overexpressed in 61% of ovarian cancer and 18% of uterine cancer tumors. SLC34A2 overexpression is believed to be driven by the aberrant activity of the essential PAX8 transcription factor in these tumors. Overexpression of SLC34A2, a phosphate importer, sensitizes the cells to the genetic depletion of XPR1, the sole ...
Mansi Babbar, Dion Daniels, Katie Vowell, Rajesh Sundaresan, Shuzhen Wu, Feng Wang, James Lin, Jenny Laraio, Justin Munro, Joseph Kozole, John Kreeger, Geeta Sharma, Bryan Joosse, Florence Patel, Joseph Tomlinson, Katherine Welbeck, Richard Priest, Jennifer Percival-Alwyn, Trevor Wattam, Gurjinder Heer, Iain Moal, Sreenivas Nannapaneni, Benjamin Schwartz, Biju Mangatt, Anthony Mazurek   +24 more
openaire   +1 more source

NaPi2b diffusion and activity could be regulated by membrane fluidity in the microvilli of the small intestine

The FASEB Journal, 2016
Inorganic phosphate (Pi) plays an important role in growth, development, bone formation and cellular metabolism. A physiological phosphate balance is maintained through the multi‐organ communication among intestine, kidneys and bones.
Saif I. Al‐Juboori, Tim Lei, Veronica Hogg‐Cornejo, Eileen Sutherland, Moshe Levi, Evgenia Dobrinskikh   +5 more
openaire   +1 more source

Abstract 1563: ADRX-0134 as a novel auristatin-based NaPi2b antibody-drug conjugate with widened therapeutic window

Cancer Research
Abstract Sodium-dependent phosphate transport protein 2B (NaPi2b; SLC34A2) is overexpressed in a variety of cancers, including lung carcinomas, ovarian, and endometrial cancers with restricted normal tissue expression. Based on this differential expression profile, a proof-of-concept for an antibody-drug conjugate (ADC) approach ...
Andrew M. Hau, Kris Zhang, Maria Shahmoradgoli, Mario M.-C. Kuo, Dong Jun Lee, Anna Y. Wang, Peter P. Challita, Oscar Betancourt, Wes Sisson, Erin Nye, Monica Leung, Albert Goldson, Felipe Acosta, Alexander Chu-Kung, Hui Li, Sabine Rottmann, Pia M. Challita-Eid   +16 more
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Распознавание Na-зависимого фосфатного транспортера NaPi2b моноклональными антителами в клетках бактерий и эукариот

Biotekhnologiya, 2022
openaire   +1 more source

53P Expression of sodium-dependent phosphate transporter NaPi2b is downregulated in malignant ovarian tumors after neoadjuvant chemotherapy

Annals of Oncology, 2021
A.K. Nurgalieva, S. Safina, E. Shakirova, V. Filonenko, V. Skripova, L. Bulatova, D. Savenkova, M. Bogdanov, R. Kiyamova   +8 more
openaire   +1 more source

171 (PB159): Preclinical characterization of NaPi2b-PL2202, a novel exatecan-based antibody drug conjugate

European Journal of Cancer
A. Jabeen, N. Janghra, E. Horsley, C. Gallagher, C. Oblette, A. Kamenski, P.H van Berkel   +6 more
openaire   +1 more source

Effect of Anti-NaPi2b Monoclonal Antibody on Phosphate Transport in Renal Cancer Cell Line SK-RC-18

International Journal of Physiology and Pathophysiology, 2011
Ramziya G. Kiyamova, Ganna A. Savchenko, Vitalina S. Gryshkova, Galina V. Ovcharenko, Yaroslav A. Boychuk, Oleg O. Krishtal, Valeriy V. Filonenko   +6 more
openaire   +1 more source

An Isolation and Functional Properties Of N-Terminus Of Human Napi2b By  Scalable “Resin Overload” Technique

Daria Savenkova, Irina Makarenko, Daria Nedorezova, Ramziya Kiyamova, Mikhail Bogdanov   +4 more
openaire   +1 more source