Results 11 to 20 of about 820 (178)

PBPK Modeling to Predict Clinical Drug–Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F‐Hydroxypropylamide [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Upifitamab rilsodotin—an antibody drug conjugate (ADC)—comprises a NaPi2b‐targeted antibody conjugated to an auristatin‐based payload (auristatin F‐hydroxypropylamide [AF‐HPA]). AF‐HPA is metabolized by cytochrome P450 3A4 (CYP3A4) and, to a lower extent,
Niyanta Kumar, Vaishali Dixit, Howard Burt, Katherine L. Gill, Hannah M. Jones, Natalie Keirstead, Dian Su, Dorin Toader, Timothy B. Lowinger   +8 more
doaj   +3 more sources

Development of an in vitro model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ovarian carcinoma cells [PDF]

Успехи молекулярной онкологии
Introduction. The sodium-dependent phosphate transporter NaPi2b is a promising target for targeted antitumor therapy. There is the largest extracellular domain (ECD) containing a cryptic MX35 epitope, against which therapeutic antibodies have been ...
V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova   +5 more
doaj   +4 more sources

Sodium-dependent phosphate transporter NaPi2b as a candidate for targeted therapy: features of structure, function, and expression [PDF]

Успехи молекулярной онкологии
The sodium-dependent phosphate transporter NaPi2b is an integral membrane protein of the SLC34 phosphate transporter family and is an attractive target for precision therapy of several human diseases.
R. G. Kiyamova, R. A. Vlasenkova, L. F. Bulatova   +2 more
doaj   +4 more sources

Hyperphosphatemia in Chronic Kidney Disease: The Search for New Treatment Paradigms and the Role of Tenapanor [PDF]

International Journal of Nephrology and Renovascular Disease
Valeria Cernaro, Elisa Longhitano, Chiara Casuscelli, Luigi Peritore, Domenico Santoro Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyCorrespondence: Domenico Santoro, Unit of ...
Cernaro V, Longhitano E, Casuscelli C, Peritore L, Santoro D   +4 more
doaj   +5 more sources

Inhibition of sodium-dependent phosphate transporter NaPi2b function with MX35 antibody [PDF]

Biopolymers and Cell, 2011
????????????-???????????????? ?????????????????????? ?????????????? NaPi2b ???????? ???????????? ?? ?????????????????????? ?????????????????????????? ?????????????? ???? ?????????????????????? ???????????????????? ???????????????????? ?? ?????????????????? ????????????. ?????????????????? NaPi2b ?????????????? ???? ???????????? ???????? ?????????????? ?
Gryshkova, V.S., Filonenko, V.V., Kiyamova, R.G.   +2 more
openaire   +4 more sources

Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species [PDF]

mAbs, 2022
Biotherapeutics are exposed to common transition metal ions such as Cu(II) and Fe(II) during manufacturing processes and storage. IgG1 biotherapeutics are vulnerable to reactive oxygen species (ROS) generated via metal-catalyzed oxidation reactions ...
Zephania Kwong Glover, Aaron Wecksler, Baikuntha Aryal, Shrenik Mehta, Melissa Pegues, Wayman Chan, Mari Lehtimaki, Allen Luo, Alavattam Sreedhara, V. Ashutosh Rao   +9 more
doaj   +2 more sources

Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version Rebmab200. [PDF]

PLoS ONE, 2015
The aim of this preclinical study was to evaluate the characteristics of the monoclonal antibody Rebmab200, which is a humanized version of the ovarian-specific murine antibody MX35.
Sture Lindegren, Luciana N S Andrade, Tom Bäck, Camila Maria L Machado, Bruno Brasil Horta, Carlos Buchpiguel, Ana Maria Moro, Oswaldo Keith Okamoto, Lars Jacobsson, Elin Cederkrantz, Kohshin Washiyama, Emma Aneheim, Stig Palm, Holger Jensen, Maria Carolina B Tuma, Roger Chammas, Ragnar Hultborn, Per Albertsson   +17 more
doaj   +3 more sources

ADC: a deadly killer of platinum resistant ovarian cancer [PDF]

Journal of Ovarian Research
Platinum is a key component of ovarian cancer systemic therapy. However, most patients will eventually face a recurrence, leading to chemotherapy resistance, especially against platinum.
Xu Cheng, Ping Li, Rongqi Jiang, Enqing Meng, Hao Wu   +4 more
doaj   +2 more sources

Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.

PLoS ONE, 2013
NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials but ...
Mariana Lopes dos Santos, Fernanda Perez Yeda, Lilian Rumi Tsuruta, Bruno Brasil Horta, Alécio A Pimenta, Theri Leica Degaki, Ibere C Soares, Maria Carolina Tuma, Oswaldo Keith Okamoto, Venancio A F Alves, Lloyd J Old, Gerd Ritter, Ana Maria Moro   +12 more
doaj   +3 more sources

Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation

Annals of Oncology, 2019
Abstract Background Searching for specific targets in cancer diagnosis and treatment is one of the most important problems in clinical oncology. We put forward a new concept of the emergence of tumor-specific epitopes of integral membrane proteins by changing their topology under mutations, glycosylation and tumor conditions including low pH and ...
L. Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova   +6 more
openaire   +2 more sources