Results 21 to 30 of about 820 (178)

Uncovering potential targets for antibody-drug conjugates in the treatment of gynecologic malignancies [PDF]

Frontiers in Pharmacology
BackgroundAntibody-drug conjugates (ADCs) play an important role in the targeted therapy of gynecological malignancies. The purpose of this study was to investigate the expression of targets in gynecologic malignancies in order to predict the selection ...
Yuying Jiang, Yuance Xu, Junqi He, Lei Sui, Tian Li, Nannan Xia, Qin Yao   +6 more
doaj   +2 more sources

Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors

Bioorganic & Medicinal Chemistry, 2022
Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the lung and testis has been reported.In this article, we report on our identification of novel indole ...
Yasunobu, Ushiki, Kenichi, Kawabe, Kumiko, Yamamoto-Okada, Fumito, Uneuchi, Yuta, Asanuma, Chitose, Yamaguchi, Hiroshi, Ohta, Tsuyoshi, Shibata, Tomohiro, Abe, Lisa, Okumura-Kitajima, Yuki, Kosai, Mayumi, Endo, Katsumasa, Otake, Eiji, Munetomo, Teisuke, Takahashi, Hiroyuki, Kakinuma   +15 more
openaire   +3 more sources

Data from The Dolaflexin-based Antibody–Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b

, 2023
<div>Abstract<p>Target selection for antibody–drug conjugates (ADC) frequently focuses on identifying antigens with differential expression in tumor and normal tissue, to mitigate the risk of on-target toxicity. However, this strategy restricts the possible target space.
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak   +23 more
openaire   +2 more sources

Translational Pkpd of Dnib0600A, an Anti-Napi2B-Vc-Mmae Adc in Ovarian and Nsclc Cancers [PDF]

Annals of Oncology, 2014
This study investigated the safety and tolerability of lifastuzumab vedotin (DNIB0600A) (LIFA), an antibody-drug conjugate, in patients with recurrent platinum-sensitive ovarian cancer (PSOC).In this open-label, multicenter phase 1b study, LIFA was administered intravenously once every 3 weeks (Q3W) with starting dose 1.2 mg/kg in a 3 + 3 dose ...
K. Lin, S. Sukumaran, J. Xu, C. Zhang, Y. Choi, S. Yu, P. Polakis, D. Maslyar   +7 more
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Immunomodulatory Protective Effects of Rb9 Cyclic-Peptide in a Metastatic Melanoma Setting and the Involvement of Dendritic Cells [PDF]

Frontiers in Immunology, 2020
The cyclic VHCDR3-derived peptide (Rb9) from RebMab200 antibody, directed to a NaPi2B phosphate-transport protein, displayed anti-metastatic melanoma activity at 50–300 μg intraperitoneally injected in syngeneic mice.
Fabrício C. Machado, Fabrício C. Machado, Natália Girola, Natália Girola, Vera S. C. Maia, Vera S. C. Maia, Patrícia C. Bergami-Santos, Patrícia C. Bergami-Santos, Alice S. Morais, Ricardo A. Azevedo, Carlos R. Figueiredo, Carlos R. Figueiredo, José A. M. Barbuto, José A. M. Barbuto, Luiz R. Travassos, Luiz R. Travassos   +15 more
doaj   +3 more sources

3P NaPi2b expression in high grade serous ovarian cancer: Results from combined data sets [PDF]

ESMO Open, 2023
S. Banerjee, D.L. Richardson, N. Concin, B.J. Monk, M.R. Mirza, R.L. Coleman, I.L. Ray-Coquard, B. Pothuri, C. Marth, L. Demars, C. Bradshaw, C. Dicristo, R. Mosher, R. Drapkin   +13 more
openaire   +2 more sources

IDENTIFICATION OF DISULFIDE BOND POSITIONS IN THE LARGEST EXTRACELLULAR DOMAIN OF THE SODIUM–DEPENDENT PHOSPHATE TRANSPORTER NAPI2B

XI Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов, молекулярных биологов и специалистов фундаментальной медицины — 2024 : сб. тез.
In this work, by chemical modification of mutant variants of the NaPi2b transporter with maleimide-containing compounds, we determined the positions of disulfide bonds in the largest extracellular domain, that maintain its conformation necessary for recognition of the MX35 epitope by monoclonal antibodies.
A.V. Kilunov, L.F. Bulatova, D.D. Reshetnikova, V.S. Skripova, R.G. Kiyamova, M.V. Bogdanov   +5 more
openaire   +2 more sources

EP014/#408 Evaluation of NAPI2B expression in a well annotated longitudinal tissue series of ovarian serous carcinomas [PDF]

E-Posters, 2022
Ronny Drapkin, Euihye Jung, Chelsea Bradshaw, Leslie Demars, Rebecca Mosher   +4 more
openaire   +2 more sources

Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2. [PDF]

Stem Cell Reports, 2022
Embryonic genome activation (EGA) is critical for embryonic development. However, our understanding of the regulatory mechanisms of human EGA is still incomplete.
Yoshihara M, Kirjanov I, Nykänen S, Sokka J, Weltner J, Lundin K, Gawriyski L, Jouhilahti EM, Varjosalo M, Tervaniemi MH, Otonkoski T, Trokovic R, Katayama S, Vuoristo S, Kere J.   +14 more
europepmc   +3 more sources

Construction of comprehensive amino acid networks from Molecular Dynamics trajectories and tumor mutational profile of human sodium transporter NaPi2b

The Thirteenth International Multiconference, 2022
R Vlasenkova
openaire   +2 more sources