Bioorganic & Medicinal Chemistry, 2022 Inhibition of intestinal sodium-dependent phosphate transport protein 2b (NaPi2b), responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia. Previously, we aimed to identify new drugs for hyperphosphatemia treatment and obtained zwitterionic ...
Michihiro Maemoto +8 more
openalex +4 more sources
Creation of cellular models for the analysis of sodium-dependent phosphate transporter NaPi2b, a potential marker for ovarian cancer [PDF]
Biopolymers and Cell, 2009 The aim of present study was to develop a model for a functional analysis of a recently identified marker of the ovarian cancer – sodium-dependent phosphate transporter NaPi2b. For this purpose, we have created HEK293 stable cell lines expressing wild type or mutant forms of NaPi2b (T330V substitution in a large extracellular loop and a 6 amino acid ...
Vitalina Gryshkova +3 more
openalex +5 more sources
Phosphate Frustration: Treatment Options to Complement Current Therapies. [PDF]
Int J Nephrol, 2022 Hyperphosphatemia eventually develops in almost all patients with advanced chronic kidney disease and is associated with negative clinical outcomes. Thus, guidelines recommend targeting treatment to normal phosphate levels in patients with chronic kidney disease.
Pergola PE.
europepmc +2 more sources
34P N-glycosylation status of membrane phosphate transporter NaPi2b is crucial for its epitope recognition by monoclonal antibody in tumour cells [PDF]
Annals of Oncology, 2020 Ramziya Kiyamova +7 more
openalex +3 more sources
Desenvolvimento de anticorpos anti-peptídeos sintéticos derivados da proteína transportadora de fosfato dependente de sódio NaPi2b. [PDF]
, 2014 Ângela Alice Amadeu Megale
openalex +3 more sources
Modeling of lung phenotype of Hermansky–Pudlak syndrome type I using patient-specific iPSCs [PDF]
, 2021 iPS細胞を用いてヘルマンスキー・パドラック症候群の肺病態の解析に成功 --研究が困難な遺伝性疾患の治療薬開発の足がかりに--. 京都大学プレスリリース. 2021-11-15.[Background] Somatic cells differentiated from patient-specific human induced pluripotent stem cells (iPSCs) could be a useful tool in human cell-based disease ...
Gotoh, Shimpei +7 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Genetic evidence of serum phosphate-independent functions of FGF-23 on bone [PDF]
, 2011 Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization.
Bergwitz, Clemens +7 more
core +5 more sources
Uncovering therapeutic opportunities in the clinical development of antibody‐drug conjugates
Clinical and Translational Medicine, Volume 13, Issue 9, September 2023., 2023 • Most ongoing Antibody‐drug conjugates (ADCs) have a classical structure, with a minority of them with specific formats • ADCs against TAAs of haematological malignancies are more specific than those for solid tumours. • Niche indications for ADCs included targets for CD71, PSMA, PTK7 or CD74, in breast, lung, stomach or colon cancer.
Cristina Nieto‐Jiménez +8 more
wiley +1 more source
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases
Biomolecules, 2021 The main goal of this study is to consider SLC34A2 as a potential prognostic marker of oncological diseases using the mutational, expression, and survival data of cancer studies which are publicly available online.
Ramilia Vlasenkova +4 more
doaj +1 more source