Results 31 to 40 of about 820 (178)
Proteomic Changes Associated With Endogenous FBXW7 Mutations in Moderately Differentiated Endometrial Cancer Cells Include Increased TROP2 and Galectin-3 Levels. [PDF]
Cancer MedABSTRACT Background Endometrial cancer (EC) is the fourth most commonly diagnosed cancer among women in the US and the fifth leading cause of cancer death in this population. The FBXW7 tumor suppressor gene is frequently mutated in all molecular subtypes of EC.
Urick ME +3 more
europepmc +2 more sources
Emerging role of mucins in antibody drug conjugates for ovarian cancer therapy. [PDF]
J Ovarian ResOvarian cancer stands as the deadliest gynecologic malignancy, responsible for nearly 65% of all gynecologic cancer-related deaths. The challenges in early detection and diagnosis, coupled with the widespread intraperitoneal spread of cancer cells and ...
Malik S +6 more
europepmc +3 more sources
Modeling of lung phenotype of Hermansky–Pudlak syndrome type I using patient-specific iPSCs [PDF]
, 2021 iPS細胞を用いてヘルマンスキー・パドラック症候群の肺病態の解析に成功 --研究が困難な遺伝性疾患の治療薬開発の足がかりに--. 京都大学プレスリリース. 2021-11-15.[Background] Somatic cells differentiated from patient-specific human induced pluripotent stem cells (iPSCs) could be a useful tool in human cell-based disease ...
Gotoh, Shimpei +7 more
core +1 more source
Genetic evidence of serum phosphate-independent functions of FGF-23 on bone [PDF]
, 2011 Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization.
Bergwitz, Clemens +7 more
core +5 more sources
Antibody Therapeutics for Epithelial Ovarian Cancer [PDF]
, 2022 INTRODUCTION: High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer.
An, Zhiqiang +3 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases
Biomolecules, 2021 The main goal of this study is to consider SLC34A2 as a potential prognostic marker of oncological diseases using the mutational, expression, and survival data of cancer studies which are publicly available online.
Ramilia Vlasenkova +4 more
doaj +1 more source
Uncovering therapeutic opportunities in the clinical development of antibody‐drug conjugates
Clinical and Translational Medicine, Volume 13, Issue 9, September 2023., 2023 • Most ongoing Antibody‐drug conjugates (ADCs) have a classical structure, with a minority of them with specific formats • ADCs against TAAs of haematological malignancies are more specific than those for solid tumours. • Niche indications for ADCs included targets for CD71, PSMA, PTK7 or CD74, in breast, lung, stomach or colon cancer.
Cristina Nieto‐Jiménez +8 more
wiley +1 more source
Microtubule‐targeting agents for cancer treatment: Seven binding sites and three strategies
MedComm – Oncology, Volume 2, Issue 3, September 2023., 2023 Microtubule‐targeting agents (MTAs) are pivotal in the field of cancer treatment. This study presents a comprehensive review of the seven binding sites and three strategies (stabilization, destabilization, and degradation) utilized by MTAs, along with an overview of their current clinical applications and challenges.
Xingyu Wang +3 more
wiley +1 more source
JBMR Plus, Volume 6, Issue 12, December 2022., 2022 Acute high dietary phosphorus following low‐phosphorus diet acclimation does not enhance intestinal fractional phosphorus absorption in nephrectomized male rats. ABSTRACT Dietary phosphorus restriction and phosphorus binders are commonly prescribed for patients with chronic kidney disease (CKD).
Kendal M Burstad +9 more
wiley +1 more source