Results 61 to 70 of about 820 (178)

Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder [PDF]

, 2023
Background: Inorganic phosphate (Pi) binders are the only pharmacologic treatment approved for hyperphosphatemia. However, Pi binders induce the expression of intestinal Pi transporters and have limited effects on the inhibition of Pi transport.
1316, 1430, 1574, 1579, 1584, 375089/profile-ja.html, 405934/profile-ja.html, 516, 60127/profile-ja.html, 60133/profile-ja.html, 60146/profile-ja.html, 70174208, 70325257, 71000064, 90304047, 90609687, Hayashi, Hisayoshi, Higashi, Ayami, Horiba, Naoshi, Ichida, Yasuhiro, Ishizuka, Noriko, Koike, Megumi, Komiya, Aoi, Miura, Mizuki, Miyamoto, Ken-ichi, Ohtomo, Shuichi, Segawa, Hiroko, Shimohata, Takaaki, Shiozaki, Yuji, Takahashi, Akira, Tanifuji, Kazuya, Uga, Minori, イシヅカ, ノリコ, イシヅカ, ノリコ, イチダ, ヤスヒロ, イチダ, ヤスヒロ, ウガ, ミノリ, ウガ, ミノリ, オオトモ, シュウイチ, オオトモ, シュウイチ, コイケ, メグミ, コミヤ, アオイ, コミヤ, アオイ, シオザキ, ユウヂ, シモハタ, タカアキ, セガワ, ヒロコ, タカハシ, アキラ, タニフジ, カズヤ, ハヤシ, ヒサヨシ, ハヤシ, ヒサヨシ, ヒガシ, アヤミ, ヒガシ, アヤミ, ホリバ, ナオシ, ホリバ, ナオシ, ミウラ, ミヅキ, ミウラ, ミヅキ, ミヤモト, ケンイチ, 下畑, 隆明, 塩﨑, 雄治, 宮本, 賢一, 小池, 萌, 瀬川, 博子, 谷藤, 和也, 髙橋, 章   +63 more
core  

The role of proline P325 residue in the recognition of the MX35 epitope of the sodium-dependent phosphate transporter NaPi2b by monoclonal antibodies in ovarian carcinoma cells

Успехи молекулярной онкологии
Introduction. One of the key components of cell membranes are membrane proteins, which provide a wide range of functions – from transport and signal transmission to coordination of intercellular interactions.
L. F. Bulatova, I. A. Slidzuk, A. V. Kilunov, V. S. Skripova, R. G. Kiyamova   +4 more
doaj   +1 more source

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

Modern approaches in suicidal gene therapy of malignant neoplasms

Успехи молекулярной онкологии
One of the promising directions in antitumor therapy is suicidal gene therapy based on the introduction of cytotoxic genes into tumor cells. Most often, these genes encode for enzymes of bacterial or viral origin, capable of direct or indirect killing of
E. V. Dudkina, V. V. Ulyanova, O. N. Ilinskaya   +2 more
doaj   +1 more source

Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.

PLoS ONE, 2015
Impaired mineral homeostasis and inflammation are hallmarks of chronic kidney disease (CKD), yet the underlying mechanisms of electrolyte regulation during CKD are still unclear.
Wilco P Pulskens, Melissa Verkaik, Fareeba Sheedfar, Ellen P van Loon, Bart van de Sluis, Mark G Vervloet, Joost G Hoenderop, René J Bindels, NIGRAM Consortium   +8 more
doaj   +1 more source

High expression of SLC34A2 is a favorable prognostic marker in lung adenocarcinoma patients

Tumor Biology, 2017
Dysregulation of SLC34A2 (NaPi2b) in tumors has attracted wide attention, but its expression and function in non–small cell lung cancer remains unclear.
Zhaoxuan Zhang, Shan Ye, Min Zhang, Jing Wu, Hong Yan, Xiaojie Li, Jie He   +6 more
doaj   +1 more source

The Efficacy and Safety of Folate Receptor α‐Targeted Antibody‐Drug Conjugate Therapy in Patients With High‐Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers: A Systematic Review and Meta‐Analysis

Cancer Medicine, Volume 13, Issue 21, November 2024.
ABSTRACT Background Antibody‐drug conjugates (ADC) have emerged as a highly promising systemic option in the treatment of recurrent ovarian cancer. The present study aimed to evaluate the treatment efficacy of folate receptor α (FRα)‐targeting ADCs, associated treatment‐related adverse events (TRAEs), and their impact on treatment safety.
Eun Taeg Kim, Ji Hyun Kim, Eun Young Park, In Hye Song, Han Song Park, Sang‐Yoon Park, Myong Cheol Lim   +6 more
wiley   +1 more source

Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants. [PDF]

iPS細胞から作った肺胞や気道の細胞によりSARS-CoV-2変異株の病原性を比較評価する. 京都大学プレスリリース. 2024-03-29.Micro-patterning a new system to induce alveolar and airway epithelial cells. 京都大学プレスリリース.
Gotoh, Shimpei, Hashimoto, Rina, Masui, Atsushi, Matsumura, Yasufumi, Nagao, Miki, Noda, Takeshi, Takayama, Kazuo, Yamamoto, Takuya   +7 more
core   +1 more source

Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies

MedComm, Volume 5, Issue 8, August 2024.
The antibodies of ADCs bind to antigens on the cell surface, forming ADC–antigen complexes. These complexes are subsequently internalized into lysosomes via receptor‐mediated endocytosis. Once inside the lysosomes, the ADCs can be degraded by enzymes or the acidic environment, releasing cytotoxic payloads that can disrupt DNA or inhibit microtubule ...
Jun He, Xianghua Zeng, Chunmei Wang, Enwen Wang, Yongsheng Li   +4 more
wiley   +1 more source

Development of antibody‐drug conjugates in cancer: Overview and prospects

Cancer Communications, Volume 44, Issue 1, Page 3-22, January 2024.
Abstract In recent years, remarkable breakthroughs have been reported on antibody‐drug conjugates (ADCs), with 15 ADCs successfully entering the market over the past decade. This substantial development has positioned ADCs as one of the fastest‐growing domains in the realm of anticancer drugs, demonstrating their efficacy in treating a wide array of ...
Dan‐Yun Ruan, Hao‐Xiang Wu, Qi Meng, Rui‐Hua Xu   +3 more
wiley   +1 more source