Results 71 to 80 of about 43,002 (287)

Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy

Epilepsia, EarlyView.
Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing, Lirong Han, Dongjun Guo, Thomas J. Foutz, Michael Wong   +4 more
wiley   +1 more source

Narcolepsy

JAAPA, 2021
ABSTRACT Narcolepsy continues to be a significantly underdiagnosed/misdiagnosed condition worldwide. According to the National Institutes of Health (NIH), an estimated 135,000 to 200,000 patients in the United States are living with narcolepsy.
openaire   +4 more sources

What does it mean to live with epilepsy? Burden of illness from the patient perspective

Epilepsia Open, EarlyView.
Our web based survey explored the real world experiences of patients with epilepsy (PwE) taking antiseizure medications (ASMs) who continue to have at least one seizure per month. The graphical abstract summarizes the study population, survey methodology, and key outcomes.
Joanne M. Wagner, Bhagyashree Oak, Brittany Smith, Amod Athavale, Jeffrey R. Skaar, Alvin Ong, Cynthia Harden   +6 more
wiley   +1 more source

Risk of immunotherapy-related narcolepsy in genetically predisposed patients: a case report of narcolepsy after administration of pembrolizumab

Journal for ImmunoTherapy of Cancer, 2020
Background Immune-related adverse events associated with immune checkpoint therapy cause autoimmune disease-like symptoms. People who carry specific genotypes or haplotypes of human leucocyte antigen (HLA) are known to be predisposed to develop ...
Shigehira Saji, Emi Tokuda, Takashi Kanbayashi, Yutaka Natori, Eisaku Sasaki, Shu Soeda, Shigenori Furukawa, Yusuke Azami   +7 more
doaj   +1 more source

Living with Narcolepsy: Current Management Strategies, Future Prospects, and Overlooked Real-Life Concerns

Nature and Science of Sleep, 2020
Narcolepsy is a neurological disorder of the sleep-wake cycle characterized by excessive daytime sleepiness (EDS), cataplexy, nighttime sleep disturbances, and REM-sleep-related phenomena (sleep paralysis, hallucinations) that intrude into wakefulness ...
Emily C. Barker, J. Flygare, S. Paruthi, K. Sharkey   +3 more
semanticscholar   +1 more source

Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature

Epilepsia Open, EarlyView.
Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat, I‐Chun Lee, Marica Rubino, Vehap Topçu, Melissa Chavez‐Castillo, Shao Ching Tu, Marwan Shinawi, Isabel Alfradique‐Dunham, Manouela Valtcheva, Astrid Adarmes‐Gómez, Daniel Macias‐Garcia, Laura Laura Muñoz‐Delgado, Silvia Jesús, Pablo Mir, Andreas Merkenschlager, Antonietta Coppola   +15 more
wiley   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

Nature Communications, 2019
Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support the hypothesis that NT1 is a T-cell-mediated autoimmune disease ...
N. W. Pedersen, A. Holm, N. Kristensen, Anne-Mette Bjerregaard, A. Bentzen, A. Marquard, Tripti Tamhane, K. Burgdorf, H. Ullum, P. Jennum, S. Knudsen, S. Hadrup, B. Kornum   +12 more
semanticscholar   +1 more source

A randomized trial of I‐SLEEP: A patient education and empowerment intervention on inpatient sleep duration and medical sleep disruptions

Journal of Hospital Medicine, EarlyView.
Abstract Background Sleep is essential for recovery in hospitalized patients, yet frequent disruptions from medical care make rest difficult. Most prior efforts have focused on environmental modifications, often overlooking patients' role in advocating for their sleep.
Aashna Sunderrajan, John Cursio, Noah Mason, Maxx Byron, Maylyn Martinez, Nicola Orlov, Kristen L. Knutson, Babak Mokhlesi, Valerie G. Press, David O. Meltzer, Vineet M. Arora   +10 more
wiley   +1 more source

Narcolepsy: an interface among neurology, immunology, sleep, and genetics

Arquivos de Neuro-Psiquiatria
Narcolepsy is a primary disorder of the central nervous system resulting from genetic, environmental, and immunological interactions defined as excessive daytime sleepiness plus cataplexy, hallucinations, sleep paralysis, and sleep fragmentation.
Fernando Morgadinho Santos Coelho
doaj   +1 more source