Results 71 to 80 of about 20,829 (242)

Management of Insomnia Complaints by Non‐Sleep Specialist Physicians: A French DELPHI Consensus

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia is the most prevalent sleep disorder and a major public health concern, affecting chronically up to 19% of the adult population in France. Despite its significant impact on quality of life, mental health, and cardiometabolic disease, insomnia disorder remains underdiagnosed and inadequately managed.
Pierre‐Alexis Geoffroy, Jean‐Louis Pépin, Marjorie Guillet, Jean‐Bastien Micoulaud‐Franchi, Yves Dauvilliers, Damien Léger, Sylvie Royant‐Parola   +6 more
wiley   +1 more source

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Corticotropin‐Releasing Hormone (CRH) in Murine Narcolepsy: What Do Genetic and Immune Models Tell Us?

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type 1 is a chronic sleep disorder of putative autoimmune aetiology, primarily caused by the loss of orexin‐producing neurons in the hypothalamus. An additional 88% reduction in corticotropin‐releasing hormone‐immunoreactive neurons of the paraventricular nucleus has been recently observed in post‐mortem brains of individuals with ...
J. Zhou, S. Melzi, A. L. Morel, B. Georges, T. E. Scammell, G. J. Lammers, R. Fronczek, C. Peyron   +7 more
wiley   +1 more source

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years

Journal of Sleep Research, EarlyView.
ABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers   +4 more
wiley   +1 more source

Cyclic hypersomnolence with symptoms of narcolepsy with cataplexy: An unusual presentation of probable immune-mediated encephalitis

eNeurologicalSci, 2018
We report a case of probable encephalitis presenting as narcolepsy with cataplexy, but with cyclical exacerbation and cognitive difficulties. Our patient continued to worsen despite treatment for narcolepsy and later was thought to have an immune ...
Rafer Willenberg, Jonathan D. Bui
doaj   +1 more source

Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients

, 2022
Rebecca Evans, Haruhide Kimura, Robert Alexander, Ceri H. Davies, Hélène M. Faessel, Deborah Hartman, Takashi Ishikawa, Emiliangelo Ratti, Kohei Shimizu, Motohisa Suzuki, Shinichiro Tanaka, Hiroshi Yukitake, Yves Dauvilliers, Emmanuel Mignot   +13 more
openalex   +1 more source

Sleep and Rhythmic Profile After Pineal Gland Removal in Humans

Journal of Sleep Research, EarlyView.
ABSTRACT Melatonin, a hormone produced by the pineal gland, is classically described as a central circadian modulator. However, the impact of its absence on circadian rhythmicity in humans remains poorly understood. Pinealectomised patients, in whom melatonin secretion is chronically suppressed, represent a valuable clinical model to investigate the ...
Renata de Andrade Prado Gobetti, Clarissa Bueno, Letícia M. S. F. A. Soster, Anna Carolina de Campos de Barros Luvizotto Monazzi, Fernanda Gaspar do Amaral, Andréa Maria Capellano, Nasjla Saba da Silva, José Cipolla‐Neto   +7 more
wiley   +1 more source

Healthcare Burden and Productivity Loss Due to Narcolepsy in Sweden

Clocks & Sleep
Background: Narcolepsy impacts both patients and society, yet there is limited data on its socioeconomic consequences. Methods: This retrospective longitudinal cohort study used pseudonymized patient-level data from Swedish registers and included ...
Anna Giertz, Johan Mesterton, Tanja Jakobsson, Stephen Crawford, Somraj Ghosh, Anne-Marie Landtblom   +5 more
doaj   +1 more source

Once‐Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy

Journal of Sleep Research, EarlyView.
ABSTRACT Data from the REST‐ON trial were not available before the 2021 American Academy of Sleep Medicine (AASM) clinical practice guideline update, which included a literature review through August 2020. This post hoc analysis from REST‐ON assessed participants who achieved clinically significant improvements on individual AASM clinical significance ...
Luis E. Ortiz, Anne Marie Morse, Michael J. Thorpy, Clete A. Kushida, John Harsh, Thomas Roth, Jennifer Gudeman, Yves Dauvilliers   +7 more
wiley   +1 more source

Narcolepsy: A Chronic Neurological Disorder - A Review

, 2021
Aanchal Ajit Jain
openalex   +1 more source