Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic
Molecules, 2021 Antipruritic effects of kappa opioid receptor (KOR) agonists have been shown in rodent models of acute and chronic scratching (itchlike behavior). Three KOR agonists, nalfurafine, difelikefalin, and nalbuphine, are in clinical studies for antipruritic ...
Saadet Inan, Nae J. Dun, Alan Cowan
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Pharmaceutics, 2022 Pentazocine (PTZ), a narcotic-antagonist analgesic, has been extensively used in the treatment of initial carcinogenic or postoperative pain. Hepatic first-pass metabolism results in low oral bioavailability and high dose wastage.
Zaheer Ullah Khan +10 more
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Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. [PDF]
PLoS ONE, 2013 Novel classes of pain-relieving molecules are needed to fill the void between non-steroidal anti-inflammatory agents and narcotics. We have recently shown that intraplantar administration of sphingosine 1-phosphate (S1P) in rats causes peripheral ...
Amanda Finley +5 more
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Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
Journal of Pharmacological Sciences, 2007 In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki +5 more
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Biodegradable polymeric prodrugs of naltrexone [PDF]
, 1991 The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the ¿-amino acids N5-(3-hydroxypropyl--glutamine
Adams, N.W. +5 more
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Indian Journal of Urology, 2014 The objective of this review article is to present the current literature on medical expulsive therapy (MET) and help guide practitioners in the appropriate use of MET for treatment of stone disease.
Kyle D Wood +2 more
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Flexor Reflex Decreases during Sympathetic Stimulation in Chronic Human Spinal Cord Injury [PDF]
, 2009 A better understanding of autonomic influence on motor reflex pathways in spinal cord injury is important to the clinical management of autonomic dysreflexia and spasticity in spinal cord injured patients.
Garrison, Mark Kevin, Schmit, Brian D.
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Single high-dose buprenorphine for opioid craving during withdrawal. [PDF]
, 2018 BackgroundOpioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a ...
Ahmadi, Jamshid +3 more
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The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]
, 1964 1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
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Potentially inappropriate prescribing in nursing home residents detected with the community pharmacist specific GheOP3S-tool [PDF]
, 2016 Background: The Ghent Older People’s Prescriptions community Pharmacy Screening (GheOP3S-)tool was recently developed to screen for potentially inappropriate prescribing (PIP).
Boussery, Koen +7 more
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