Sex-specific recombination rates and allele frequencies affect the invasion of sexually antagonistic variation on autosomes [PDF]
Journal of Evolutionary Biology 26 (2013) 2428, 2013 The introduction and persistence of novel sexually antagonistic alleles can depend upon factors that differ between males and females. Understanding the conditions for invasion in a two-locus model can elucidate these processes. For instance, selection can act differently upon the sexes, or sex-linkage can facilitate the invasion of genetic variation ...
arxiv +1 more source
Emotional Contagion-Aware Deep Reinforcement Learning for Antagonistic Crowd Simulation [PDF]
arXiv, 2021 The antagonistic behavior in the crowd usually exacerbates the seriousness of the situation in sudden riots, where the antagonistic emotional contagion and behavioral decision making play very important roles. However, the complex mechanism of antagonistic emotion influencing decision making, especially in the environment of sudden confrontation, has ...
arxiv
The Efficacy of Peripheral Opioid Antagonists in Opioid-Induced Constipation and Postoperative Ileus: A Systematic Review of the Literature. [PDF]
, 2017 Opioid-induced constipation has a negative impact on quality of life for patients with chronic pain and can affect more than a third of patients. A related but separate entity is postoperative ileus, which is an abnormal pattern of gastrointestinal ...
Baratta, Jaime L. +5 more
core +1 more source
Extreme antagonism arising from gene-environment interactions [PDF]
, 2020 Antagonistic interactions in biological systems, which occur when one perturbation blunts the effect of another, are typically interpreted as evidence that the two perturbations impact the same cellular pathway or function. Yet, this interpretation ignores extreme antagonistic interactions wherein an otherwise deleterious perturbation compensates for ...
arxiv +1 more source
Amniotic-Fluid Ingestion Enhances the Central\ud Analgesic Effect of Morphine [PDF]
, 1991 Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin ...
DiPirro, Jean M. +2 more
core
Flexor Reflex Decreases during Sympathetic Stimulation in Chronic Human Spinal Cord Injury [PDF]
, 2009 A better understanding of autonomic influence on motor reflex pathways in spinal cord injury is important to the clinical management of autonomic dysreflexia and spasticity in spinal cord injured patients.
Garrison, Mark Kevin, Schmit, Brian D.
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund +5 more
wiley +1 more source
A Double‐Blind Comparison of Orally Administered Ciramadol and Codeine for Relief of Postoperative Pain [PDF]
, 1985 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97154/1/j.1552-4604.1985.tb02882.x ...
Bloomfield +13 more
core +1 more source
Environmental life cycle of fentanyl: From the cradle to an unknown grave
Journal of Environmental Quality, EarlyView.Abstract The lack of available information on the presence and persistence of fentanyl in the environment is a significant gap in the technical literature. Although the origins of the opioid in the environment are well‐known because they follow the same pathways of other drug‐related environmental contaminants, the downstream effects of fentanyl in the
Deseree J. Reid +5 more
wiley +1 more source
Transdemal Delivery of Opioid Antagonist Prodrugs [PDF]
, 2003 A composition, a method and an apparatus for transdermally delivering an effective amount of opioid antagonists derived from prodrugs for treatment of eating disorders, narcotic dependence and alcoholism.
Stinchcomb, Audra L., Swaan, Peter W.
core +1 more source