Results 61 to 70 of about 557,947 (269)

Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures [PDF]

open access: yes, 2019
There can be a fine line between therapeutic intervention and substance abuse, and this point is clearly exemplified in herbal cannabis and its products.
Dallas, Mark L.   +6 more
core   +3 more sources

Painful Realities: Navigating the Complexities of Head and Neck Cancer Pain

open access: yesOral Diseases, EarlyView.
ABSTRACT Background Head and neck cancer (HNC) and its treatments can cause significant pain, which can profoundly impact patients' quality of life and treatment outcomes. Understanding the full scope of HNC pain is essential for effective management and improved patient care.
Hayden F. Byrd, Zachary A. Kohutek
wiley   +1 more source

Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release [PDF]

open access: yes, 2013
We report the biological evaluation of a class of adamantane derivatives, which were achieved via modified telescoped machine-assisted flow procedure.
Battilocchio   +12 more
core   +1 more source

Scenes From a Sociolegal Career: An Informal Memoir

open access: yesRegulation &Governance, EarlyView.
ABSTRACT This memoir describes the 40‐year unfolding, project by project, of my sociolegal field research on legal and regulatory processes. It provides brief accounts of my interactions and interviews with regulatory officials and with businesspeople responsible for regulatory compliance.
Robert A. Kagan
wiley   +1 more source

Interaction of the Opiate and Neuroendocrine Systems [PDF]

open access: yes, 2011
Opiates are known to produce various physiological effects. Our understanding of these effects has been greatly increased by the discovery of the opiate receptor and the endogenous opioid peptides.
DeMaria, Jr, MD, Peter
core   +1 more source

Physiology of nitrogen: A life or death matter

open access: yesExperimental Physiology, EarlyView.
Abstract With each breath, four out of every five molecules we inspire are nitrogen (N2), since this gas constitutes ∼80% of the atmospheric air that surrounds us. Despite its abundance and unlike molecular oxygen, N2 has traditionally held less appeal among physiologists given its lack of reactivity and corresponding inability to support combustion or
Damian M. Bailey   +2 more
wiley   +1 more source

Healthcare Practitioner and Other Professionals' Perspectives on Gabapentinoid Misuse and Dependence: A Systematic Review of Qualitative Studies

open access: yesEuropean Journal of Pain, Volume 29, Issue 9, October 2025.
ABSTRACT Background and Objective The global rise in gabapentinoid prescriptions for chronic pain has been striking. However, this trend has been accompanied by growing concerns about misuse and dependence. This qualitative systematic review aimed to synthesise the perspectives of healthcare practitioners and other professionals on these emerging ...
Amy G. McNeilage   +4 more
wiley   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

open access: yesBiological Reviews, Volume 100, Issue 5, Page 1994-2019, October 2025.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett   +4 more
wiley   +1 more source

Effects of reducing sedentary behaviour on renal glucose uptake during insulin stimulation: A post‐hoc analysis of a 6‐month randomized controlled trial

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5772-5781, October 2025.
Abstract Aims Obesity is an independent risk factor for chronic kidney disease, and weight loss interventions lead to better kidney outcomes. We aimed to assess whether reducing sedentary behaviour in patients with metabolic syndrome impacts renal glucose uptake rate (GU) during insulin stimulation.
Eleni Rebelos   +19 more
wiley   +1 more source

Home - About - Disclaimer - Privacy