Results 11 to 20 of about 23,788 (138)

Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases

Frontiers in Pharmacology, 2022
Cav1.2 plays an essential role in learning and memory, drug addiction, and neuronal development. Intracellular calcium homeostasis is disrupted in neurodegenerative diseases because of abnormal Cav1.2 channel activity and modification of downstream Ca2 ...
Yun Li, Hong Yang, Tianhan He, Liang Zhang, Chao Liu   +4 more
doaj   +1 more source

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Frontiers in Neuroscience, 2021
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle.
Weinan Zhao, Weinan Zhao, Weinan Zhao, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Yu Ma, Yu Ma, Yu Ma, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Bingqian Fan, Bingqian Fan, Bingqian Fan, Xiaojing Zhai, Xiaojing Zhai, Xiaojing Zhai, Mengfan Hu, Mengfan Hu, Mengfan Hu, Mengfan Hu, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Yixue Qin, Yixue Qin, Yixue Qin, Yixue Qin, Sha Sha, Sha Sha, Sha Sha, Sha Sha, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Fan Ye, Yihan Xia, Guangchao Zhang, Guangchao Zhang, Guangchao Zhang, Li Yang, Li Yang, Li Yang, Shiya Zou, Shiya Zou, Shiya Zou, Zheng Xu, Zheng Xu, Zheng Xu, Sunhui Xia, Sunhui Xia, Sunhui Xia, Yumei Yu, Yumei Yu, Yumei Yu, Mannan Abdul, Mannan Abdul, Mannan Abdul, Mannan Abdul, Jun-Xia Yang, Jun-Xia Yang, Jun-Xia Yang, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Fang Zhou, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang   +83 more
doaj   +1 more source

The PrLGlu→avBNSTGABA circuit rapidly modulates depression-like behaviors in male mice

iScience, 2023
Summary: Depression is a global disease with a high prevalence. Here, we examine the role of the circuit from prelimbic mPFC (PrL) to the anterior ventral bed nucleus of the stria terminalis (avBNST) in depression-like mice through behavioral tests ...
Jie-ying Chen, Ke Wu, Miao-miao Guo, Wei Song, Si-ting Huang, Yong-mei Zhang   +5 more
doaj   +1 more source

Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

Neurobiology of Stress, 2022
Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang   +6 more
doaj   +1 more source

Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice

Frontiers in Aging Neuroscience, 2022
Recent observation demonstrated that prolonged anesthesia modifies brain synaptic architecture in all ages, including adult. Propofol is the most commonly utilized anesthetics at clinic.
Xiaoxuan Yang, Chen Chen, Chen Chen, Dongmei Qu, Yanping Liu, Yanping Liu, Ning Wang, Ning Wang, Haibi Wang, Haibi Wang, Youjia Fan, Yushan Zhou, Buwei Yu, Qingsheng Xue, Yuqing Wu, Yuqing Wu, Han Lu   +16 more
doaj   +1 more source

Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp technique

STAR Protocols, 2023
Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji, Xiang-Ying Xu, Cui Yin, Chunyi Zhou, Cheng Xiao   +4 more
doaj   +1 more source

Adjudication and Treatment of Narcotic Drug Offenders in Ghana

The Journal of Medicine, Law & Public Health, 2023
Narcotic drug trafficking is a criminal and punishable offence in every country the world over. The use of certain narcotic drugs, on the other hand (especially marijuana), has been legalised in some countries, but under strict regulations.
Jacob Agboli
doaj   +1 more source

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

Cell Death and Disease
Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral
Wei Song, Zi-ming Zhou, Le-le Zhang, Hai-feng Shu, Jin-ru Xia, Xia Qin, Rong Hua, Yong-mei Zhang   +7 more
doaj   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction

Cellular & Molecular Biology Letters
Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu, Chen Chen, Jia-Tao Lin, Xin-Hao Jiao, Wei Dong, Jie Wan, Qiang Liu, Yong-Kang Qiu, Ao Sun, Yi-Qi Liu, Chun-Hui Jin, He Huang, Hui Zheng, Cheng-Hua Zhou, Yu-Qing Wu   +14 more
doaj   +1 more source