Results 11 to 20 of about 54,328 (276)
The Role of Epigenetic Modifications in Neurotoxicity Induced by Neonatal General Anesthesia
Frontiers in Molecular Neuroscience, 2022 It has been widely demonstrated by numerous preclinical studies and clinical trials that the neonates receiving repeated or long-time general anesthesia (GA) could develop prolonged cognitive dysfunction.
Lin-Hui Ma +8 more
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Chinese Medicine, 2023 Background The clinical applications of dispensing granules (DG) have increased dramatically. However, it is controversial whether the DG has the same quality and efficacy compared with traditional decoction (TD).
Huanhuan Yu +7 more
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All opinions are not equal: Toward a consensual approach to the development of drug policy
Australian Journal of Social Issues, Volume 57, Issue 4, Page 812-828, December 2022., 2022 Abstract Drug policy has been subjected to much scrutiny from different stakeholder groups who present sometimes very different opinions on solutions to address a problem. Reconciling such differences, that are underpinned by both anecdotal and empirical evidence, is a priority yet to be fully achieved.
Gabriel T. W. Wong, Matthew Manning
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Cell Death Discovery, 2021 Alzheimer’s disease (AD) is characterized by aberrant accumulation of extracellular β-amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most neurotoxic species and are correlated with cognitive dysfunction in early AD ...
Xiu Yang +13 more
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J‐SUPPORT research policy for oral mucositis associated with cancer treatment
Cancer Medicine, Volume 11, Issue 24, Page 4816-4829, December 2022., 2022 Abstract Background Oral mucositis is one of the main areas of research in supportive and palliative care of cancer patients. However, the methodology of prospective clinical trials on oral mucositis has not been established, despite its uniqueness.
Tomoya Yokota +7 more
wiley +1 more source
Frontiers in Psychiatry, 2022 ObjectiveThis study aimed to explore transcranial electrical stimulation (tES) to relieve peripartum anxiety and depressive symptoms in women undergoing cesarean section with combined spinal–epidural anesthesia.MethodsThis double-blind, randomized, sham ...
Qiu Zhao +30 more
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A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep
Nature Communications, 2023 A comorbidity of chronic pain is sleep disturbance. Here, we identify a dual-functional ensemble that regulates both pain-like behaviour induced by chronic constrictive injury or complete Freund’s adjuvant, and sleep wakefulness, in the nucleus accumbens
Haiyan Sun +8 more
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Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 423-434, February 2023., 2023 This study evaluated drug–drug interactions (DDIs) between antibiotic and nonantibiotic drugs listed with warnings of severe outcomes in the British National Formulary based on adverse drug reaction (ADR) detectable with routine International Classification of Diseases, Tenth Revision coding.
Tjeerd Pieter van Staa +4 more
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Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases
Frontiers in Pharmacology, 2022 Cav1.2 plays an essential role in learning and memory, drug addiction, and neuronal development. Intracellular calcium homeostasis is disrupted in neurodegenerative diseases because of abnormal Cav1.2 channel activity and modification of downstream Ca2 ...
Yun Li +4 more
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The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice
Frontiers in Molecular Neuroscience, 2022 The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but normal ...
Ye Liu +34 more
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