Results 11 to 20 of about 25,223 (258)

Transcranial Electrical Stimulation for Relief of Peripartum Mental Health Disorders in Women Undergoing Cesarean Section With Combined Spinal–Epidural Anesthesia: A Pilot Randomized Clinical Trial

open access: yesFrontiers in Psychiatry, 2022
ObjectiveThis study aimed to explore transcranial electrical stimulation (tES) to relieve peripartum anxiety and depressive symptoms in women undergoing cesarean section with combined spinal–epidural anesthesia.MethodsThis double-blind, randomized, sham ...
Qiu Zhao   +30 more
doaj   +1 more source

Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases

open access: yesFrontiers in Pharmacology, 2022
Cav1.2 plays an essential role in learning and memory, drug addiction, and neuronal development. Intracellular calcium homeostasis is disrupted in neurodegenerative diseases because of abnormal Cav1.2 channel activity and modification of downstream Ca2 ...
Yun Li   +4 more
doaj   +1 more source

The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice

open access: yesFrontiers in Molecular Neuroscience, 2022
The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but normal ...
Ye Liu   +34 more
doaj   +1 more source

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

open access: yesFrontiers in Neuroscience, 2021
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle.
Weinan Zhao   +83 more
doaj   +1 more source

Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice

open access: yesFrontiers in Aging Neuroscience, 2022
Recent observation demonstrated that prolonged anesthesia modifies brain synaptic architecture in all ages, including adult. Propofol is the most commonly utilized anesthetics at clinic.
Xiaoxuan Yang   +16 more
doaj   +1 more source

Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice

open access: yesCell Reports, 2023
Summary: The neural circuit mechanisms underlying postoperative cognitive dysfunction (POCD) remain elusive. We hypothesized that projections from the medial prefrontal cortex (mPFC) to the amygdala are involved in POCD.
Xiao-Yu Sun   +7 more
doaj  

Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

open access: yesActa Pharmaceutica Sinica B, 2023
Colorectal cancer (CRC) is a type of malignant tumor that seriously threatens human health and life, and its treatment has always been a difficulty and hotspot in research.
Haowei Liu   +5 more
doaj  

The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice

open access: yesFrontiers in Pharmacology, 2023
Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state.
Jing Liu   +31 more
doaj   +1 more source

Adjudication and Treatment of Narcotic Drug Offenders in Ghana

open access: yesThe Journal of Medicine, Law & Public Health, 2023
Narcotic drug trafficking is a criminal and punishable offence in every country the world over. The use of certain narcotic drugs, on the other hand (especially marijuana), has been legalised in some countries, but under strict regulations.
Jacob Agboli
doaj   +1 more source

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

open access: yesCell Death and Disease
Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral
Wei Song   +7 more
doaj   +1 more source

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