Results 51 to 60 of about 25,223 (258)

Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors

Frontiers in Pharmacology
IntroductionThe paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A2A
Yiping Cao, Yiping Cao, Yiping Cao, Zhou Wu, Zhou Wu, Zhou Wu, Moruo Zhang, Moruo Zhang, Moruo Zhang, Ran Ji, Ran Ji, Ran Ji, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang, Lingzhen Song, Lingzhen Song, Lingzhen Song   +17 more
doaj   +1 more source

Commentary on Ezard et al.: Agonist-based medications for stimulant use disorder-Distinguishing their true colours. [PDF]

Addiction
Addiction, Volume 120, Issue 7, Page 1363-1365, July 2025.
Tardelli VS, Fidalgo TM.
europepmc   +2 more sources

Nanoarchitecturing of Bimetallic Metal‒Organic Frameworks for Emerging Applications in Quartz Crystal Microbalance Gas Sensors

Small Methods, EarlyView.
This review summarizes recent progress in the design and nanoarchitectural control of bimetallic metal–organic frameworks (MOFs) and their applications in quartz crystal microbalance (QCM) sensors for the detection of various gases. It also discusses the underlying sensing mechanisms of bimetallic MOFs and concludes with challenges and future ...
Silvia Chowdhury, Asep Sugih Nugraha, Brian Yuliarto, Yusuke Yamauchi, Yusuf Valentino Kaneti   +4 more
wiley   +1 more source

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel

Nature Communications
Lysosomes are best known for their roles in inflammatory responses by engaging in autophagy to remove inflammasomes. Here, we describe an unrecognized role for the lysosome, showing that it finely controls macrophage inflammatory function by manipulating
Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang   +18 more
doaj   +1 more source

Minimal Hepatic Encephalopathy in Cirrhotic Patients: A New Simple and Fast Digital Screening Method

United European Gastroenterology Journal, EarlyView.
ABSTRACT Backround Minimal hepatic encephalopathy is a common and prognostically severe complication of cirrhosis with a significant impact on the quality of life. Detailed diagnostic work‐up of minimal hepatic encephalopathy is time‐consuming and difficult to integrate into daily clinical routine.
Henrike Dobbermann, Raffael Schlüter, Yevgeniy Lyubchenko, Johanna Beder, Sven Danneberg, Katharina Mitzlaff, Iris Engelbart, Jakob Jessberger, Felix Braun, Thomas Becker, Christian Labenz, Monique Janneck, Denys Matthies, Friedhelm Sayk, Jens U. Marquardt   +14 more
wiley   +1 more source

Nonmedical cannabis legalization policy in Canada: Has commercialization been a pivotal mistake for public health?

World Medical &Health Policy, Volume 17, Issue 1, Page 167-175, March 2025.
Abstract Canada implemented the legalization of nonmedical cannabis use and supply in 2018. Initial blueprints for the legalization policy framework emphasized public health protection as a priority principle and objective, including related policy design parameters and regulatory restrictions (e.g., strict access and distribution control ...
Benedikt Fischer, Wayne Hall, Didier Jutras‐Aswad, Daniel Myran   +3 more
wiley   +1 more source

A Flight Back to Ground: Jung’s Recalcitrant Fourth as Rape into Consciousness. Symbolic Rape and Literal Rape in Persephone’s Myth

Journal of Analytical Psychology, EarlyView.
Abstract Patricia Berry’s interpretation of the Demeter/Persephone myth, and her concept of rape into consciousness, illuminate intrapsychic dynamics. However, this symbolic lens may inadvertently distance us from the devastating nature of literal rape—a reality the Homeric Hymn encapsulates.
Barbara Cerminara
wiley   +1 more source

FEATURES OF STORAGE AND TRANSPORTATION OF NARCOTIC ANALGESICS IN CONDITIONS OF EMERGENCY SITUATIONS

Фармация и фармакология (Пятигорск), 2015
The article performs the analysis of the current state regulatory-legal framework relating to the use of narcotic analgesics in health care institutions in emergencies peace and wartime.There are developed recommendations for adapting the requirements ...
P. V. Oliynyk, B. P. Hromovyk
doaj   +1 more source

The impacts of policies controlling the spatial availability of take‐away alcohol on consumption and harms: A systematic narrative review

Addiction, EarlyView.
Abstract Aim To systematically review the evidence on the impacts of policies regulating the spatial availability of off‐premises alcohol on consumption and harms. Methods Narrative review that examined peer‐reviewed studies published from 2016 to 2024 on policy changes affecting the spatial availability of off‐premises alcohol.
Shima Shakory, Brendan T. Smith, Rachel Jansen, Breanne Reel, Erin Hobin   +4 more
wiley   +1 more source

MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated mitochondrial biogenesis

Acta Biochimica et Biophysica Sinica
Bone cancer pain (BCP), due to cancer bone metastasis and bone destruction, is a common symptom of tumors, including breast, prostate, and lung tumors. Patients often experience severe pain without effective treatment.
Yang Long, Li Miaomiao, Liu Yucheng, Bai Yang, Yin Tianyu, Chen Yangyang, Jiang Jinhong, Liu Su   +7 more
doaj   +1 more source