Results 51 to 60 of about 23,788 (138)

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel

Nature Communications
Lysosomes are best known for their roles in inflammatory responses by engaging in autophagy to remove inflammasomes. Here, we describe an unrecognized role for the lysosome, showing that it finely controls macrophage inflammatory function by manipulating
Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang   +18 more
doaj   +1 more source

Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors

Frontiers in Pharmacology
IntroductionThe paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A2A
Yiping Cao, Yiping Cao, Yiping Cao, Zhou Wu, Zhou Wu, Zhou Wu, Moruo Zhang, Moruo Zhang, Moruo Zhang, Ran Ji, Ran Ji, Ran Ji, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang, Lingzhen Song, Lingzhen Song, Lingzhen Song   +17 more
doaj   +1 more source

DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

iScience
Summary: Experimental studies have shown that neuropathic pain impairs hippocampal synaptic plasticity. Here, we sought to determine the underlying mechanisms responsible for synaptic changes in neuropathic painful mouse hippocampal neurons.
Li Yang, Qiaoqiao Liu, Yaxuan Zhao, Ninghua Lin, Yue Huang, Qihui Wang, Kehui Yang, Runa Wei, Xiaotong Li, Ming Zhang, Lingyun Hao, Hongjun Wang, Zhiqiang Pan   +12 more
doaj   +1 more source

Paracetamol in Pregnancy: Reassurance Amidst Uncertainty

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
Athina Samara, Asma Khalil
wiley   +1 more source

Forensic classification of narcotic drugs

Bulletin of Kharkiv National University of Internal Affairs
The development of means and methods for preventing and combating drug-related crime depends on an understanding of trends in the illicit drug market. This requires the use of a forensic classification of the relevant substances.
R. L. Stepaniuk, S. M. Lozova
doaj   +1 more source

MANAGEMENT ASPECT OF THE PROBLEM OF NARCOTIC DRUGS USE

Фармакоэкономика, 2016
The use of narcotic drugs in healthcare system nowadays is characterized by lawful aspects prevalence over medical, bioethics, economic and social aspects.
S. Yu. Soboleva, A. V. Sobolev, I. A. Kaminskaya   +2 more
doaj   +1 more source

AN OVERVIEW OF THE NEW REGULATIONS ON CIRCULATION OF NARCOTIC DRUGS, PSYCHOTROPIC SUBSTANCES AND THEIR PRECURSORS

Медицинский вестник Юга России, 2016
Presents an overview of regulations on circulation of narcotic and psychotropic substances, which entered into force in 2015. The analysis of each instrument and particularly deployed, explained the fundamental differences from previous editions.
T. A. Polinskaya, E. S. Berezhnaya, J. S. Efimova   +2 more
doaj   +1 more source

OPINIONS OF SENIOR SCHOOLCHILDREN ON DRUGS IN THE INTERNET: RESULTS OF A PILOT RESEARCH

Russian Journal of Economics and Law, 2017
Objective: to identify the level of engagement of schoolchildren in the process of distribution of narcotic drugs, psychotropic substances or their analogues via information and telecommunication networks of common use.Methods: the dialectical approach ...
A. A. Glukhova, A. A. Iudin, D. A. Shpilev   +2 more
doaj   +1 more source

Medical Use, Decriminalization, and Legalization of Narcotic Drugs and Psychotropic Substances-What Does It Mean and What Is Its Current Status in India? [PDF]

Indian J Psychol Med, 2023
Balhara YPS, Sarkar S, Singh S.
europepmc   +1 more source

Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark. [PDF]

Basic Clin Pharmacol Toxicol, 2023
Andersen CU, Ahmed H, Raedkjaer M, Hasselstrøm JB, Larsen MK.   +4 more
europepmc   +1 more source