Results 51 to 60 of about 3,781,173 (328)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease

Acta Neuropathologica Communications
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder among the elderly, with limited effective treatments available in clinical practice.
Miao-Jin Ji, Yun Li, Jiao Yang, Kangjunjie Wang, Shuning Sang, Hong Yang, Chenhao Tian, Xin Tang, Ji-Heng Cai, Tianhan He, Cheng Zhang, Huanyao Tang, Tiantao Cui, Xinran Meng, Xiang Cao, Jiaqi Zhu, Jie Wang, Jun-Li Cao, Daming Gao, Chao Liu   +19 more
doaj   +1 more source

Cell types and neuronal genetic architecture in the rat CSF-contacting nucleus and the role of 5-HT in this nucleus in mediating morphine addiction through the brain–CSF circuit

Frontiers in Neuroscience
IntroductionTo elucidate the cellular composition of the cerebrospinal fluid-contacting nucleus, establish a comprehensive gene expression database for this nucleus, and investigate its potential functional roles.Methodswe used single-cell sequencing ...
Ying Li, Ying Li, Ying Li, Bin Gui, Bin Gui, Bin Gui, Yijun Zhang, Yijun Zhang, Yijun Zhang, Licai Zhang, Licai Zhang, Licai Zhang   +11 more
doaj   +1 more source

Immediate postoperative anesthesia with either lidocaine or bupivacaine: A short‐term clinical response

Journal of Periodontology, EarlyView.
Abstract Background The purpose of this randomized, three‐armed clinical trial is to determine if a postoperative injection of 0.5% bupivacaine is more effective than 2% lidocaine in controlling pain after periodontal flap surgery. Methods Seventy‐six patients planned for similar periodontal surgeries were included.
Jessica D. Koster, David E. Deas, Archontia Palaiologou, David J. Lasho, Anibal Diogenes   +4 more
wiley   +1 more source

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

eLife
Memory impairment in chronic pain patients is substantial and common, and few therapeutic strategies are available. Chronic pain-related memory impairment has susceptible and unsusceptible features.
Mengqiao Cui, Xiaoyuan Pan, Zhijie Fan, Shulin Wu, Ran Ji, Xianlei Wang, Xiangxi Kong, Zhou Wu, Lingzhen Song, Weiyi Song, Jun-Xia Yang, Hongjie Zhang, Hongxing Zhang, Hai-Lei Ding, Jun-Li Cao   +14 more
doaj   +1 more source

Reimagining Urban River Bathing in Europe: A Multisectoral and Interdisciplinary Dive Into Lyon's Rivers (France)

River Research and Applications, EarlyView.
ABSTRACT Urban river bathing is re‐emerging across Europe, driven by social demand and climate change impacts. The Urban Bathing Consortium, an interdisciplinary and intersectoral consortium initiated at the University of Lyon (France), is at the forefront of studying the challenges and opportunities of creating and managing healthy, safe, and ...
Yixin Cao, Patrice Barbiero, François Briat, Benoit Camenen, Frédéric Chambat, Victoria Chiu, Benoit Cournoyer, Magali Delavenne, Benjamin Dewals, Marie Epain, Anne Honegger, Jérôme Le Coz, Gislain Lipeme Kouyi, Célia Maghakian, Oldrich Navratil, Olivier Pillonel, Marion Porcherie, Sara Puijalon, Nicolas Riviere, Marie‐Florence Thomas, Richard Trillat, Laurence Volatier, Jean‐Marie Zanot   +22 more
wiley   +1 more source

Challenges of Effective Wildlife Law Enforcement in Oyo and Lagos States, Nigeria 尼日利亚奥约州与拉各斯州野生动物执法有效实施所面临的挑战

Wildlife Letters, EarlyView.
Effective wildlife law enforcement is important in the drive for biodiversity conservation. This study examined the challenges of wildlife law enforcement in Oyo and Lagos States of Nigeria across four security outfits (Nigerian Police Force [NPF], Nigerian Customs Service [NCS], National Environmental Standards and Regulations Enforcement Agency ...
Oluwatosin Mercy Dada, Omolola Oluwakemi Ajayi, Oluwakayode Michael Coker   +2 more
wiley   +1 more source

NAT10 inhibition alleviates astrocyte autophagy by impeding ac4C acetylation of Timp1 mRNA in ischemic stroke

Acta Pharmaceutica Sinica B
Although a single nucleotide polymorphism for N-acetyltransferase 10 (NAT10) has been identified in patients with early-onset stroke, the role of NAT10 in ischemic injury and the related underlying mechanisms remains elusive.
Li Yang, Xiaotong Li, Yaxuan Zhao, Hao Chen, Can Wang, Angrong Wu, Xintong Guo, Yue Huang, Qihui Wang, Lingyun Hao, Xiaowen Li, Ying Ji, Jin Ban, Guangtian Wang, Junli Cao, Zhiqiang Pan   +15 more
doaj   +1 more source

Ghosting at the border: the racialization of extraterritoriality at the US Supreme Court Les limbes de la frontière : racialisation de l'extraterritorialité par la Cour suprême des États‐Unis

Journal of the Royal Anthropological Institute, EarlyView.
The theoretical association of an inclusive public sphere with liberal democratic governing begs a closer examination. This article pursues forms of disqualification implicit in the idea of political community as a national project, ultimately finding that the exclusion of foreigners does not begin on the far side of the US border, but well within it ...
Carol J. Greenhouse
wiley   +1 more source

Drug‐facilitated crime: A review of findings between 2019 and 2023

Journal of Forensic Sciences, EarlyView.
Abstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Meaghan R. Hessler, Sherri L. Kacinko, Barry K. Logan   +2 more
wiley   +1 more source