Results 101 to 110 of about 262,065 (292)

Buspirone Nanovesicular Nasal System for Non-Hormonal Hot Flushes Treatment

Pharmaceutics, 2018
The aim of this work was to design and characterize a new nanovesicular nasal delivery system (NDS) containing buspirone, and investigate its efficiency in an animal model for the treatment of hot flushes.
Elka Touitou, Hiba Natsheh, Shaher Duchi
doaj   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. [PDF]

, 2009
The innate immune response of airway epithelial cells to airborne allergens initiates the development of T cell responses that are central to allergic inflammation.
Angkasekwinai, Pornpimon, Barranco, Wade T, Corry, David B, Dong, Chen, Goswami, Sangeeta, Greenlee, Kendra J, Kheradmand, Farrah, Polikepahad, Sumanth, Redding, David, Seryshev, Alexander, Shan, Ming, Singh, Bhupinder, Song, Li-zhen, Sur, Sanjiv, Woodruff, Prescott   +14 more
core  

2D Copper MOF Membranes with Precise Pores for Ionic Memory

Advanced Science, EarlyView.
 . ABSTRACT Biological ion channels play a critical role in the complex physiological processes of living organisms. Inspired by these natural systems, we demonstrate the fabrication of ultrathin 2D copper‐based metal‐organic framework (CuMOF) films and their application to mimic key functionalities of biological membranes. Using a liquid–air interface
Hiran Jyothilal, Raj Kumar Gogoi, Yuchen Liu, Vikas Sharma, Solleti Goutham, Michael Hutton, Rachel C. Kilbride, Daniel T.W. Toolan, Ashok Keerthi, Boya Radha   +9 more
wiley   +1 more source

Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice

Allergology International, 2009
Background: Peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosinophils.
Naoko Fukui, Kohei Honda, Eiko Ito, Kazuo Ishikawa   +3 more
doaj   +1 more source

DFN-02, Sumatriptan 10 mg Nasal Spray with Permeation Enhancer, for the Acute Treatment of Migraine: A Randomized, Double-Blind, Placebo-Controlled Study Assessing Functional Disability and Subject Satisfaction with Treatment. [PDF]

, 2019
BackgroundThe commercial formulation of sumatriptan nasal spray is an effective option for migraine patients requiring or preferring a non-oral route of drug administration, but its utility is limited by poor absorption and tolerability issues. DFN-02, a
Brand-Schieber, Elimor, Lipton, Richard B, Munjal, Sagar, Rapoport, Alan M   +3 more
core  

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Fracture Nasal Bones [PDF]

, 2013
Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face.  Although fractures involving the nasal bones are very common, it is often ignored by the patient.
Thiagarajan, Balasubramanian, Ulaganathan, Venkatesan   +1 more
core   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source