Results 31 to 40 of about 2,438,339 (329)

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

Epilepsy & Behavior Reports, 2023
Nasal administration of treatments for neurologic conditions, including rescue therapies to treat seizure clusters among people with epilepsy, represents a meaningful advance in patient care.
Steve Chung, Jurriaan M. Peters, Kamil Detyniecki, William Tatum, Adrian L. Rabinowicz, Enrique Carrazana   +5 more
doaj   +1 more source

A patient preference study that evaluated fluticasone furoate and mometasone furoate nasal sprays for allergic rhinitis [PDF]

, 2016
Background: Corticosteroid nasal sprays are the mainstay of treatment for allergic rhinitis. These sprays have sensory attributes such as scent and/or odor, taste and aftertaste, and run down the throat and/or the nose, which, when unpleasant, can affect
Bremner, P, Dimitroff, A, Johnson, N, Luscombe, G, Prillaman, B, Rhee, C, Yanez, A   +6 more
core   +2 more sources

Current prospects and future challenges for nasal vaccine delivery [PDF]

, 2016
Nasal delivery offers many benefits over traditional approaches to vaccine administration. These include ease of administration without needles that reduces issues associated with needlestick injuries and disposal.
Kett, Vicky, Yusuf, Helmy
core   +2 more sources

Protective Effect of Insulin in Mouse Nasal Mucus Against Olfactory Epithelium Injury

Frontiers in Neural Circuits, 2021
Insulin is present in nasal mucus and plays an important role in the survival and activity of individual olfactory sensory neurons (OSNs) via insulin receptor-mediated signaling.
Shu Kikuta, Akihito Kuboki, Tatsuya Yamasoba   +2 more
doaj   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

Dissociative Effects of Neuropeptide S Receptor Deficiency and Nasal Neuropeptide S Administration on T-Maze Discrimination and Reversal Learning

Pharmaceuticals, 2021
Cognitive flexibility refers to the ability to modify learned behavior in response to changes in the environment. In laboratory rodents, cognitive flexibility can be assessed in reversal learning, i.e., the change of contingencies, for example in T-maze ...
Ahmet Oguzhan Bicakci, Pei-Ling Tsai, Evelyn Kahl, Dana Mayer, Markus Fendt   +4 more
doaj   +1 more source

The nasal delivery of nanoencapsulated statins – An approach for brain delivery [PDF]

, 2016
© 2016 Clementino et al. Purpose: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases.
Barboza, T, Batger, M, Cantù, L, Clementino, A, Del Favero, E, Garrastazu, G, Gutfilen, B, Pozzoli, M, Rondelli, V, Sonvico, F, Souza, SAL, Sukkar, MB   +11 more
core   +2 more sources

Acute toxicity of the intranasal administration of Anredera cordifolia extract in Wistar Rats [PDF]

Pharmaciana
Anredera cordifolia (AC) known as the binahong plant in Indonesia has been commonly used for traditional medicine since the ancients. AC contains secondary metabolites such as flavonoids that have anti-oxidative, anti-inflammatory, anti-mutagenic, and ...
Asti Widuri, Rifki Febriansah
doaj   +1 more source

Mucoadhesive, Thermoreversible Hydrogel, Containing Tetracaine-Loaded Nanostructured Lipid Carriers for Topical, Intranasal Needle-Free Anesthesia

Pharmaceutics, 2021
Recent advances have been reported for needle-free local anesthesia in maxillary teeth by administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain, fear, and stress.
Giovana Maria Fioramonti Calixto, Bruno Vilela Muniz, Simone R. Castro, Jaiza Samara Macena de Araujo, Klinger de Souza Amorim, Lígia N. M. Ribeiro, Luiz Eduardo Nunes Ferreira, Daniele Ribeiro de Araújo, Eneida de Paula, Michelle Franz-Montan   +9 more
doaj   +1 more source

Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures. [PDF]

, 2001
OBJECTIVE: To compare the effectiveness of nasal diamorphine spray with intramuscular morphine for analgesia in children and teenagers with acute pain due to a clinical fracture, and to describe the safety profile of the spray.
Kendall, JM, Latter, VS, Nasal Diamorphine Trial Group, Reeves, BC   +3 more
core   +1 more source